Seroprevalance of toxoplasma, rubella, CMV and HSV infection in pregnant women in central India

Shrivastava, Gunjan; Bhatambare, GS; Patel, Kamlesh

doi:10.4103/2347-9019.142202

Cited by 6 publications

(11 citation statements)

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“…[ 1 ] The prevalence of Rubella infection in pregnant women from the different country were reported as 87% in the USA, 93.3–94% in Saudi Arabia, 95–96% in Turkey, 98% in Spain. [ 5 11 ] In the present study, rubella was prevalent as 1.14% and infant with 1.96% which is comparatively low as reported in previous studies. A study from Chandigarh reported rubella as 2.8% in children, 4.66% in cases having bad obstetric history (BOH) in Nagpur[ 6 7 ] and 5.66% in females of the reproductive age group of Ludhiana.…”

Section: Discussioncontrasting

confidence: 46%

“…[ 1 8 9 ] The incidence of congenital toxoplasmosis varies from country to country and estimated around 1–2 per 1,000 live births in the UK while 1–10 per 10,000 newborns in Europe and other countries. [ 5 9 ] Previous literature had shown seroprevalence of toxoplasma in different countries between 7.7 and 76.7% as as UK 9.1–17.8%, Norway 10.9%, Sweden 14–25.7%, India 45%, Iran 51.8%, France 71% and Brazil 50–76%. [ 5 10 ] Few Indian studies had been reported a seroprevalence of toxoplasma as 14.66% in cases having a bad obstetric history of Nagpur,[ 6 ] 2.73% in reproductive age group females of Ludhiana.…”

Section: Discussionmentioning

confidence: 99%

“…[ 5 9 ] Previous literature had shown seroprevalence of toxoplasma in different countries between 7.7 and 76.7% as as UK 9.1–17.8%, Norway 10.9%, Sweden 14–25.7%, India 45%, Iran 51.8%, France 71% and Brazil 50–76%. [ 5 10 ] Few Indian studies had been reported a seroprevalence of toxoplasma as 14.66% in cases having a bad obstetric history of Nagpur,[ 6 ] 2.73% in reproductive age group females of Ludhiana. [ 3 ] Fortunately, the present study revealed low toxoplasma seroprevalence as 1.38% in whole population while 1.36% in infants.…”

Section: Discussionmentioning

confidence: 99%

“…[ 12 ] Studies reporting seropositivity of CMV in pregnant women are 56.8% in Australia, 84% in Spain, 39–94.7% in the USA and 84.5–95% in Turkey. [ 5 ] The seroprevalence in Indian adult population ranges 80%–90% with some states of India reporting 15.98% CMV IgM in Kashmir and 12.9% in Delhi and 22.03% for CMV IgM in Punjab,[ 12 13 ] 5.33% in cases with BOH in the study of Nagpur,[ 6 ] 12.5% in children of Chandigarh[ 7 ] and 19.91% infertile females of Ludhiana. [ 3 ] The present study revealed CMV prevalence in infants as 7.4% while overall it was 13.63% which is near to previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 ] It is challenging to diagnose TORCH aetiology clinically, therefore diagnosis is usually established by seroconversion in paired sera or by the presence of specific antibody. [ 5 ] The prevalence of these infections varies with the geographical area. [ 6 ] Data for seroprevalence of TORCH agents in north India are very meager.…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Toxoplasma, Rubella, CMV and HSV infection at a teaching hospital: A 7 year study from North India

Dinkar

Singh

2020

J Family Med Prim Care

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Objectives: The present study was aimed to find seroprevalence in different age group population to explore the burden of TORCH (toxoplasma, rubella virus, cytomegalovirus [(CMV] and herpes simplex virus [HSV]) infection in the North Indian Population. Materials and Methods: It is a retrospective study carried out in the Microbiology Department, Institute of Medical Science, Banaras Hindu University (IMS, BHU), a tertiary care centre of North India. The blood samples of the suspected population of either sex or age group from different departments were analysed over a period of 7 years. The samples were tested for TORCH infections by the IgM ELISA kit following the manufactures instruction. Results: Out of total 4044 samples, 1353 (33.46%) cases were seropositive with maximum cases from the obstetrics and gynaecology department 39.46%. The highest seropositivity of TORCH (43.15%) was in the age group 15–25 years followed by 36.33% in the age group 25–35 years. This study revealed an overall male and female ratio of the total positive cases as 0.12 while it was 2.2 for pediatric cases (0–15 years). The overall seroprevalence was contributed as toxoplasma 1.38%, rubella 1.14%, CMV 13.63% and herpes 17.43%. The overall seropositivity (IgM) contributed as toxoplasma gondii with 4%, rubella with 3%, cytomegalovirus with 41% and herpes simplex virus with 52%. The coinfection of HSV with CMV was most abundant with 246 cases. Conclusions: The seropositivity of toxoplasma and rubella were comparatively more in infants while CMV and herpes were more prevalent in adults. Though, the incidence of TORCH has reduced over the past few years. Furthermore, knowing the epidemiology is an important aspect to develop strategies and appropriate implementation for the prevention of infection.

