Double‐blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24‐h oesophageal and intragastric pH in Chinese subjects with gastro‐oesophageal reflux disease

Wong, Wai Man; Lai, K. C.; Hui, W. M.; Lam, Kwok–Fai; Huang, Jia; Hu, W. H. C.; Wong, Nina; Lam, Carlos; Xia, Harry Hua‐Xiang; Chan, Annie On‐On; Lam, Shiu Kum; Wong, Benjamin Chun–Yu

doi:10.1046/j.1365-2036.2004.01846.x

Cited by 18 publications

(11 citation statements)

References 24 publications

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“…GERD is less prevalent in Asian countries and the perception is that Asians tend to have a milder spectrum of the disease. A lower dose of PPI has been suggested to be sufficient for the control of symptoms in Chinese compared with the Western population [8]. In this study, 75.8% of patients had complete symptom resolution after 8 weeks of esomeprazole 20 mg daily which is consistent with previous studies.…”

Section: Discussionsupporting

confidence: 91%

“…The degree of acid suppression required for the control of GERD symptoms may be different from that in the Western population. It has been shown that lansoprazole 15 mg once daily provides a satisfactory decrease for oesophageal acid exposure and is equally effective for the treatment of GERD in the Chinese population as compared with the usual standard dose of 30 mg once daily [8]. However, no study has been performed to assess if a reduced dose of proton pump inhibitor (PPI) would be adequate for symptom resolution and healing of oesophagitis in Chinese patients.…”

Section: Introductionmentioning

confidence: 99%

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Symptom Resolution Does Not Predict Healing of Erosive Oesophagitis in Chinese

Cheung¹,

Wong²,

Wong³

et al. 2007

Digestion

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Background: Previous studies suggested that Chinese have a milder spectrum of gastro-oesophageal reflux disease and a lower dose of proton pump inhibitors (PPI) is sufficient for the control of symptoms as compared with the Western population. Aims: To determine if 8 weeks of esomeprazole 20 mg daily would be adequate for both symptom resolution and oesophagitis healing in Chinese patients and the predictive factors for the response. Methods: 66 patients with oesophagitis were included. Oesophagitis severity was graded by Los Angeles (LA) classification. 61 patients underwent 24-hour ambulatory pH study at baseline. All were given esomeprazole 20 mg daily for 8 weeks. Symptom response and healing of oesophagitis was assessed at the end of the treatment period. Results: 75.8% of the patients had complete reflux symptom resolution but only 48% had complete healing of the oesophagitis at endoscopy after 8 weeks of treatment. LA classification grading at baseline endoscopy (p < 0.0001) and total number acid reflux episodes on 24-hour pH monitoring prior to treatment (p = 0.007) were both good predictors of oesophagitis healing but not for symptom resolution. Conclusions: Our results suggested that 8 weeks of lower dose PPI is not sufficient for oesophagitis healing. Symptom resolution with PPI does not predict oesophagitis healing in Chinese.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Symptom Resolution Does Not Predict Healing of Erosive Oesophagitis in Chinese

Cheung¹,

Wong²,

Wong³

et al. 2007

Digestion

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“…We have shown that typical reflux syndromes and reflux-related non-cardiac chest pain cause significant psychological impact and worsening of the quality of life (QOL) of the sufferers [4,5,6]. Treatment can lead to improvement not only in the symptoms, but the patients’ QOL [7]. The impact of LPR on the psychological well-being and QOL of its sufferers is not well studied in the Chinese population, and the aims of this study were to assess and compare the QOL and psychological impact of LPR on patients and healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Patients with Laryngopharyngeal Reflux

