Serological study of antibodies to influenza A viruses among general population in Wuhan city China

Xiong, Chaochao; Sū, Zhèngyuán; Liu, Zhihua; Liu, Qian; Zhao, Lihua; Gao, Zhimin; Chen, Quanjiao; Deng, Fei; Chen, Jianjun

doi:10.1016/j.jcv.2014.06.007

Cited by 8 publications

(7 citation statements)

References 10 publications

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“…Consistent with our hypothesis, we demonstrated a positive association between increasing antibody diversity and heterosubtypic reactivity against AIV antigens. These observations are consistent with previous publications that have found raised antibody titers to AI antigens in the general population 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 . A population-based studies on heterosubtypic immunity of intravenous immunoglobulins (IVIG) from blood donors from Australia, Malaysia and Europe clearly showed binding of heterosubtypic antibodies against H9 and H5, but negligible binding against H7 subtypes by immunoblotting.…”

Section: Discussionsupporting

confidence: 93%

Changes in heterosubtypic antibody responses during the first year of the 2009 A(H1N1) influenza pandemic

Freidl

Ham²,

Boni

et al. 2016

Sci Rep

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Seropositivity to avian influenza (AI) via low-level antibody titers has been reported in the general population and poultry-exposed individuals, raising the question whether these findings reflect true infection with AI or cross-reactivity. Here we investigated serological profiles against human and avian influenza viruses in the general population using a protein microarray platform. We hypothesized that higher antibody diversity across recent H1 and H3 influenza viruses would be associated with heterosubtypic reactivity to older pandemic- and AI viruses. We found significant heterogeneity in antibody profiles. Increased antibody diversity to seasonal influenza viruses was associated with low-level heterosubtypic antibodies to H9 and H7, but not to H5 AI virus. Individuals exposed to the recent 2009 A(H1N1) pandemic showed higher heterosubtypic reactivity. We show that there is a complex interplay between prior exposures to seasonal and recent pandemic influenza viruses and the development of heterosubtypic antibody reactivity to animal influenza viruses.

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Section: Discussionsupporting

confidence: 93%

Changes in heterosubtypic antibody responses during the first year of the 2009 A(H1N1) influenza pandemic

Freidl

Ham²,

Boni

et al. 2016

Sci Rep

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“…The findings of a seroepidemiological study on AI H5, H7 and H9 viruses have been reported by Xiong et al 5 in the urban general population in China. The authors estimated the previous or transient asymptomatic and mild infections of AI viruses in the general population.…”

supporting

confidence: 55%

“…An assumption of <5 per cent antibody prevalence against AI H7N9 virus was made based on the similar studies performed outside India567. The sample size calculations were performed using online OpenEpi software8.…”

mentioning

confidence: 99%

Avian influenza A H7N9 virus infections not evident among high-risk groups in India

Pawar¹,

Tandale²,

Mali³

et al. 2016

Indian J Med Res

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“…By contrast, the H7N9 case count has risen to nearly 80% of the current H5N1 case count in only 2 years. The H7N9 and H5N1 viruses share many similar characteristics, including incubation time [4][5][6], host and human tissue tropism [7][8][9][10][11], treatments [12], antiviral sensitivity [12,13], reservoirs [14][15][16][17], reproductive numbers [18][19][20][21], and low levels of population immunity to both viruses [22][23][24]. There are also some significant differences between the two viruses, including epidemiological risk factors [4,12,25], case-fatality rates [1,3], geography of human cases [3,26], vaccine status [27,28], and the degree of pathogenicity in humans and poultry [9,29].…”

Section: Background and Epidemiologymentioning

confidence: 99%

“…Wild birds, domestic birds (poultry), poultry markets, wet markets [14] Wild birds, domestic birds (poultry) [7,15] Human to human transmission Low to moderate transmissibility; some family clusters reported; no sustained transmission [12,18,19] Low transmissibility; limited human-to-human transmission has been reported [12,21] Population immunity Low or non-existent [22][23][24] Low or non-existent [22,24] COPD, Chronic obstructive pulmonary disease. *As of 11 May 2015.…”

Section: Vaccine Statusmentioning

confidence: 99%

The pandemic potential of avian influenza A(H7N9) virus: a review

2015

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In March 2013 the first cases of human avian influenza A(H7N9) were reported to the World Health Organization. Since that time, over 650 cases have been reported. Infections are associated with considerable morbidity and mortality, particularly within certain demographic groups. This rapid increase in cases over a brief time period is alarming and has raised concerns about the pandemic potential of the H7N9 virus. Three major factors influence the pandemic potential of an influenza virus: (1) its ability to cause human disease, (2) the immunity of the population to the virus, and (3) the transmission potential of the virus. This paper reviews what is currently known about each of these factors with respect to avian influenza A(H7N9). Currently, sustained human-to-human transmission of H7N9 has not been reported; however, population immunity to the virus is considered very low, and the virus has significant ability to cause human disease. Several statistical and geographical modelling studies have estimated and predicted the spread of the H7N9 virus in humans and avian species, and some have identified potential risk factors associated with disease transmission. Additionally, assessment tools have been developed to evaluate the pandemic potential of H7N9 and other influenza viruses. These tools could also hypothetically be used to monitor changes in the pandemic potential of a particular virus over time.

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Serological study of antibodies to influenza A viruses among general population in Wuhan city China

Cited by 8 publications

References 10 publications

Changes in heterosubtypic antibody responses during the first year of the 2009 A(H1N1) influenza pandemic

Changes in heterosubtypic antibody responses during the first year of the 2009 A(H1N1) influenza pandemic

Avian influenza A H7N9 virus infections not evident among high-risk groups in India

The pandemic potential of avian influenza A(H7N9) virus: a review

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