Seronegative rheumatoid arthritis: Pathogenetic and therapeutic aspects

Pratt, Arthur G.; Isaacs, John D.

doi:10.1016/j.berh.2014.10.016

Cited by 64 publications

(51 citation statements)

References 84 publications

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“…Higher levels mean more joint destruction, extra-articular diseases and poor quality of life. (22) Our results are similar with a study by Wolfe and colleagues who reported that higher ESR, CRP and RF levels were all predictors of anemia in patients with RA. (23) Almost all patients diagnosed with RA in our clinics were started on DMARDs as a first line treatment and DMARD monotherapy especially with MTX is the regimen chosen by almost all our rheumatologists to initiate treatment.…”

Section: Discussionsupporting

confidence: 92%

Clinical and Laboratory Parameters Associated with Anemia in Rheumatoid Arthritis Patients

Nuseir¹,

Al-Hzymeh²,

Jaradat³

2018

JRMS

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Section: Discussionsupporting

confidence: 92%

Clinical and Laboratory Parameters Associated with Anemia in Rheumatoid Arthritis Patients

Nuseir¹,

Al-Hzymeh²,

Jaradat³

2018

JRMS

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“…We used type II collagen immunization of Sprague Dawley rats to establish a model of rheumatoid arthritis. The clinical manifestation, pathological and immunological changes found in this model are similar to those in humans [22–24]. …”

Section: Discussionsupporting

confidence: 70%

Early detection of rheumatoid arthritis in rats and humans with 99mTc-3PRGD2 scintigraphy: imaging synovial neoangiogenesis

Zhang

Wang

et al. 2016

Oncotarget

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Objectives: To validate 99mTc-labeled arginylglycylaspartic acid (99mTc-3PRGD2) scintigraphy as a means to image synovial neoangiogenesis in joints afflicted by rheumatoid arthritis and to investigate its potential in the early detection and management of rheumatoid arthritis.Methods: Rheumatoid arthritis and osteoarthritis were generated in Sprague Dawley rats by type II collagen immunization and papain injection, respectively. Rats were imaged with 99mTc-3PRGD2 and 99mTc- methyl diphosphonate (99mTc MDP). X-ray images were also obtained and assessed by a radiologist. Immunohistochemistry of αvβ3 and CD31confirmed the onset of synovial neoangiogenesis. The effect of bevacizumab on rheumatoid arthritis was followed with 99mTc-3PRGD2 scintigraphy. A patient with rheumatoid arthritis and a healthy volunteer were scanned with 99mTc-3PRGD2.Results: Two weeks after immunization, a significant increase in 99mTc-3PRGD2 was observed in the joints of the rheumatoid arthritis model though uptake in osteoarthritis model and untreated controls was low. 99mTc-MDP whole body scans failed to distinguish early rheumatoid arthritis joints from healthy controls. The expression of αvβ3 and CD31was significantly higher in the joints of rheumatoid arthritis rats compared to normal controls. In serial 99mTc-3PRGD2 scintigraphy studies, 99mTc-3PRGD2 uptake increased in parallel with disease progression. Bevacizumab anti-angiogenetic therapy both improved the symptoms of the rheumatoid arthritis rats and significantly decreased 99mTc-3PRGD2 uptake. Significantly higher 99mTc-3PRGD2 accumulation was also observed in rheumatoid arthritis joints in the patient.Conclusions: Our findings indicate that 99mTc-3PRGD2 scintigraphy could detect early rheumatoid arthritis by imaging the associated synovial neoangiogenesis, and may be useful in disease management.

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“…In the presence of periodontal disease, the potential role of pathogenic bacteria has been reported to affect rheumatoid arthritis because pathogenic bacteria infiltrate the blood and are activated at the onset of rheumatoid arthritis . P. gingivalis , the causative agent of periodontal disease, was found to be the most potent strain suspected of being associated with rheumatoid arthritis . In addition, impaired hand function of patients with rheumatoid arthritis can lead to limitations with toothbrushing, which can have a limited impact on oral health behavior and lead to periodontal disease …”

Section: Introductionmentioning

confidence: 99%

“…13 P. gingivalis, the causative agent of periodontal disease, was found to be the most potent strain suspected of being associated with rheumatoid arthritis. 14,15 In addition, impaired hand function of patients with rheumatoid arthritis can lead to limitations with toothbrushing, which can have a limited impact on oral health behavior and lead to periodontal disease. 16 In a study using data from the US National Health and Nutrition Examination Survey (NHANES), subjects with rheumatoid arthritis were more likely to have periodontitis than subjects without rheumatoid arthritis.…”

Section: Introductionmentioning

confidence: 99%

Relationship between rheumatoid arthritis and periodontal disease in Korean adults: Data from the Sixth Korea National Health and Nutrition Examination Survey, 2013 to 2015

Jung

Choi

Lee

2018

Journal of Periodontology

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Background This study aims to investigate the relationship between rheumatoid arthritis and periodontal disease using data from the Sixth Korea National Health and Nutrition Examination Survey (KNHANES, 2013 to 2015). Methods Of 22,948 KNHANES participants, 14,264 who were aged ≥19 years and responded to questions pertaining to periodontal disease and rheumatoid arthritis were analyzed. Periodontal status was measured using the Community Periodontal Index. The authors used a complex sampling analysis by applying an individual sampling weighting to maintain the rolling survey sampling method. To determine the prevalence of rheumatoid arthritis and periodontal disease, a Chi‐squared test was performed. Logistic regression analysis was performed after controlling for selected variables to determine relevance. Results The prevalence of rheumatoid arthritis in patients with periodontal disease was 1.6%, which was higher than in individuals without periodontal disease (1.5%). The prevalence of periodontal disease in individuals with rheumatoid arthritis was 28.4%, which was higher than in subjects without rheumatoid arthritis (27.9%). The risk for periodontal disease was 1.64 times higher in individuals with rheumatoid arthritis than in those without rheumatoid arthritis. Regardless of age or sex, the risk for periodontal disease was 1.97 times higher in the presence of rheumatoid arthritis. However, other logistic regression analysis models, when adjusted for socioeconomic‐, health‐, and oral health‐related factors, did not yield statistically significant findings. Conclusions The study results suggest a possible relationship between rheumatoid arthritis and periodontal disease. Further large cohort studies investigating causal relationships between rheumatoid arthritis and periodontal disease are needed.

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Seronegative rheumatoid arthritis: Pathogenetic and therapeutic aspects

Cited by 64 publications

References 84 publications

Clinical and Laboratory Parameters Associated with Anemia in Rheumatoid Arthritis Patients

Clinical and Laboratory Parameters Associated with Anemia in Rheumatoid Arthritis Patients

Early detection of rheumatoid arthritis in rats and humans with 99mTc-3PRGD2 scintigraphy: imaging synovial neoangiogenesis

Relationship between rheumatoid arthritis and periodontal disease in Korean adults: Data from the Sixth Korea National Health and Nutrition Examination Survey, 2013 to 2015

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