Seroprevalence of HHV 8 antibodies among the general population and HIV positive persons in the Czech Republic

Comparison of Prevalence of Kaposi's Sarcoma in HHV8+ and HHV8- HIV Infected Patients in South-South Nigeria

“…Studies have shown that lytic viral replication of HHV-8 predispose to development of Kaposi's sarcoma (KS) and among HIV infected patients lytic HHV-8 replication may also promote HIV disease progression (Engels EA, 2003;Caselli E, 2005;Suchankova A, 2003). Reports from Brazil and Cuba (Kouri V, 2004) showed that HHV-8 seroprevalence in patients with AIDS-associated Kaposi's sarcoma to be 79.5% and 77.8% respectively (Keller R, 2001;Kouri V, 2004).…”

Acquired Haemophilia A and Kaposi’s Sarcoma in an HIV-Negative, HHV-8-Positive Patient: A Discussion of Mechanism and Aetiology

“…It is a gammaherpesvirus able to persist within the lymphoid system. Furthermore, it is not a ubiquitous virus, as it has been shown to only infect a few percent of the population [5]. In latent cycle replication, the virus infects mainly B cells [6], though recently it has been shown to also infect macrophages, natural killer cells and, to a lesser extent, dendritic cells in immunodeficient mice [7].…”

“…In latent cycle replication, the virus infects mainly B cells [6], though recently it has been shown to also infect macrophages, natural killer cells and, to a lesser extent, dendritic cells in immunodeficient mice [7]. Primary infection with HHV-8 does not generally present with a specific primary infection syndrome [5], even though reports on febrile illness with maculopapular rash have been published [8,9]. KS was first described as a rare disease among elderly Mediterranean men and later on among African children [10].…”

“…The virus is associated with several lymphoproliferative disorders – KS, multicentric Castleman’s disease and primary effusion lymphoma. Altered host control of viral production via (iatrogenic or acquired) immunosuppression is generally needed in order for a lymphoproliferative disorder to occur [5]. …”

Human herpesvirus 8 enhances human immunodeficiency virus replication in acutely infected cells and induces reactivation in latently infected cells

“…[10][11][12] The incidence of HHV-8 infection varies among different geographic areas, [13][14][15] with higher values of prevalence in areas where HIV infection is widespread 16,17 or in patients infected with HIV from areas where the virus is rarely detected in the healthy population. 13,14,[18][19][20] HHV-8 establishes latent infections in the healthy population, with high prevalence in sub-Saharan Africa, intermediate prevalence in the Mediterranean area, and very low prevalence in North Europe and North America. 21 Also in KS and PELs most neoplastic cells support a latent HHV-8 infection.…”