Cheung¹,

Lam²,

Wei³

et al. 2008

Digestion

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Background: Laryngopharyngeal reflux (LPR) disease is an extraesophageal manifestation of gastroesophageal reflux disease (GERD). The impact of GERD-related LPR on the psychological well-being and quality of life (QOL) in Chinese is not known. Aim: To assess the QOL in patients with LPR disease. Methods: 76 LPR and 73 healthy subjects were recruited. Psychological well-being was assessed by the Hospital Anxiety and Depression Score and QOL was assessed by SF-36. Results: 51/76 (67.1%) patients had GERD-related LPR. More LPR subjects had taken sick leave (36.2 vs. 5.6%, p = 0.001) and reported adverse social life impact (60.5 vs. 38.9%, p = 0.013). LPR patients showed significantly worse results on the Voice Handicap Index (47.8 vs. 7.6, p = 0.001), were more anxious and had worse QOL in social functioning, pain and general health perception domains of SF-36. GERD-related LPR subjects had a higher depression score (4.8 vs. 3.8, p = 0.014) and a lower mental summary score (41.8 vs. 48.4, p = 0.01) in SF-36 compared with those without GERD. Conclusions: LPR had a negative impact on psychological status, social functioning and QOL. GERD symptoms appeared to be the main contributor to decrease QOL. GERD-related LPR patients had a significant impact on the mental component of their QOL.

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“…Numerous studies and meta-analyses have confirmed the efficacy of intravenous pantoprazole in treating peptic ulcer bleeding and stress ulcer bleeding, and thus pantoprazole is now one of the PPIs most used intravenously in treating non-variceal gastrointestinal bleeding. Lansoprazole is also a newly developed PPI with high effectiveness in controlling intragastric acid and in treating acid-related upper gastrointestinal diseases [20–26]. Several clinical trials have been conducted to compare the effect on intragastric acid control by oral lansoprazole with that by either oral or intravenous pantoprazole in healthy volunteers and patients with GERD [27–30].…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of intravenous lansoprazole 30 mg and pantoprazole 40 mg twice daily on intragastric acidity in healthy Chinese volunteers: A randomized, open-labeled, two-way crossover study

Zhan

Guo

et al. 2012

Med Sci Monit

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SummaryBackgroundUntil now there has been no study that directly compares the effect of lansoprazole and pantoprazole administered intravenously on intragastric acidity. The aim of this study is to compare the effect of lansoprazole (30 mg) and pantoprazole (40 mg) administered intravenously on gastric acidity.Material/MethodsHelicobacter pylori-negative healthy volunteers were recruited in this open-label, randomized, two-way crossover, single centre study. Lansoprazole at 30 mg or pantoprazole at 40 mg was intravenously administered twice daily for 5 consecutive days with at least a 14-day washout interval. Twenty-four-hour intragastric pH was continuously monitored on days 1 and 5 of each dosing period.ResultsTwenty-five volunteers completed the 2 dosing periods. The mean intragastric pH values were higher in subjects treated with lansoprazole than those with pantoprazole on both day 1 (6.41±0.14 vs. 5.49±0.13, P=0.0003) and day 5 (7.09±0.07 vs. 6.64±0.07, P=0.0002). Significantly higher percentages of time with intragastric pH >4 and pH >6 were found in the subjects treated with lansoprazole than those with pantoprazole on day 1 (pH >4, 87.12±4.55% vs. 62.28±4.15%, P=0.0012; pH >6, 62.12±4.12% vs. 47.25±3.76%, P=0.0216) and pH >6 on day 5 (76.79±3.77% vs. 58.20±3.77%, P=0.0025).ConclusionsIntravenous lansoprazole produces a longer and more potent inhibitory effect on intragastric acidity than does intravenous pantoprazole.

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Double‐blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24‐h oesophageal and intragastric pH in Chinese subjects with gastro‐oesophageal reflux disease

Cited by 18 publications

References 24 publications

Symptom Resolution Does Not Predict Healing of Erosive Oesophagitis in Chinese

Symptom Resolution Does Not Predict Healing of Erosive Oesophagitis in Chinese

Quality of Life in Patients with Laryngopharyngeal Reflux

Inhibitory effects of intravenous lansoprazole 30 mg and pantoprazole 40 mg twice daily on intragastric acidity in healthy Chinese volunteers: A randomized, open-labeled, two-way crossover study

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