Serological survey ofLeptospira interrogans,Toxoplasma gondiiandTrypanosoma cruziin free roaming domestic dogs and cats from a marginated rural area of Yucatan Mexico

Ortega-Pacheco, Antonio; Guzmán-Marín, Eugenia; Acosta-Viana, Karla Y.; Vado-Solís, Ignacio; Jiménez-Delgadillo, Bertha; Cárdenas-Marrufo, María; Pérez-Osorio, Carlos; Puerto-Solís, Marilyn; Jiménez‐Coello, Matilde

doi:10.1002/vms3.55

Cited by 12 publications

(6 citation statements)

References 26 publications

(34 reference statements)

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“…In a study conducted in three Mexican cities (Mérida, Umán and Tulum) in Yucatán, 7.8% of 95 cats were positive by ELISA and Western blot, using excreted superoxide dismutase as antigen [122]. Interestingly, no infection was observed in other studies conducted in distinct parts of Mexico [32,38,39].…”

Section: Trypanosoma Cruzi Infection and CD In Catsmentioning

confidence: 94%

“…In Mexico, a study conducted in 2010 reported a prevalence of 34% [31], while another study carried out in 2017 detected a prevalence of 4.4% [32]. Other studies conducted in Mexico have reported different prevalence values [33][34][35][36][37][38][39][40][41][42][43]. Recently, anti-T. cruzi antibodies were detected in 50% (17/34) of dogs from two rural settlements in the Sierra de Los Tuxtlas, Veracruz, Mexico [44].…”

Section: Trypanosoma Cruzi Infection and CD In Dogsmentioning

confidence: 99%

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Technological advances in the serological diagnosis of Chagas disease in dogs and cats: a systematic review

et al. 2022

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Background Chagas disease (CD) is caused by Trypanosoma cruzi, which is transmitted mainly through the feces/urine of infected triatomine bugs. The acute phase lasts 2–3 months and is characterized by high parasitemia and nonspecific symptoms, whereas the lifelong chronic phase features symptoms affecting the heart and/or digestive tract occurring in 30–40% of infected individuals. As in humans, cardiac abnormalities are observed in T. cruzi-infected dogs and cats. We reviewed the technological advances in the serological diagnosis of CD in dogs and cats. Methods A review of the published literature during the last 54 years (1968–2022) on the epidemiology, clinical features, diagnosis, treatment and prevention of CD in dogs and cats was conducted. Results Using predefined eligibility criteria for a search of the published literature, we retrieved and screened 436 publications. Of these, 84 original studies were considered for inclusion in this review. Dogs and cats are considered as sentinels, potentially indicating an active T. cruzi transmission and thus the risk for human infection. Although dogs and cats are reputed to be important for maintaining the T. cruzi domestic transmission cycle, there are no commercial tests to detect past or active infections in these animals. Most published research on CD in dogs and cats have used in-house serological tests prepared with native and/or full-length recombinant antigens, resulting in variable diagnostic performance. In recent years, chimeric antigens have been used to improve the diagnosis of chronic CD in humans with encouraging results. Some of them have high performance values (> 95%) and extremely low cross-reactivity rates for Leishmania spp., especially the antigens IBMP-8.1 to IBMP-8.4. The diagnostic performance of IBMP antigens was also investigated in dogs, showing high diagnostic performance with negligible cross-reactivity with anti-Leishmania infantum antibodies. Conclusions The development of a commercial immunodiagnostic tool to identify past or active T. cruzi infections in dogs and cats is urgently needed. The use of chimeric recombinant T. cruzi antigens may help to fill this gap and is discussed in this review. Graphical Abstract

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Section: Trypanosoma Cruzi Infection and CD In Catsmentioning

confidence: 94%

Section: Trypanosoma Cruzi Infection and CD In Dogsmentioning

confidence: 99%

Technological advances in the serological diagnosis of Chagas disease in dogs and cats: a systematic review

et al. 2022

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“…Serologic diagnosis of Leptospira spp. : Antibodies were approached using the microscopic agglutination test (MAT) [ 11 ]. MAT is considered the gold standard of reference for the diagnosis of leptospirosis and was performed using live antigens at the laboratory of the Faculty of Medicine of the Autonomous University of Yucatan under the World Health Organization’s protocols.…”

