Seroprevalence of Hepatitis A and Associated Socioeconomic Factors in Young Healthy Korean Adults

Chung, Gyung Ho; Yim, Jeong Yoon; Kim, Dong‐Hee; Lim, Seon Hee; Park, Min Jung; Kim, Young Sun; Yang, Sun Young; Yang, Jong In; Cho, Sang Heon

doi:10.5009/gnl.2011.5.1.88

Cited by 14 publications

(11 citation statements)

References 19 publications

(19 reference statements)

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“…Seroepidemiologic differences between urban and rural areas as well as among income levels were also observed in previous studies. [17, 18]…”

Section: Discussionmentioning

confidence: 99%

Nationwide Seropositivity of Hepatitis A in Republic of Korea from 2005 to 2014, before and after the Outbreak Peak in 2009

Kim

Lee

et al. 2017

PLoS ONE

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Background/AimsThe epidemiologic shift of hepatitis A virus (HAV) infection in the South Korean population resulted in a peak outbreak of hepatitis in 2009. The aim of this study was to clarify the seropositivity of anti-HAV antibody (anti-HAV) and its demographic characteristics before and after the peak outbreak from 2005 to 2014.MethodsThis retrospective study analyzed the anti-HAV data of all individuals from 1,795 medical institutions referred to a major central laboratory from January 2005 through December 2014, as a sentineal tool for monitoring annual variation of anti-HAV positivity. The prevalence of anti-HAV was adjusted for age and area with the standard population based on the 2010 Census data.ResultsA total of 424,245 individuals were included in this study. The overall age-adjusted anti-HAV prevalence decreased from 65.6% in 2005 to 62.2% in 2014. During the 10-year period, the seroprevalence continuously decreased in persons aged 30 to 39 years (69.6% to 32.4%) and those aged 40 to 49 years (97.9% to 79.3%) due to the cohort effect. In contrast, it increased in persons aged 10 to 19 years (15.4% to 35.2%), while it was the lowest (8.7%) in 2010 before rebounding to 20.2% in 2014 in persons aged 20 to 29 years due to a vaccination effect.ConclusionAlthough the HAV vaccination rate increased, the anti-HAV seropositivity in South Korea decreased from 65.6% to 62.2% in this study population. In particular, the immunity of young adults was still low, and an outbreak of HAV is possible in the near future. Therefore, continuous monitoring and optimal preventive measures to prevent future outbreaks should be considered.

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“…Seroepidemiologic differences between urban and rural areas as well as among income levels were also observed in previous studies. [17, 18]…”

Section: Discussionmentioning

confidence: 99%

Nationwide Seropositivity of Hepatitis A in Republic of Korea from 2005 to 2014, before and after the Outbreak Peak in 2009

Kim

Lee

et al. 2017

PLoS ONE

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“…A baixa prevalência de anticorpos em idades menores preocupa pelo risco de surtos ou epidemias em creches e escolas, bem como a possibilidade de essa população se infectar em idades mais avançadas, fase em que a doença pode ser mais grave 27 .…”

Section: Parâmetrounclassified

“…Fica evidente que é fundamental o investimento nas melhorias das condições socioeconômicas e culturais, porém deve ser ressaltado que essas melhorias são lentas, levando anos para ocasionar mudanças 27 .…”

