Seroprevalence of canine herpesvirus in breeding kennels in the Gauteng Province of South Africa

Nöthling, J.O.; Hüssy, Daniela; Steckler, Daniela; Ackermann, Mathias

doi:10.1016/j.theriogenology.2007.09.022

Cited by 30 publications

(29 citation statements)

References 19 publications

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“…CHV was first described in 1965 as a pathogen responsible for a fatal generalized hemorrhagic disease of newborn pups (5). The host range of CHV is generally restricted to domestic and wild Canidae (11), and the worldwide distribution of CHV infection in domestic dog populations has been shown by virus isolation (2,7,10,12,24,27) and seroepidemiological studies (6,25,28,30,31,34). It is now well recognized that the pathogenic potential of CHV is mostly influenced by the age of the host (11).…”

mentioning

confidence: 99%

Nosocomial Outbreak of Serious Canine Infectious Tracheobronchitis (Kennel Cough) Caused by Canine Herpesvirus Infection

Kawakami

Ogawa²,

Maeda

et al. 2010

J Clin Microbiol

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Canine herpesvirus (CHV; Canid herpesvirus 1) is principally a perinatal pathogen of pregnant bitches and newborn pups and secondarily a respiratory tract pathogen of older pups and dogs. Infectious disease of the canine respiratory tract frequently occurs among dogs in groups, in which it is called " infectious tracheobronchitis" (ITB). Mortality from ITB is generally negligible, and the clinical importance of CHV as an ITB pathogen is considered to be low. The present report describes a novel ITB outbreak accompanied by death among aged dogs in an animal medical center. Most inpatient dogs had received medications that could induce immunosuppression. CHV was the only pathogen identified, and several CHV isolates were recovered in cell culture. No other viral pathogens or significant bacterial pathogens were found. Molecular and serological analyses revealed that the causative CHV isolates were from a single source but that none was a peculiar strain when the strains were compared with previous CHV strains. The virus had presumably spread among the dogs predisposed to infection in the center. The present results serve as a warning to canine clinics that, under the specific set of circumstances described, such serious CHV outbreaks may be expected wherever canine ITB occurs.

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confidence: 99%

Nosocomial Outbreak of Serious Canine Infectious Tracheobronchitis (Kennel Cough) Caused by Canine Herpesvirus Infection

Kawakami

Ogawa²,

Maeda

et al. 2010

J Clin Microbiol

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“…Almost the same set had previously been used for determining the seroprevalence of canine herpesvirus 1 in Gauteng Province (29). In that study, canine herpesvirus 1-positive dogs were found in 45% of the kennels and the prevalence of seropositive dogs in affected kennels was close to 40%.…”

Section: Discussionmentioning

confidence: 89%

“…The sera were taken from patients presented for various conditions unrelated to PV infections. The second set containing 315 sera was originally collected at three different veterinary practices in Gauteng Province, South Africa, between May and June 2005 in order to determine the prevalence of antibodies against canine herpesvirus in the serum of dogs older than 1 year in breeding kennels (29). Between 3 and 20 samples from different dogs were available from each of 36 kennels.…”

mentioning

confidence: 99%

Detection of Antibodies against Epidermodysplasia Verruciformis-Associated Canine Papillomavirus 3 in Sera of Dogs from Europe and Africa by Enzyme-Linked Immunosorbent Assay

