Seroprevalence of hepatitis B among pregnant women in Kigali, Rwanda

Nyamusi, Mochama Monica; Marete, Onesmus; Waweru, Wilson R.

doi:10.18203/2394-6040.ijcmph20163918

Cited by 7 publications

(6 citation statements)

References 11 publications

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“…The demographic characteristics of the study population are similar to other populations as per the studies in Kigali, Lacor, and Gulu and in Tanzania [8,16,22]. There was no statistically significant association between the socio-demographic characteristics and hepatitis B surface antigen positivity in this study (Table 4).…”

Section: Factors Associated With Hepatitis B Surface Antigen Positivitysupporting

confidence: 78%

Prevalence and Factors Associated with Hepatitis B Surface Antigen Positivity among Women Receiving Antenatal Care at Mbarara Regional Referral Hospital

Aheisibwe¹,

Mugisha²,

Ngonzi³

et al. 2019

J Trop Dis

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Background: Hepatitis B infection is a disease of public health significance. The burden of the disease among the pregnant women at Mbarara Regional Referral Hospital was not known yet determining seropositivity at antenatal care could prevent HBV in the newborn. This study assessed the prevalence and factors associated with hepatitis B surface antigen positivity among women attending antenatal care at Mbarara Regional Referral Hospital. Methods: This was a cross-sectional study that consisted of 385 pregnant women who attended antenatal care clinic at Mbarara Regional Referral Hospital in a period of three months beginning December 2018 to February 2018. Blood samples were tested for HBsAg using immune-chromatography and positive samples confirmed using the ARCHITECT S2000r system. Data was collected using a structured questionnaire. Logistic regression analysis to assess associated factors with HBsAg was done, results were presented in tables. Results: Three hundred eighty-five women were enrolled in the study. Their median age was 26 years. Prevalence of current (HBsAg) was 3.12% (95% CI 1.62-5.38%). Prevalence of HBsAg was higher. The factors associated with HBsAg positivity were having more than one sexual partner 10.3% or 4.695% CI (1.34-16.30) p-value=0.016, history of valval ulcerations 0. R=3.35(CI 1.04-10.77), p-value=0.045 and history of body piercing 12.88% (CI 1.34-124.40), p=0.0027. Conclusion: The prevalence of hepatitis B surface antigen positivity among pregnant women receiving antenatal care at Mbarara Regional Referral Hospital is high. According to the WHO classification of hepatitis B infection, results show intermediate endemicity, and this clearly points to the need for universal screening of all women attending antenatal care at Mbarara Hospital.

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Section: Factors Associated With Hepatitis B Surface Antigen Positivitysupporting

confidence: 78%

Prevalence and Factors Associated with Hepatitis B Surface Antigen Positivity among Women Receiving Antenatal Care at Mbarara Regional Referral Hospital

Aheisibwe¹,

Mugisha²,

Ngonzi³

et al. 2019

J Trop Dis

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“…Anaedobe, Fowotade [12] found a prevalence of 8.3% % among pregnant women in the south western part of Nigeria, and among pregnant women in Uganda, a prevalence of 11.8% was found [6]. Though, the prevalence in this study is lower than the aforementioned countries, it is higher than the prevalence in Rwanda (3.1%) [4], Ethiopia (4.7%) [7] and Tanzania (5.2%) [14]. The differences in findings across countries within the subregion might be due to geographical variations, differences in Table 3.…”

Section: Discussioncontrasting

confidence: 56%

“…HBV is the commonest hepatitis virus during pregnancy [2]. Evidence show that the prevalence of HBV infection among pregnant women in sub-Saharan Africa ranges between 2.4% in Ethiopia to 11.8% in Uganda [4][5][6][7]. Prior studies on HBV infection among pregnant women in Ghana found a prevalence of 7.9% and 9.5% in the middle and northern parts respectively [8,9].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Hepatitis B virus infection and associated factors among pregnant women at Korle-Bu Teaching Hospital, Ghana

Dortey¹,

Anaba

Lassey

et al. 2020

PLoS ONE

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Introduction Hepatitis B virus infection is a global public health problem. Though, the disease is endemic in sub-Saharan Africa, little is known about its epidemiology among pregnant women in Ghana. This study sought to determine the seroprevalence of Hepatitis B virus infection and associated factors among pregnant women attending antenatal care at Korle-Bu Teaching Hospital; Ghana's largest hospital. Methods We conducted a facility-based cross-sectional survey among 232 antenatal attendants. Participants were recruited using systematic random sampling technique and screened with HBsAg Rapid Test. Data was analyzed with the aid of Statistical Package for Social Sciences (SPSS), version 23.0. Results were presented using descriptive statistics, Fisher's Exact test and Logistic Regression analysis. Results Two hundred and twenty-one (221) of the total sample (n = 232) agreed to participate in this study; representing a response rate of 95%. The mean age of the participants was 31 years and standard deviation of 5.3. The mean gestational period at recruitment was 28 weeks and standard deviation of 6.8. Majority of the participants were married (83.3%), parous (69.6%), educated (91.4%) and employed (90.5%). The prevalence of HBsAg was 7.7%. We found no significant association between socio-demographic characteristics of the participants and HBV infection. Conclusion Seroprevalence of 7.7% indicates moderate endemicity. Socio-demographic characteristics did not influence HBV infection among pregnant women attending antenatal care at Korle