Section: Case Presentationmentioning

confidence: 99%

“…During the rainy season, water is not easily absorbed by the rough soil, generating puddles where animals find drinking sources. Leptospirosis prevalence in humans in the region was reported to amount to 14.1% in 1984 and 14.2% in 2002; it was more prevalent in rural areas than in urban ones, with 74.3% of the reported cases occurring during the rainy season [ 11 ]. In a seroprevalence study conducted on humans in 2018 in the same area, seropositivity of 35% was reported [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Manifestations in a Fatal Case of Probable Rickettsia and Leptospira Coinfection in Yucatan, Mexico

et al. 2021

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Clinical or serological coinfections of Rickettsia and Leptospira are uncommon but should be included in differential diagnosis when poor sanitation and cohabitation with infected animals may converge. Rickettsial and leptospiral infections have been continuously increasing throughout the past decade in Yucatan, Mexico. Leptospirosis is a zoonotic disease caused by aerobic spirochetes, while rickettsiosis is an arthropod-borne disease. In 2020, 16% of all rickettsiosis cases and 10% of leptospirosis in the country originated in Yucatan. The objective of the present case report was to document an unusual case of probable coinfection with Rickettsia and Leptospira with emphasis on clinical manifestations and the epidemiological context that may orient future multidisciplinary measures. Here, we presented the case of a 12-year-old female whose mother had recently recovered from a rickettsial infection. The patient presented with fever and developed unspecific signs and symptoms of infection; however, her condition quickly deteriorated with gastrointestinal, hepatic, renal, and neurological dysfunction. After discounting rabies and identifying infection with Rickettsia and Leptospira, antibiotic treatment was indicated, but it was too late to prevent death. Simultaneous infections of Rickettsia and Leptospira may be considered in endemic regions when environmental, epidemiological, and clinical conditions converge.

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“…En la búsqueda de mejores y más rápidas pruebas diagnósticas para la leptospirosis, se diseñó una prueba de diagnóstico rápida y confiable de ELISA la cual ofrece un pronto diagnóstico para zonas remotas con escaso acceso a laboratorios especializados (Abdoel et al, 2011). Estudios epidemiológicos más recientes en zonas rurales de alta marginación de Yucatán revelan seroprevalencias de 45.2 % y 15.2 % en perros y gatos, respectivamente, incluyendo los serovares Canicola, Autralis y Bratislava fueron las de mayor circulación (Ortega-Pacheco et al, 2017). Un posterior estudio epidemiológico en gatos de la ciudad de Mérida, Yucatán, demostró una seroprevalencia del 17% en los cuales la serovariedad Australis fue la más predominante (54.3 %) seguida de la Pyrogenes (15.3 %) y Gryppotyphosa (13.0 %) (Ortega-Pacheco et al, 2020).…”

Section: Introductionunclassified

Principales Aportaciones Científicas De La FMVZ-Uady en La Epidemiología La Leptospirosis, Toxoplasmosis, Tripanosomiasis Americana, Y Dirofilariosis en Animales Domésticos Y Sinantrópicos

Ortega-Pacheco

Aguilar-Caballero²,

Torres-Acosta³

et al. 2021

Trop Subtrop Agroecosyst

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Background. In tropical and subtropical regions there are ideal conditions for the maintenance and proliferation of leptospirosis, toxoplasmosis, American trypanosomiasis, and heartworm disease, which affect the welfare and health of domestic and synanthropic animals and can cause zoonoses. Objective. To identify the main epidemiological findings of potentially zoonotic diseases such as leptospirosis, toxoplasmosis, American trypanosomiasis, and heartworm disease in domestic animals, synanthropics, and humans in the Yucatan Peninsula. Methodology. The compilation of scientific articles from the studies carried out by the academic body of Animal Health in the first 50 years of the Faculty of Veterinary Medicine and Animal Science of the Autonomous University of Yucatan was carried out. The review focused on four infectious agents with zoonotic potential (Leptospira spp, Toxoplasma gondii, Trypanosoma cruzi, and Dirofilaria immitis) that affect animals in the Yucatan peninsula. Results. The studies have shown a wide distribution of animals affected by these agents and described various aspects of epidemiology in animals and humans. Implications. Epidemiological monitoring of these agents and the study of their impact on health is essential for decision-making when it comes to implementing official control and prevention measures in both animals and humans. Conclusions. The infectious agents described (bacteria, protozoa and nematode) have a wide distribution in various species of domestic and synanthropic animals of the Yucatan peninsula, and have an impact on the human population in this region of Mexico. The epidemiological conditions described in this region should serve to prevent and control these diseases.

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Serological survey ofLeptospira interrogans,Toxoplasma gondiiandTrypanosoma cruziin free roaming domestic dogs and cats from a marginated rural area of Yucatan Mexico

Cited by 12 publications

References 26 publications

Technological advances in the serological diagnosis of Chagas disease in dogs and cats: a systematic review

Technological advances in the serological diagnosis of Chagas disease in dogs and cats: a systematic review

Clinical Manifestations in a Fatal Case of Probable Rickettsia and Leptospira Coinfection in Yucatan, Mexico

Principales Aportaciones Científicas De La FMVZ-Uady en La Epidemiología La Leptospirosis, Toxoplasmosis, Tripanosomiasis Americana, Y Dirofilariosis en Animales Domésticos Y Sinantrópicos

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