Section: Conclusãounclassified

Seroprevalence of hepatitis A in children and adolescents

et al. 2011

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Objectives: To determine the seroprevalence of hepatitis A (HAV) in children and adolescents aged 1 to 14 years, and to identify factors associated with a history of infection.Methods: This was a cross-sectional epidemiological study, conducted form February to August 2006 in the city of Curitiba, Paraná, Brazil, and the surrounding municipalities (Greater Curitiba). Laboratory analysis comprised qualitative assay for total HAV antibodies in whole blood samples.Results: A total of 901 children and adolescents were recruited for the study. Age distribution was as follows: 1 to 4 years, n = 237 (26.3%); 5 to 9 years, n = 313 (34.7%); and 10 to 14 years, n = 351 (39%). The global rate of seroprevalence was 19.8%, and seroprevalence rates by age group were 3%, 21.1% and 29.9% respectively (p < 0.01). Multivariate analysis demonstrated that the following factors, in combination, had a positive association with the prevalence rate of antibodies against HAV in the study population: age groups 5 to 9 and 10 to 14 years, living in a household with more than one inhabitant per room, shared eating area and low per capita income. Conclusions:The results show a low prevalence of antibodies against HAV, which justifies the use of prophylactic measures, including early vaccination. J Pediatr (Rio J). 2011;87(5):419-24:Hepatitis A, seroepidemiological study, child, adolescent. ResumoObjetivos: Avaliar a soroprevalência de hepatite A (VHA) em crianças e adolescentes com idade entre 1 e 14 anos, e identificar fatores associados à infecção prévia.Métodos: Estudo epidemiológico transversal, realizado entre fevereiro e agosto de 2006, em Curitiba, Paraná, Brasil, e em sua região metropolitana. A análise laboratorial constituiu-se de pesquisa qualitativa de anticorpos totais para o VHA em amostra de sangue total. Resultados: No estudo, 901 crianças e adolescentes foram incluídos.A distribuição por faixa etária foi: 237 (26,3%) entre 1 e 4 anos; 313 (34,7%) entre 5 e 9 anos; e 351 (39%) entre 10 e 14 anos. A taxa de soroprevalência geral encontrada foi de 19,8%, e por grupo etário foi de 3, 21,1 e 29,9% (p < 0,01), respectivamente. Na análise multivariada, demonstrou-se que os fatores que, em conjunto, mantiveram associação positiva com as prevalências de anticorpos contra o VHA na população estudada foram: faixa etária de 5 a 9 e 10 a 14 anos, morar em casas com um ou mais habitantes por cômodo, frequentar refeitório comunitário e ter baixa renda per capita. Conclusões:Os resultados demonstraram uma baixa prevalência de anticorpos contra o VHA, o que justifica o uso de medidas profiláticas, que incluem a vacinação precoce. J Pediatr (Rio J). 2011;87(5):419-24:Hepatite A, estudo soroepidemiológico, criança, adolescente. Seroprevalence of hepatitis A in children and adolescents IntroduçãoO vírus da hepatite A (VHA) é o maior responsável por quadros de hepatite aguda viral em crianças 1 e também é responsável por 75% de todos os casos de hepatite viral no mundo. Essa doença apresenta distribuição mundial, ocorrendo com maior fr...

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“…Despite the recommendation, the immunization rate is very low among young adults (9). In a local study, the prevalence of seropositive individuals was just 6.2% in the 20-29 age group (10). Hepatitis A cases in Korea have been increasing since 1998, as shown in the number of patients who receive liver transplants or death due to the disease (11).…”

Section: Introductionmentioning

confidence: 98%

Risk Factors for Acute Hepatitis A Infection in Korea in 2007 and 2009: A Case-Control Study

Seo

Choi

et al. 2013

J Korean Med Sci

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This study aimed to identify the risk factors associated with acute hepatitis A virus (HAV) infection in the Korean population. Participants were recruited from five referral hospitals across the country in 2007 and from 11 hospitals in 2009. Patients with positive anti-HAV IgM antibody tests became the case group, while patients treated for non-contagious diseases at the same hospitals were recruited as controls. A total of 222 and 548 case-control pairs were studied in the 2007 and 2009 surveys, respectively. Data from the surveys were analyzed jointly. In a multivariate analysis, sharing the household with HAV-infected family members (OR, 6.32; 95% CI, 1.4-29.6), contact with other HAV-infected individuals (OR, 4.73; 95% CI, 2.4-9.4), overseas travel in 2007 (OR, 19.93; 95% CI, 2.3-174.4), consumption of raw shellfish (OR, 2.51; 95% CI, 1.8-3.5), drinking bottled water (OR, 1.64; 95% CI, 1.3-8.4), and occupation that involve handling food (OR, 3.30; 95% CI, 1.3-8.4) increased the risk of HAV infection. Avoiding contact with HAV-infected individuals and avoiding raw foods eating could help minimize the risk of hepatitis A infection. Immunization must be beneficial to individuals who handle food ingredients occupationally or travel overseas to HAV-endemic areas.

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Seroprevalence of Hepatitis A and Associated Socioeconomic Factors in Young Healthy Korean Adults

Cited by 14 publications

References 19 publications

Nationwide Seropositivity of Hepatitis A in Republic of Korea from 2005 to 2014, before and after the Outbreak Peak in 2009

Nationwide Seropositivity of Hepatitis A in Republic of Korea from 2005 to 2014, before and after the Outbreak Peak in 2009

Seroprevalence of hepatitis A in children and adolescents

Risk Factors for Acute Hepatitis A Infection in Korea in 2007 and 2009: A Case-Control Study

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