Seroprevalence Dynamics of European Bat Lyssavirus Type 1 in a Multispecies Bat Colony

López-Roig, Marc; Bourhy, Hervé; Lavenir, Rachel; Serra‐Cobo, Jordi

doi:10.3390/v6093386

Cited by 23 publications

(22 citation statements)

References 31 publications

(55 reference statements)

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“…Had the first hypothesis been true, bat mortality would have been observed. However, these caves are periodically visited as a part of ongoing rabies studies [12] and no such mortalities have been observed [MLR, pers. obs.].…”

Section: Resultsmentioning

confidence: 99%

Widespread infection with hemotropic mycoplasmas in bats in Spain, including a hemoplasma closely related to “Candidatus Mycoplasma hemohominis”

Millán

López-Roig

Delicado

et al. 2015

Comparative Immunology, Microbiology and Infectious Diseases

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Molecular analyses of blood samples revealed infection with hemoplasmas in 97% of 31 cave bats captured in three caves in North-Eastern Spain. The characterization of 1250 bp of the 16S rRNA gene in 29 of the positive bats identified two different groups of sequences. Twenty-two Schreibers' bats (Miniopterus schreibersii) and one long-eared bat (Myotis capaccinii) shared one group, composed of seven closely related sequences. These sequences showed an identity of about 97% with "Candidatus Mycoplasma hemohominis" and the phylogenetic branch including bat and human sequences showed a 100% bootstrap value, supporting a close phylogenetic relationship between these hemoplasmas. The second group, representing a potentially novel species, was composed of a single sequence shared by six Schreibers' bats that had 91% identity with the recently reported hemoplasma from little brown bats in North America. Large bat aggregations in roosting caves probably benefits intra and inter-species transmission explaining the high observed prevalence.

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Section: Resultsmentioning

confidence: 99%

Widespread infection with hemotropic mycoplasmas in bats in Spain, including a hemoplasma closely related to “Candidatus Mycoplasma hemohominis”

Millán

López-Roig

Delicado

et al. 2015

Comparative Immunology, Microbiology and Infectious Diseases

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“…Bats are social animals that live in a densely populated roost, demographic and spatial structure of population with long life, which may significantly contribute to maintaining viruses as well as the high possibility of intra-and inter-species transmission of viral infections (Calisher et al, 2006). In addition, excreta during migration may be an important factor in the spread of viruses (López-Roig et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

The persistent prevalence and evolution of cross-family recombinant coronavirus GCCDC1 among a bat population: a two-year follow-up

Obameso

Jia

et al. 2017

Sci. China Life Sci.

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Bats are connected with the increasing numbers of emerging and re-emerging viruses that may break the species barrier and spread into the human population. Coronaviruses are one of the most common viruses discovered in bats, which were considered as the natural source of recent human-susceptible coronaviruses, i.e. SARS-COV and MERS-CoV. Our previous study reported the discovery of a bat-derived putative cross-family recombinant coronavirus with a reovirus gene p10, named as Ro-BatCoV GCCDC1. In this report, through a two-year follow-up of a special bat population in one specific cave of south China, we illustrate that Ro-BatCoV GCCDC1 persistently circulates among bats. Notably, through the longitudinal observation, we identified the dynamic evolution of Ro-BatCoV GCCDC1 in bats represented by continuously recombination events. Our study provides the first glimpse of the virus evolution in one longitudinally observed bat population cohort and underlines the surveillance and pre-warning of potential interspecies transmittable viruses in bats.

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“…Of the European bat lyssaviruses, type 1 (EBLV-1) has been the most studied but has been detected at a much lower frequency than RABV in the Americas, with a total of over 1000 cases reported over 30 years primarily in Eptesicus spp 14 . Studies of EBLV-1 dynamics have demonstrated seasonal and inter-annual variation in seroprevalence of between 11.1 and 40.2%, and demonstrated roost size and species richness are associated with higher seroprevalence [15][16][17] . Metapopulation models have suggested that inter-species transmission and migration behaviour have contributed to persistence of that virus 18,19 .…”

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confidence: 99%

Between roost contact is essential for maintenance of European bat lyssavirus type-2 in Myotis daubentonii bat reservoir: ‘The Swarming Hypothesis’

Horton

Breed

Arnold

et al. 2020

Sci Rep

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Many high-consequence human and animal pathogens persist in wildlife reservoirs. An understanding of the dynamics of these pathogens in their reservoir hosts is crucial to inform the risk of spill-over events, yet our understanding of these dynamics is frequently insufficient. Viral persistence in a wild bat population was investigated by combining empirical data and in-silico analyses to test hypotheses on mechanisms for viral persistence. A fatal zoonotic virus, European Bat lyssavirus type 2 (EBLV-2), in Daubenton's bats (Myotis daubentonii) was used as a model system. A total of 1839 M. daubentonii were sampled for evidence of virus exposure and excretion during a prospective nine year serial cross-sectional survey. Multivariable statistical models demonstrated age-related differences in seroprevalence, with significant variation in seropositivity over time and among roosts. An Approximate Bayesian Computation approach was used to model the infection dynamics incorporating the known host ecology. The results demonstrate that EBLV-2 is endemic in the study population, and suggest that mixing between roosts during seasonal swarming events is necessary to maintain EBLV-2 in the population. These findings contribute to understanding how bat viruses can persist despite low prevalence of infection, and why infection is constrained to certain bat species in multispecies roosts and ecosystems. Bats have been implicated as reservoirs for multiple viral, bacterial and protozoal pathogens of human and animal health importance, including Ebola virus, Bartonella spp., and rabies virus 1,2. Aspects of the ecology and demography of bats such as forming high-density aggregations, and flight permitting long-distance movement, may play a role in this ability to maintain a variety of pathogens 2. Mechanisms of pathogen persistence at the population level are often poorly understood, particularly when infection elicits a long lasting protective immune response 3. Rabies virus is one of a growing number of recognised lyssavirus species that are all capable of causing fatal encephalitis 4. The majority of these lyssaviruses are associated with bats 5. Although the full public and animal

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Seroprevalence Dynamics of European Bat Lyssavirus Type 1 in a Multispecies Bat Colony

Cited by 23 publications

References 31 publications

Widespread infection with hemotropic mycoplasmas in bats in Spain, including a hemoplasma closely related to “Candidatus Mycoplasma hemohominis”

Widespread infection with hemotropic mycoplasmas in bats in Spain, including a hemoplasma closely related to “Candidatus Mycoplasma hemohominis”

The persistent prevalence and evolution of cross-family recombinant coronavirus GCCDC1 among a bat population: a two-year follow-up

Between roost contact is essential for maintenance of European bat lyssavirus type-2 in Myotis daubentonii bat reservoir: ‘The Swarming Hypothesis’

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