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“…Even if the study design is similar, Variations in the prevalence of HBV infection within different parts of the world may be due to differences in the methods used for screening for HBsAg, sample size difference, local government attention for the virus, and cultural and behavioral differences regarding possible risk factors of HBV infection.With regard to socio-demographic status of study participants, high prevalence 7 (9.72%) of HBV infection was observed among pregnant women of age 16 to 20 years and low prevalence observed among those with age of 21 and above years, but the difference was not statistically significant. The observed high prevalence of HBV positivity among younger age group could be defined with the high probability of exposure for high risk health behavior but this is contrasted with other studies because high prevalence of HBV infection was found on the study subjects of age greeter than 20 years [11, 22, 23]. Concerning levels of education, it was noted that high prevalence 12 (15%) of HBV infection was detected among pregnant women who had primary educational [1–8] status and the low prevalence 1 (5.26%) of HBV infection among those who cannot read and write may be due to their low number in the study.…”

Section: Discussionmentioning

confidence: 78%

“…Areas with high magnitude of HBsAg sero-prevalence include 16.5 % in Nigeria and 10.2% in Cameroon [7, 21]. Some of the areas in which low prevalence of HBV infection detected were 3.1% in Rwanda ,4.3% in Arba Minch and 4.9% in Dessie [9, 12, 22]. Even if the study design is similar, Variations in the prevalence of HBV infection within different parts of the world may be due to differences in the methods used for screening for HBsAg, sample size difference, local government attention for the virus, and cultural and behavioral differences regarding possible risk factors of HBV infection.With regard to socio-demographic status of study participants, high prevalence 7 (9.72%) of HBV infection was observed among pregnant women of age 16 to 20 years and low prevalence observed among those with age of 21 and above years, but the difference was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Sero-prevalence of hepatitis B virus and associated factors among pregnant women in Gambella hospital, South Western Ethiopia: facility based cross-sectional study

et al. 2019

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Background Hepatitis B virus (HBV) is a hepatotropic deoxyribonucleic acid (DNA) virus which causes death. More than 300 million people have chronic liver infections globally and about 600,000 people die annually from acute or chronic complications of hepatitis B infection. Recent studies conducted in Ethiopia showed moderate endemicity (3–7.8%) of HBV among pregnant women. However, there is paucity of information on sero- prevalence of HBV and associated factors among pregnant women at Gambella town. The aim of this study is to assess sero-prevalence of hepatitis surface antigen (HBsAg) and associated factors among pregnant women in Gambella Hospital. Methods Hospital based cross-sectional study was conducted in a total of 253 pregnant women from March 10–April 15, 2017. Socio-demographic characteristics and risk factors were collected through face to face interview using structured questionnaire. HBV infection was determined using Eugene strip test. Logistic regression analysis was used to determine association between HBsAg sero-positivity and various factors. Findings were presented using 95% CI of Crude Odds Ratios (COR) and Adjusted Odds Ratios (AOR). Result The overall sero- prevalence of HBV infection was 7.9% (95% CI, 4.7–11.9), which indicates intermediate endemicity. History of abortion (AOR = 3.56:1: 95% CI, 1.24–10.22), occupation (AOR = 8.36:95% CI, 1.67–41.96) and multiple sexual partner (AOR = 17.38: 95% CI, 4.48–67.49) had statistical significant association with HBsAg sero-positivity. Conclusion HBV sero-prevalence in pregnant women shows intermediate endemicity. Hence health education on having single sexual partner and risk factors of abortion should be given. In addition, routine screening and immunization of pregnant women for HBV infection should be strengthen.

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Seroprevalence of hepatitis B among pregnant women in Kigali, Rwanda

Cited by 7 publications

References 11 publications

Prevalence and Factors Associated with Hepatitis B Surface Antigen Positivity among Women Receiving Antenatal Care at Mbarara Regional Referral Hospital

Prevalence and Factors Associated with Hepatitis B Surface Antigen Positivity among Women Receiving Antenatal Care at Mbarara Regional Referral Hospital

Seroprevalence of Hepatitis B virus infection and associated factors among pregnant women at Korle-Bu Teaching Hospital, Ghana

Sero-prevalence of hepatitis B virus and associated factors among pregnant women in Gambella hospital, South Western Ethiopia: facility based cross-sectional study

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