The persistent prevalence and evolution of cross-family recombinant coronavirus GCCDC1 among a bat population: a two-year follow-up

Obameso, Joseph O.; Li, Hong; Jia, Hao; Han, Min; Zhu, Shuya; Huang, Chao‐Feng; Zhao, Yuhui; Zhao, Min; Bai, Yu; Yuan, Fei; Zhao, Hongqun; Xia, Peng; Xu, Wen; Tan, Wenjie; Zhao, Yang; Yuen, Kwok‐Yung; Liu, William J.; Lü, Lin; Gao, George F.

doi:10.1007/s11427-017-9263-6

Cited by 25 publications

(20 citation statements)

References 19 publications

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“…Different to the genetically diverged HKU9-CoV, this virus is highly conserved (Figure 2). BtEoCoV-GCCDC1 has only been found in south Yunnan Province so far [54,55]. In addition, there are other bat CoVs that have been identified in China: Rhinolophus ferrumequinum α-CoV HuB-2013 [8], Myotis ricketti α-CoV Sax-2011 [8,37], Nyctalus velutinus α-CoV SC-2013 [8], Scotophilus bat CoV 512 [37], Hipposideros bat β-CoV Zhejiang2013, and a Murina leucogaster bat CoV, which has been described as the evolutionary ancestor of PEDV [37].…”

Section: Other Bat Covs In Chinamentioning

confidence: 99%

Bat Coronaviruses in China

Fan

Zhao

et al. 2019

Viruses

576

496

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During the past two decades, three zoonotic coronaviruses have been identified as the cause of large-scale disease outbreaks–Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Swine Acute Diarrhea Syndrome (SADS). SARS and MERS emerged in 2003 and 2012, respectively, and caused a worldwide pandemic that claimed thousands of human lives, while SADS struck the swine industry in 2017. They have common characteristics, such as they are all highly pathogenic to humans or livestock, their agents originated from bats, and two of them originated in China. Thus, it is highly likely that future SARS- or MERS-like coronavirus outbreaks will originate from bats, and there is an increased probability that this will occur in China. Therefore, the investigation of bat coronaviruses becomes an urgent issue for the detection of early warning signs, which in turn minimizes the impact of such future outbreaks in China. The purpose of the review is to summarize the current knowledge on viral diversity, reservoir hosts, and the geographical distributions of bat coronaviruses in China, and eventually we aim to predict virus hotspots and their cross-species transmission potential.

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Section: Other Bat Covs In Chinamentioning

confidence: 99%

Bat Coronaviruses in China

Fan

Zhao

et al. 2019

Viruses

576

496

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“…In etiologic studies with convincing evidence, a series of such fatal diseases in humans have been confirmed or hypothesized to be caused by bat-borne viruses such as Hendra virus (HeV), Ebola virus (EBOV), Marburg virus, and coronaviruses, including severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) [4–10]. Similarly, fetal diseases in livestock have also been associated with emerging viruses of bat origin, such as the fatal disease outbreak of pigs in China, which was found to be caused by a novel coronavirus, swine acute diarrhea syndrome coronavirus (SADS-CoV), from bats [11,12]. Furthermore, it was shown that influenza-like viruses, termed H17N10 and H18N11 circulating among bats in Central America, may act as an ancient influenza reservoir [13,14].…”

Section: Introductionmentioning

confidence: 99%

Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats

et al. 2019

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Bats harbor many zoonotic viruses, including highly pathogenic viruses of humans and other mammals, but they are typically asymptomatic in bats. To further understand the antiviral immunity of bats, we screened and identified a series of bat major histocompatibility complex (MHC) I Ptal-N*01:01–binding peptides derived from four different bat-borne viruses, i.e., Hendra virus (HeV), Ebola virus (EBOV), Middle East respiratory syndrome coronavirus (MERS-CoV), and H17N10 influenza-like virus. The structures of Ptal-N*01:01 display unusual peptide presentation features in that the bat-specific 3–amino acid (aa) insertion enables the tight “surface anchoring” of the P1-Asp in pocket A of bat MHC I. As the classical primary anchoring positions, the B and F pockets of Ptal-N*01:01 also show unconventional conformations, which contribute to unusual peptide motifs and distinct peptide presentation. Notably, the features of bat MHC I may be shared by MHC I from various marsupials. Our study sheds light on bat adaptive immunity and may benefit future vaccine development against bat-borne viruses of high impact on humans.

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“…While exact ecological conditions where genetic exchanges between different pathogens and their evolution took place is often difficult to trace, but as described earlier, the possibility of these changes can increase proportionally with the time spend together inside a tolerant host. For example, longitudinal observation of one population of R. leschenaultii bats for two years found recombinants of RdRp (RNA dependent RNA polymerase) and p10 genes in Ro-BatCoV GCCDC1 within as early as five months since the initial surveillance began (Obameso et al, 2017).…”

Section: Role Of Tolerance In Spillover and New Infectionsmentioning

confidence: 99%

Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm

Seal¹,

Dharmarajan²,

Khan³

2021

Preprint

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Researchers worldwide are repeatedly warning us against future zoonotic diseases resulting from mankind’s insurgence into natural ecosystems. The same zoonotic pathogens that cause severe infections in a human host fail to produce any disease outcome in their natural hosts. What precise features of the immune system enable natural reservoirs to carry these pathogens so efficiently? To understand these effects, we analyse the evolutionary basis of pathogen tolerance in reservoir hosts, while drawing implications from their diverse physiological and life-history traits, and ecological contexts of host-pathogen interactions. Long-term co-evolution might allow reservoir hosts to modulate immunity and evolve tolerance to zoonotic pathogens, increasing their circulation and infectious period. Such processes can also create a genetically diverse pathogen pool by allowing more mutations and genetic exchanges between circulating strains, thereby harbouring rare alive-on-arrival variants with extended infectivity to new hosts (i.e., spillover). Finally, we end by underscoring the indispensability of a large multi-disciplinary empirical framework to explore the proposed link between evolved tolerance, pathogen prevalence and spillover in the wild.

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The persistent prevalence and evolution of cross-family recombinant coronavirus GCCDC1 among a bat population: a two-year follow-up

Cited by 25 publications

References 19 publications

Bat Coronaviruses in China

Bat Coronaviruses in China

Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats

Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm

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