Seroprevalence of anti HCV antibodies among blood donors in Kathmandu valley, Nepal

Karki, Surendra; Ghimire, Prakash; Tiwari, Bishnu Raj; Rajkarnikar, Manita

doi:10.3126/kumj.v6i4.1741

Cited by 21 publications

(27 citation statements)

References 16 publications

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“…Differences in HIV, HBV, HCV and Syphilis seroprevalence in Nepal compared to studies conducted in Ethiopia [1], Tanzania [22], Thailand [23] and Pakistan [24] must have been due to variations in geographical distribution as well as population differences in terms of lifestyle, awareness, sensitivity and specificity of tests, donor selection criteria, etc. The prevalence of HIV, HCV, and HBV also seems to be decreasing when compared to similar previous studies focussed on any of these infections conducted in Kathmandu, Nepal [5,[14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 80%

“…Mandatory screening tests are performed for human immunodeficiency virus (HIV) 1 and 2, hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis by blood transfusion centres in Nepal. HIV seroprevalence among blood donors in different regions of Nepal and Kathmandu Valley has been reported to range from 0.019% to 0.41% [4][5][6][7]. HBV seroprevalence has been reported to range from 0.3% to 4.0% in the general population of Nepal by various studies conducted from 1990 to 2003 [8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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Transfusion-transmissible infections among blood donors in Kathmandu, Nepal

Shrestha

Ghimire

Tiwari

et al. 2009

J Infect Dev Ctries

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Background: Screening of transfusion-transmissible infections (TTIs) among blood donors can be a cost-effective approach to monitor the prevalence, distribution, and trends of the infections among healthy-looking individuals. The study aimed to determine the seroprevalence of four TTIs, human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis, among blood donors in Kathmandu, Nepal. Methodology: A total of 21,716 units of blood were tested for the presence of anti-HIV 1/2 IgG/IgM, HBsAg, anti-HCV IgG/IgM, and antiTreponema pallidum IgG/IgM/IgA using commercial ELISA kits following standard protocols. Statistical analysis was performed using WinPepi Ver 3.8. Results: Seroprevalence of HIV, HBV (HBsAg), HCV and syphilis were observed to be 0.12% (95% CI = 0.08-0.18), 0.47% (95% CI = 0.39-0.57), 0.64% (95% CI = 0.54-0.75) and 0.48% (95% CI = 0.40-0.59) respectively. TTIs were dominant among male blood donors compared to female blood donors. Higher HCV seroprevalence among males compared to females was statistically significant. HIV prevalence was highest among blood donors in the age group 31 to 40 years (P > 0.5). HBV, HCV and syphilis prevalence was highest among blood donors 41 to 50 years age group, 21 to 30 years age group, and 51 to 60 years age group respectively (P < 0.05). HIV and HBV prevalence was relatively higher among first-time donors, whereas HCV and syphilis was relatively higher among the repeated donors (P > 0.05). Conclusions: It is of utmost importance to continue screening donated blood with highly sensitive and specific tests and to counsel donors who are positive to any of the above infections. It is absolutely necessary to avoid the transmission of infection from repeat donors.

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Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Transfusion-transmissible infections among blood donors in Kathmandu, Nepal

Shrestha

Ghimire

Tiwari

et al. 2009

J Infect Dev Ctries

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“…Each participant was informed of their test individually. In study, the past medical history of patients was taken since 2002 to 2012 till now, and regarding Nepal Blood Bank, Annual Progress Report of medical year 2011/012 is accessed for reference [19][20][21][22].…”

Section: Methodsmentioning

confidence: 99%

Evidence of Hepatitis C Virus Infection and Associated Treatment in Nepal

Nepal¹

2016

J Mol Biomark Diagn

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“…3 Different studies from Nepal showed that the sero-prevalence of HCV ranges from 0.35% to 1.73% in blood donors and healthy population with highest prevalence among injection drug users. [4][5][6][7][8] Six different HCV genotypes and multiple subtypes have been identified on the basis of molecular relatedness. …”

Section: Introductionmentioning

confidence: 99%

Clinical, Biochemical and Virological Profile of Patients with Chronic Hepatitis C Virus Infection - A Study from University Hospital in Nepal

Gurubacharya

Khadka²,

Shreshta³

et al. 2015

J Nobel Med Coll

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Introduction: Hepatitis C virus (HCV) infection is a major public health challenge. It is a major cause for cirrhosis and hepatocellular carcinoma worldwide. Both the genotype and viral load of HCV determine the choice of therapy as well as outcome of therapy. The aim of this study was to evaluate clinical, biochemical and virological profile and association of HCV genotypes with viral load and liver biochemical profile. Material and Methods:This was descriptive observational study of chronic HCV infected patients who attended at the outpatient clinic of Department of Gastroenterology of TUTH, IOM from April 2013 to November 2014. During this study period 38 patients with chronic HCV infection were analyzed. Clinical profile, possible risk factors for transmission of HCV infection and liver biochemical profile were recorded. Virological profile included HCV viral load and HCV genotypes. Results:Out of 38 patients 34(89.5%) were male and 4(10.5%) were female. Injection drug use (IDU) was the most common mode for acquisition of HCV infection (55.3%). Genotype 3 was found in 21(55.26%) patients and genotype 1 was found in 17(44.74%) patients. There was no significant association between HCV genotypes and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level. And also there was no significant association between HCV viral load and different HCV genotypes. Conclusions:In our study HCV genotype 3 was the most prevalent genotype in patients with chronic HCV infection. Injection drug use was identified as most common identifiable risk factor for transmission of HCV infection. There was no significant association between different HCV genotypes and serum ALT, AST level and HCV viral load.

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Seroprevalence of anti HCV antibodies among blood donors in Kathmandu valley, Nepal

Cited by 21 publications

References 16 publications

Transfusion-transmissible infections among blood donors in Kathmandu, Nepal

Transfusion-transmissible infections among blood donors in Kathmandu, Nepal

Evidence of Hepatitis C Virus Infection and Associated Treatment in Nepal

Clinical, Biochemical and Virological Profile of Patients with Chronic Hepatitis C Virus Infection - A Study from University Hospital in Nepal

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