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Section: Discussioncontrasting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Toxoplasma, Rubella, CMV and HSV infection at a teaching hospital: A 7 year study from North India

Dinkar

Singh

2020

J Family Med Prim Care

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The Screening of Rubella Virus, Cytomegalovirus, Hepatitis B Virus, and Toxoplasma gondii Antibodies in Prepregnancy and Reproductive-Age Women in Tabriz, Iran

Nabizadeh

Ghotaslou

Salahi

et al. 2022

Infectious Diseases in Obstetrics and Gynecology

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Objectives. The organisms of Toxoplasma gondii, Rubella virus, Cytomegalovirus, and Herpes simplex virus as an acronym of TORCH are major pathogens in prepregnancy and reproductive-age women. These microorganisms are considered a serious problem and cause 2-3% of all birth defects in the fetus. Our study was aimed at screening the seroprevalence of TORCH antibodies among prepregnancy and reproductive-age women in Tabriz, Iran. Design and Setting. This study was carried out in 2726 prepregnancy and reproductive-age women, who were referred to the laboratory for prenatal TORCH screening. To detect the presence of IgG, IgM antibodies and Hepatitis B surface antigen against these microorganisms were carried out using a chemiluminescence immunoassay analyzer (CLIA). Results. In the current study, the rates of anti-Toxoplasma gondii IgG, anti-Rubella virus IgG, and anti-Cytomegalovirus IgG were found in 722 cases (26.5%), 2579 cases (94.6%0), and 2718 cases (99.7%), respectively. Moreover, the rates of anti-Toxoplasma gondii IgM, anti-Rubella virus IgM, and anti-Cytomegalovirus IgM were discovered in 10 cases (0.4%), 13 cases (0.5%), and 16 cases (0.6%), respectively. The Hepatitis B surface antigen was found in 32 cases (1.2%). The dissemination of positive TORCH in various ages was different ( P < 0.05 ). Conclusions. In our study, the seroprevalence of acute TORCH infections was relatively low. Due to the probability of vertical transmission to the fetus during pregnancy and the unpleasant complication of these pathogens, it is essential to be screened for detection of specific IgG and IgM antibodies in reproductive ages.

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Seroprevalence of TORCH in women with spontaneous abortion and stillbirth, in Asmara, Eritrea

Adgoy¹,

Elfatih²,

Elhadi³

et al. 2020

Popul. Med.

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INTRODUCTION Toxoplasma gondii, others, rubella, cytomegalovirus and herpes simplex (all together denoted as TORCH) are the major causes of bad obstetric history (BOH) and may cause birth defects. Therefore, antenatal screening for antibodies to TORCH infectious agents is an important tool for diagnosis. Thus, the study was conducted to determine the seroprevalence of TORCH among mothers with a loss of pregnancy (abortion) or stillbirth. METHODS A laboratory-based cross-sectional study on the frequency and associated risk factors for the prevalence of TORCH was conducted from 28 February to 31 March 2018. The study included 44 women aged 18-45 years who were admitted at Orotta Maternity National Referral and Teaching Hospital, Asmara, Eritrea, due to loss of pregnancy (abortion) or stillbirth. The study participants were selected by systematic random sampling. From each woman, 3 mL of venous blood was collected in a container with aseptic technique. Immunoglobulin G antibodies against Toxoplasma gondii, rubella, cytomegalovirus and herpes simplex were detected by IgG Combo Rapid Test Cassette (Serum). RESULTS Of the 44 mothers with mean age of 29.3 years (SD=5.6), who were tested by IgG Combo Rapid Test Cassette

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Seroprevalance of toxoplasma, rubella, CMV and HSV infection in pregnant women in central India

Cited by 6 publications

References 0 publications

Seroprevalence of Toxoplasma, Rubella, CMV and HSV infection at a teaching hospital: A 7 year study from North India

Seroprevalence of Toxoplasma, Rubella, CMV and HSV infection at a teaching hospital: A 7 year study from North India

The Screening of Rubella Virus, Cytomegalovirus, Hepatitis B Virus, and Toxoplasma gondii Antibodies in Prepregnancy and Reproductive-Age Women in Tabriz, Iran

Seroprevalence of TORCH in women with spontaneous abortion and stillbirth, in Asmara, Eritrea

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