Seronegative rheumatoid arthritis, rheumatoid factor cross reactive idiotype expression, and hidden rheumatoid factors.

Bonagura, Vincent R.; Wedgwood, Josiah F.; Agostino, Nicodemo; Hatam, Lynda; Mendez, LM Gomez; Jaffe, Israeli A.; Pernis, Benvenuto

doi:10.1136/ard.48.6.488

Cited by 14 publications

(3 citation statements)

References 33 publications

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“…Earlier reports have confirmed that monoclonal and polyclonal RF may share common idiotypes (7,8,(32)(33)(34). Increased expression of the 6B6.6 CRI has been documented in the sera and synovial fluid of the majority of rheumatoid arthritis patients (7,8).…”

Section: Analysis Of Lc1-reactive H Chains Using Antipeptide Antibodimentioning

confidence: 81%

Structural characterization of the second major cross‐reactive idiotype group of human rheumatoid factors. Association with the V_H4 Gene Family

Silverman

Schrohenloher

Accavitti

et al. 1990

Arthritis & Rheumatism

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Rheumatoid factors (RF) are the most common type of functional antibodies among naturally occurring human monoclonal IgM proteins. A large subset of these autoantibodies use structurally homologous light chains of the kIII subgroup, which bear the 6B6.6 cross‐reactive idiotype (CRI). Although antibody binding activity requires both heavy and light chains, information about the heavy chains used by these autoantibodies is limited. To investigate these proteins, the murine monoclonal antibodies, 5–14 and 6–10, were generated by immunization with the heavy chains of the 6B6.6 CRI‐positive RF, COR and LEW. These antiidiotypic antibodies reacted with 8 of 11 autoantibodies that coexpressed the 6B6.6 CRI. All 8 RF had heavy chains from the VH4 gene family, as assessed by reactivity with a VH4‐specific primary sequence‐dependent antibody. The same RF were also identified by the previously described murine monoclonal antiidiotype, LCI. Further experiments revealed that the LCI antibody delineates a subfamily of VH4 heavy chains that is preferentially used in KIII‐6B6.6 CRI‐positive IgM‐RF. The cumulative data suggest that 13–22% of RF express both the KIII‐6B6.6 and VH4‐LC1 CRI. These findings document that RF autoantibody activity requires specific VL‐VH pairing, and that a subset of idiotypically related VH4 heavy chains is commonly expressed in disease‐associated monoclonal IgM‐RF.

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Section: Analysis Of Lc1-reactive H Chains Using Antipeptide Antibodimentioning

confidence: 81%

Structural characterization of the second major cross‐reactive idiotype group of human rheumatoid factors. Association with the V_H4 Gene Family

Silverman

Schrohenloher

Accavitti

et al. 1990

Arthritis & Rheumatism

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“…However, even in 'seronegative' patients according to the above definition, there may be 'hidden' (masked) RF [71,72] or RF of other subclasses [70,[73][74][75][76][77]. With regard to IgG-RF it is of interest that it can selfassociate and thereby form (pathogenic) immune complexes [78, 78a].…”

Section: Clinical and Immunogenetic Associationsmentioning

confidence: 99%

Autoantibodies in rheumatoid arthritis

Smolen¹

1996

Manual of Biological Markers of Disease

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“…CRI have been clearly demonstrated on natural antibodies (Bonagura et al, 1989;Shoenfeld et al, 1987;Zoller and Achtnich, 1991) found in the sera of healthy individuals (Monestier et al, 1986) specific for ssDNA (Ailus and Palosuo, 1995;Gilbert et al, 1995) and elderly erythrocytes (Gershon, 1993) as well as on rheumatoid factor (RF) (Melero et al, 1998). Consequently, idiotopes found on natural antibodies are called natural idiotopes (Radulovic et al, 1997).…”

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confidence: 99%

Expression of Y7 Cross‐Reactive Idiotope on Human IgM Molecules

Dimitrijević

Stojanović

Ćirić

et al. 2004

Immunological Investigations

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In this paper we report data regarding the IgM Y7 cross-reactive idiotope (CRIo) obtained by analysis of: 1) its V-gene subgroup dependance, 2) the frequency of its expression on human monoclonal IgMs and IgM molecules from normal and pathological sera. Furthermore, comparison of epitopic repertoire and nature of binding of human monoclonal IgMs expressing Y7 CRIo was performed to confirm the natural antibody properties of these molecules. IgM isolated from sera of patient DJ (IgM DJ) which expresses the Y7 idiotope has been classified to VH3/VL2 subgroup. From ten IgMs tested only IgM from patient RD (IgM RD) has been shown to express Y7 idiotope. Y7+ human IgMs bound to ssDNA, lactic acid bacteria, mouse laminin, porcine thyroglobulin and mouse IgG. Higher percentage of the expression of Y7 CRIo was detected in the sera of patients suffering from autoimmune diseases such as lupus, rheumatoid arthritis and psoriasis vulgaris as well as in patients suffering from chronic infections of the lower urinary tract. Antigen binding repertoire and properties of Y7+ monoclonal IgM, frequency of Y7 expression on monoclonal IgMs and its concentration in normal and pathological sera indicate the important biological role of this CRIo within the immune system.

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Seronegative rheumatoid arthritis, rheumatoid factor cross reactive idiotype expression, and hidden rheumatoid factors.

Cited by 14 publications

References 33 publications

Structural characterization of the second major cross‐reactive idiotype group of human rheumatoid factors. Association with the V_H4 Gene Family

Structural characterization of the second major cross‐reactive idiotype group of human rheumatoid factors. Association with the V_H4 Gene Family

Autoantibodies in rheumatoid arthritis

Expression of Y7 Cross‐Reactive Idiotope on Human IgM Molecules

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Seronegative rheumatoid arthritis, rheumatoid factor cross reactive idiotype expression, and hidden rheumatoid factors.

Cited by 14 publications

References 33 publications

Structural characterization of the second major cross‐reactive idiotype group of human rheumatoid factors. Association with the VH4 Gene Family

Structural characterization of the second major cross‐reactive idiotype group of human rheumatoid factors. Association with the VH4 Gene Family

Autoantibodies in rheumatoid arthritis

Expression of Y7 Cross‐Reactive Idiotope on Human IgM Molecules

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Product

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Structural characterization of the second major cross‐reactive idiotype group of human rheumatoid factors. Association with the V_H4 Gene Family

Structural characterization of the second major cross‐reactive idiotype group of human rheumatoid factors. Association with the V_H4 Gene Family