Seroprevalence and serum profile of cytomegalovirus infection among patients with hematologic disorders in Bahia State, Brazil

Abstract

Human cytomegalovirus (CMV) is a ubiquitous herpesvirus with from 30% to 100% of the general population exhibiting prior exposure by serology. This cross-sectional study evaluated the serological profile of anti-CMV antibodies and two acute-phase reaction proteins in Haematologic Disorder Patients (HDPs) from Bahia State, Brazil. Immuno-chemiluminescence assays were performed to detect anti-CMV IgM and IgG antibodies. Serological levels of High Sensitivity C-Reactive Protein (CRPH) and Alpha-1-Acid Glycoprotein (AAG) were measured using immunonephelometry. A total of 470 HDPs were enrolled, 238 (50.6%) males and 232 (49.4%) females. The overall seroprevalence of CMV was 89.4%, directly proportional to age and to the amount of blood units transfused. There was no difference between seroprevalence rates according to gender (P = 0.12). Four HDPs (0.9%) were seropositives for anti-CMV IgM, only one could be characterized as recent acute infection. The most CMV seropositive HDPs had anti-CMV IgG in low titers. There was a tendency for females to have higher anti-CMV IgG titers than men (P < 0.05). CRPH levels were different among HDPs CMV negative and positive groups (P < 0.001). There was no difference in the AAG levels between groups (P = 0.15). The high CMV seroprevalence found underscores the importance of using strategies to provide "CMV safe" blood to HDPs who are at high risk of developing severe CMV infection. CRPH can be used as a biomarker associated with CMV seropositivity; however, more efforts are needed to better characterize the clinical profile of active CMV infection in this group of patients.

Seroprevalence of cytomegalovirus and its coinfection with Epstein-Barr virus in adult residents from Manaus: a population-based study

“…Another study carried out in Salvador city from 2008 to 2010 suggested that there is no significant difference between the sexes with regard to prevalence of cytomegalovirus infections among patients with hematologic disorders. The study reported a significant association in patients aged >58 years 13 .…”

High seropositivity of IgG and IgM antibodies against cytomegalovirus (CMV) among HIV-1 seropositive patients in Ilorin, Nigeria

“…There was significant difference (X2= 1.412, p-value=0.000) in the level of anti-CMV IgM and anti-CMV IgG antibodies among the two groups ( Table 2). The CD4 cell counts ranged from 17 -321 cells/ mm 3 . There was significant association (X2= 1.155, p-value=0.0000) between CD4 cells count and seropositivity outcome of HIV-1 seropositive patients tested for anti-CMV IgM and anti-CMV IgG antibodies (Table 2).…”

“…By serology, 30% to 100% of the general population exhibit prior exposure to the virus 3 . The virus often causes asymptomatic infection in healthy persons; when symptomatic, HCMV infection presents with three recognizable clinical syndromes 4 .…”

“…It showed that their CD4 cell counts ranged from 17 -321 cells/mm 3 . Majority, 69(34.5%) had CD4 cell counts which ranged from 201-250 cells/mm3 while the minority had CD4 counts which ranged from 201-250 cells/mm 3 . From Table 2, it can be seen that majority, 8 (13.6 %) out of the 20 CMV IgM sero-positive individuals had CD4 cell counts which ranged from 51-100 cells/mm 3 while 2 (8.3%) had CD4 cell counts of < 50 cells/mm…”

Etiological Detection for Cerebral Parenchymal Opportunistic Infections in AIDS Patients by PCR

“…CMV is also a ubiquitous agent that can cause infection during the course of life at any time [34], [35] . By serology, 30-100% of the general population exhibit prior exposure to the virus [36] . CMV remains latent in the infected host throughout life and rarely reactivates to cause clinical illness except in immunocompromised individuals [37]- [41] .…”