Autoantibodies in rheumatoid arthritis

Smolen, Josef S.

doi:10.1007/978-94-011-1670-1_37

Cited by 32 publications

(22 citation statements)

References 92 publications

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“…Elevated serum IgE has been described in SLE and a direct association was found between total IgE and SLE overall or with other disease characteristics after adjusting for demographic characteristics and allergy history as reported by [41]. Regarding the elevation in the levels of RF in SLE group of patients ( Table 2), it was found to be less obvious in SLE group of patients than that in RA group compared to the control group which in accordance with [42]. The elevation in CRP in this group of patients was found to be in contrary to that reported by [28] who declared that SLE failed to elicit major CRP production despite evident inflammation and tissue damage and the reason was not known.…”

Section: Discussionsupporting

confidence: 81%

Efficacy of Oral Antigen Specific Immunotherapy on Desensitization of Some Autoimmune Diseases Associated with Milk Allergy

Atef¹,

Attia²,

Aal³

2013

FNS

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There are several reports on the prevalence and importance of milk allergens in the induction of allergic diseases, whereas its role in the induction of autoimmune disease was rarely studied. So, the present work aimed to study the diagnosis and the efficacy of oral antigen specific immunotherapy (OAIT) on two groups of autoimmune disease patients namely, rheumatic arthritis (RA), group II, and systemic lupus erythematosus (SLE), group III, who has allergens for milk as an effective treatment option. From the assessment of the data obtained and the clinical outcome of RA and SLE patients after food elimination strategy and milk immunotherapy, it was evident that there were significant reductions (P < 0.001) in the levels of total IgE, specific IgE, Rheumatic factor (R.F), C-reactive protein (C.R.P), Anti-nuclear antibodies (ANA) and anti-double stranded DNA antibodies (Anti-ds DNA) compared to pretreated levels. Moreover, the immunotherapy induced "blocking antibodies" by remarkable highly significant increasing in IgG, phagocytic inhibition test (PIT %), Complement component 3(C3), and Complement component 4 (C4) levels. More improvement was noticed in the SLE as a result of the immunotherapy. Conclusion: milk desensitization is a gained interest and a safe valuable effective treatment of autoimmune conditions in Egypt.

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Section: Discussionsupporting

confidence: 81%

Efficacy of Oral Antigen Specific Immunotherapy on Desensitization of Some Autoimmune Diseases Associated with Milk Allergy

Atef¹,

Attia²,

Aal³

2013

FNS

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“…They are found in every immunoglobulin subclass (IgE, IgM, IgA and IgG). IgG RF has a self-binding capacity that can result in the formation of very large immune complexes, which are able to (further) activate the immune system (reviewed in [3]). It is not clear whether RF is directly related to the symptoms of RA, although RF is found significantly more often in cases of aggressive joint inflammation.…”

Section: Autoantibodies Associated With Rfmentioning

confidence: 99%

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Boekel

Vossenaar

Hoogen³

et al. 2002

Arthritis Res

303

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The diagnosis of rheumatoid arthritis (RA) is primarily based on clinical symptoms, so it is often difficult to diagnose RA in very early stages of the disease. A disease-specific autoantibody that could be used as a serological marker would therefore be very useful. Most autoimmune diseases are characterized by a polyclonal B-cell response targeting multiple autoantigens. These immune responses are often not specific for a single disease. In this review, the most important autoantibody/autoantigen systems associated with RA are described and their utility as a diagnostic and prognostic tool, including their specificity, sensitivity and practical application, is discussed. We conclude that, at present, the antibody response directed to citrullinated antigens has the most valuable diagnostic and prognostic potential for RA.

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“…Hier sei insbesondere auf die Rolle von Anti-DNA-Antikörpern bei der Lupus Nephritis oder der gegen Phospholipide (insbesondere Cardiolipin) gerichteten Antikörper beim Anti-Phospholipid-Syndrom hingewiesen. Beim pathologischen Geschehen der RA erscheint eine Beteiligung von RFImmunkomplexen als wahrscheinlich, während die Rolle anderer Autoantikörper unbekannt ist, auch wenn manche von ihnen in Tiermodellen eine destruktive Arthritis induzieren können (35,36). Dies gilt in noch höherem Maße für autoreaktive T-Zellen, denen bei Organ-spezifischen Autoimmunerkrankungen entscheidende pathogenetische Bedeutung zukommt.…”

Section: Abschließende Bemerkungenunclassified

Neue Autoantikörper in der Diagnostik der rheumatoiden Arthritis

Steiner¹,

Smolen²

2002

Zeitschrift f�r Rheumatologie

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The diagnosis of rheumatoid arthritis has been hampered by the lack of a truly disease-specific serologic marker. Thus, despite its moderate specificity rheumatoid factor (RF) is still the only established marker antibody for RA and among the diagnostic criteria of the American College of Rheumatology the only serologic one. However, in recent years, several newly characterized autoantibodies have been described that may have the potential to become diagnostic indicators for RA. In particular, antibodies to citrullinated targets (anti-keratin or anti-filaggrin antibodies, respectively, antibodies to synthetic citrullinated peptides) appear to be highly specific for RA. Other potentially useful antibodies include anti-RA33 autoantibodies and antibodies to the stress protein BiP which seem to have higher specificity for RA than RF. Apart from being promising diagnostic markers these autoantibodies or the underlying cellular autoimmune reactions, respectively, may also play a role in the pathogenesis of RA.

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Autoantibodies in rheumatoid arthritis

Cited by 32 publications

References 92 publications

Efficacy of Oral Antigen Specific Immunotherapy on Desensitization of Some Autoimmune Diseases Associated with Milk Allergy

Efficacy of Oral Antigen Specific Immunotherapy on Desensitization of Some Autoimmune Diseases Associated with Milk Allergy

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Neue Autoantikörper in der Diagnostik der rheumatoiden Arthritis

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