Lange

Tobler

Favrot

et al. 2009

Clin Vaccine Immunol

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The role of papillomaviruses (PVs) in the development of canine cancers is controversial. However, recently a novel canine PV (CPV3) was detected in a dog affected with a condition reminiscent of epidermodysplasia verruciformis (EV). The aim of the present study was to investigate the seroprevalence of CPV3 by using generic enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies against either canine oral PV (COPV) or CPV3. Therefore, the capsid proteins of both PV types were expressed as glutathione S-transferase fusion protein antigens and adsorbed to glutathione-casein-coated ELISA plates. After showing that PV type-specific antibodies could be detected in the sera from dogs with confirmed COPV or CPV3 infection, CPV3-and COPV-seropositive samples were detected in two sets of canine sera collected in Switzerland and South Africa, respectively. We found specific antibodies against COPV and CPV3 among the tested sera and also a large number that were positive for both antigens. The seroprevalences of PV antibodies of 21.9% (COPV) and 26.9% (CPV3) among the tested dogs from South Africa were higher than those among the dogs from Switzerland at 10.5% (COPV) and 1.3% (CPV3). Our data suggest a need for further CPV-related seroepidemiological surveys in different countries, especially in the context of clinical manifestations and possible breed predispositions. For this purpose, the newly developed ELISAs can be a useful tool.Papillomaviruses (PVs) are small, icosahedral, nonenveloped DNA viruses with mucosal and skin tropism which are associated with various hyperplastic, dysplastic, and neoplastic conditions in humans and animals (21). More than 100 types of human PVs (HPVs) have been described, and more are continuously being discovered (8). The role of HPVs in the development of human diseases, i.e., cervical carcinomas or epidermodysplasia verruciformis (EV)-associated skin carcinomas, is well established, and pathomechanisms have been the focus of many studies (14,23,30,35,48). Indeed, both PCR-and enzyme-linked immunosorbent assay (ELISA)-based techniques are commonly used to carry out HPV-related epidemiologic studies (2, 25).In contrast, the role of PVs in the development of canine cancers remains uncertain, although a clinical counterpart to human EV has been described in dogs with PV infections (28). Until now, only four canine PVs (CPVs) have been unambiguously identified and sequenced (7,42,43,46). The first and best-known CPV, canine oral PV (COPV), affects mostly juvenile dogs and causes warts with a typical cauliflower-like appearance located in the oral cavity and other mucous membranes (32). Since COPV-affected dogs recover spontaneously and specific antibodies protect them from reinfection, COPV infection is not considered a life-threatening condition (32). Although COPV infection is endemic in most dog populations, there never was a great demand for serological surveys, and systematic serological data concerning the prevalence of COPV infection are thus far unavailable. A dis...

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“…The involvement of herpesvirus in naturally occurring infertility and pregnancy losses [20] in the bitch is controversial; however, there is more and more evidence regarding the implication of this agent in cases of infertility [21][22][23][24]. The virus has been associated with reproductive failure if the dam is infected or reactivates during either estrus or the pregnancy.…”

Section: Canine Herpesvirus 1amentioning

confidence: 99%

“…Canine herpesvirus type 1 occurs in canine populations throughout the world, with serological studies demonstrating an incidence of up to 60-80% depending on the country [22,24,[41][42][43][44]. This incidence is probably underestimated, as serological testing only detects animals either recently infected or having reactivated the virus.…”

Section: Canine Herpesvirus 1amentioning

confidence: 99%

Canine and feline pregnancy loss due to viral and non-infectious causes: A review

2008

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Among the causes for pregnancy loss, viruses and non-infectious factors are among the most important. In both dogs and cats, research and clinical evidence provide proof that there is an increasing incidence of pregnancy loss associated with infectious diseases like herpesvirus, as well as the presence of toxicants or chemicals in the animal's diet and environment. Endocrine causes must be taken into consideration when dealing with pregnancy loss. This review will cover the most recent knowledge regarding viral and non-infectious of pregnancy losses in the dog and cat.

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Seroprevalence of canine herpesvirus in breeding kennels in the Gauteng Province of South Africa

Cited by 30 publications

References 19 publications

Nosocomial Outbreak of Serious Canine Infectious Tracheobronchitis (Kennel Cough) Caused by Canine Herpesvirus Infection

Nosocomial Outbreak of Serious Canine Infectious Tracheobronchitis (Kennel Cough) Caused by Canine Herpesvirus Infection

Detection of Antibodies against Epidermodysplasia Verruciformis-Associated Canine Papillomavirus 3 in Sera of Dogs from Europe and Africa by Enzyme-Linked Immunosorbent Assay

Canine and feline pregnancy loss due to viral and non-infectious causes: A review

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