Seroprevalence of Cytomegalovirus among blood donors and antenatal women attending two hospitals in Khartoum State

Abstract

Back ground: Cytomeglovirus(CMV) is a common viral infection globally. Although most infections are subclinical; infection during pregnancy may be associated with serious outcome such as abortion, stillbirth and congenitally malformed child. Methods and results: During the period from June to July2003, 250 subjects (150 blood donors and 100 women presenting to Khartoum Teaching Hospital's and Omdurman Maternity Hospital respectively)had their blood tested for IgG antibodies against Cytomegalovirus using ELISA test. Of these 84% were found to harbor Cytomegalovirus antibodies. The seroprevalence of the virus was higher in the antenatal women (95%) compared to the blood donors (77%). Conclusion: The study revealed insignificant association between infection with the virus and both history of previous surgical operation and blood transfusion (p> 0.05).CMV infection was found to be associated with increased risk of abortion in women under study.

Primary Cytomegalovirus Infection in Pregnant Egyptian Women Confirmed by Cytomegalovirus IgG Avidity Testing

“…The estimated seroprevalence of CMV IgM was high, indicating the likelihood of an endemic nature of infection in the Suez Canal Area of Egypt, and confirmed the ubiquitous past exposure to infection in the Suez Canal area. Our results also confirmed data of previous studies from Egypt and other Middle Eastern countries [ 3 , 6 , 14 , 15 ]. In a study from Iran by Bagheri et al [ 3 ], the majority of pregnant women (72.1%) were positive for CMV IgG and 2.5% were positive for CMV IgM.…”

“…In a study in Egypt [ 14 ], there were no cases of primary CMV diagnosed in 132 pregnant women, and only 4.5% of these women were diagnosed with recurrent CMV infection, which was defined as being IgG positive prior to pregnancy, IgG positive at the first pregnancy visit without IgM test, or IgM positive with high IgG avidity. In Sudan [ 15 ], it was reported that CMV seroprevalence among antenatal women was 84%.…”

Association Between Cytomegalovirus Infection and Bad Obstetric Outcomes in Women from Kirkuk

“…However, our study susceptibility was lower than that reported for France [31], Nepal [32], India [13], [33], [34], Switzerland [35], Croatia [36], Malaysia [37], Iran [12], [38], Poland [39], Ireland [10], Russia [40], Taiwan [41], Germany [42], Azerbaijan [43], Bangladesh [44], and Brazil [45]. In comparison to Arab countries, this study susceptibility rate was lower to that reported for Egypt [46], Sudan [47], Syria [48], and Jordan [15], but similar to that reported for Saudi Arabia [49], and higher to rate in Qatar [50], Sudan [51], and Tunisia [52].…”

Human cytomegalovirus infection in Nigerians living with human immunodeficiency virus

“…The results of our study were generally consistent with those of other reports from developing countries where HCMV infection occurs particularly in immune-compromised individuals. [23][24][25][26][27] We therefore report for the first time in Nigeria, a study evaluating the prevalence of HCMV infection by qualitative PCR in HIV infected patients.…”