Seroprevalence of cytotoxin‐associated gene A positive <i>Helicobacter pylori</i> strains in Changle, an area with very high prevalence of gastric cancer in South China

Wong, Benjamin C Y; Lam, Shiu Kum; Ching, C. K.; Hu, Whc; Ong, LY; Chen, B. W.; Gao, Zhendong; Chen, J. S.; Jiang, Xuefeng; Hou, XH; Lu, Jiongbin; Wang, W. H.; Ho, Jonathan K.; Yuen, Siu Tsan; Lai, K. C.; Kwok, E; Hui, W. M.; Covacci, Antonello

doi:10.1046/j.1365-2036.1999.00619.x

Cited by 16 publications

(14 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This issue is of particular importance in Asian countries, which have a high prevalence of gastric cancer 16 ,. 17 A lower dosage of proton pump inhibitor with less suppression of intragastric pH, but with a satisfactory reduction in oesophageal acid exposure, may theoretically be ideal for the treatment of acid‐related disorders in a population with a high risk of gastric cancer development. Furthermore, there is a potential cost saving in terms of drug costs with low‐dose proton pump inhibitors.…”

Section: Discussionmentioning

confidence: 99%

Double‐blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24‐h oesophageal and intragastric pH in Chinese subjects with gastro‐oesophageal reflux disease

Wong¹,

Lai²,

Hui³

et al. 2004

Aliment Pharmacol Ther

View full text Add to dashboard Cite

SUMMARYBackground: Previous studies have suggested that the acid secretory capacity of the Chinese population is lower than that of the Western population. Aim: To compare the effect of lansoprazole 30 mg and 15 mg once daily on the 24-h oesophageal and intragastric pH profiles in Chinese patients with gastrooesophageal reflux disease. Methods: Forty-four patients (male to female ratio, 27 : 17; mean age, 53 years; 55% with oesophagitis) with gastro-oesophageal reflux disease were randomized to receive lansoprazole 30 mg or 15 mg once daily for 4 weeks. Measurement of the 24-h oesophageal and intragastric pH, gastro-oesophageal reflux disease symptoms and quality of life was performed at baseline and during the last week of each dosing period.

show abstract

Section: Discussionmentioning

confidence: 99%

Double‐blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24‐h oesophageal and intragastric pH in Chinese subjects with gastro‐oesophageal reflux disease

Wong¹,

Lai²,

Hui³

et al. 2004

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

“…Studies done in the West have concluded that infection with cagA ‐positive H. pylori strains is associated with an increased risk of development of atrophic gastritis and intestinal metaplasia [12,13], and hence malignant disease. However, in many parts of Asia, the majority of H. pylori are cagA ‐positive [24–27]. Several studies done in Asian populations have not shown any significant association between cagA and the development of gastric adenocarcinoma [14,15,27,28] because of the background of high prevalence of cagA ‐positive strains in the community.…”

Section: Discussionmentioning

confidence: 99%

Seroreactivity to 19.5‐kDa Antigen in Combination with Absence of Seroreactivity to 35‐kDa Antigen is Associated with an Increased Risk of Gastric Adenocarcinoma

et al. 2002

View full text Add to dashboard Cite

show abstract

“…The prevalence of cagA in Asia is high, and currently identified cagA genotypes in the Asia-Pacific region have not been associated with gastric cancer. [70][71][72][73][74][75][76] As such, there is no role for it as a marker for gastric cancer risk in an individual.…”

Section: Statement 17: Neither Caga Serology Nor the Presence Of The mentioning

confidence: 99%

“…Gastric cancer of the cardia was not associated with H. pylori infection or cagA ‐positive strains of H. pylori . However, the prevalence of cagA in Asia is high, and currently identified cagA genotypes in the Asia–Pacific region are not associated with gastric cancer 69–76 …”

Section: Consensus Statementsmentioning

confidence: 99%

Asia–Pacific consensus guidelines on gastric cancer prevention

Fock

Talley

Martin

et al. 2008

J of Gastro and Hepatol

303

265

View full text Add to dashboard Cite

Background and Aim: Gastric cancer is a major health burden in the Asia-Pacific region but consensus on prevention strategies has been lacking. We aimed to critically evaluate strategies for preventing gastric cancer. Methods: A multidisciplinary group developed consensus statements using a Delphi approach. Relevant data were presented, and the quality of evidence, strength of recommendation, and level of consensus were graded. Results:Helicobacter pylori infection is a necessary but not sufficient causal factor for non-cardia gastric adenocarcinoma. A high intake of salt is strongly associated with gastric cancer. Fresh fruits and vegetables are protective but the use of vitamins and other dietary supplements does not prevent gastric cancer. Host-bacterial interaction in H. pylori infection results in different patterns of gastritis and differences in gastric acid secretion which determine disease outcome. A positive family history of gastric cancer is an important risk factor. Low serum pepsinogens reflect gastric atrophy and may be useful as a marker to identify populations at high risk for gastric cancer. H. pylori screening and treatment is a recommended gastric cancer risk reduction strategy in high-risk populations. H. pylori screening and treatment is most effective before atrophic gastritis has developed. It does not exclude the existing practice of gastric cancer surveillance in high-risk populations. In populations at low risk for gastric cancer, H. pylori screening is not recommended. Firstline treatment of H. pylori infection should be in accordance with national treatment guidelines. Conclusion: A strategy of H. pylori screening and eradication in high-risk populations will probably reduce gastric cancer incidence, and based on current evidence is recommended by consensus.

show abstract

Seroprevalence of cytotoxin‐associated gene A positive Helicobacter pylori strains in Changle, an area with very high prevalence of gastric cancer in South China

Cited by 16 publications

References 16 publications

Double‐blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24‐h oesophageal and intragastric pH in Chinese subjects with gastro‐oesophageal reflux disease

Double‐blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24‐h oesophageal and intragastric pH in Chinese subjects with gastro‐oesophageal reflux disease

Seroreactivity to 19.5‐kDa Antigen in Combination with Absence of Seroreactivity to 35‐kDa Antigen is Associated with an Increased Risk of Gastric Adenocarcinoma

Asia–Pacific consensus guidelines on gastric cancer prevention

Contact Info

Product

Resources

About