Serological Screening for Celiac Disease in Adult Chinese Patients With Diarrhea Predominant Irritable Bowel Syndrome

Wang, Hongling; Zhou, Guoying; Luo, Linjie; Crusius, J. Bart A.; Yuan, Anlong; Kou, Jiguang; Yang, Guifang; Wang, Min; Wu, Jing; Blomberg, B. Mary E. von; Morré, Servaas A.; Peña, Amado Salvador; Xia, Bing

doi:10.1097/md.0000000000001779

Cited by 34 publications

(38 citation statements)

References 44 publications

(39 reference statements)

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“…(16,17,26,49,56,57,63,69) Overall, there were 49 (2.4%) individuals meeting criteria for IBS with duodenal biopsy findings consistent with CD, compared with 16 (0.6%) subjects who did not meet criteria for IBS, with an OR of 4.48 (95% CI 2.33 to 8.60) ( Figure 4 and Table 2), and no significant heterogeneity between studies (I 2 = 0%, P = 0.45). There were too few studies to assess for publication bias.…”

Section: Yield Of Duodenal Biopsy After Positive Celiac Serologymentioning

confidence: 99%

“…Twelve of these 32 studies also reported prevalence of a positive EMA and/or tTG in non-IBS subjects (16,17,25,26,41,45,56,57,60,63,65,69). Among 2677 cases with IBStype symptoms, 57 (2.1%) had a positive EMA and/or tTG, compared with 49 (0.8%) of 5931 controls.…”

Section: Yield Of Ema And/or Ttg Testing In Suspected Ibsmentioning

confidence: 99%

“…The OR for a positive EMA and/or tTG subjects with suspected IBS, compared with healthy controls was 1.01 (95% CI 0.20 to 5.09) ( Figure 3 and Table 2). The remaining eight studies were conducted in secondary or tertiary care (16,26,41,45,56,57,63,69). The OR for a positive EMA and/or tTG in 2020 individuals meeting criteria for IBS, compared with 1964 controls, was 4.32 (95% CI 2.17 to 8.58) ( Figure 3 and Table 2).…”

Section: Yield Of Ema And/or Ttg Testing In Suspected Ibsmentioning

confidence: 99%

See 2 more Smart Citations

Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis

Irvine

Chey

Ford

2017

American Journal of Gastroenterology

131

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Section: Yield Of Duodenal Biopsy After Positive Celiac Serologymentioning

confidence: 99%

Section: Yield Of Ema And/or Ttg Testing In Suspected Ibsmentioning

confidence: 99%

Section: Yield Of Ema And/or Ttg Testing In Suspected Ibsmentioning

confidence: 99%

See 1 more Smart Citation

Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis

Irvine

Chey

Ford

2017

American Journal of Gastroenterology

131

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“…Currently, it is well known that the Amerindian people expressing HLA-DQ8 haplotype alone or in combination with an HLA-DQ2 allele could suffer celiac disease [8,9]. More recently, Wang et al [10] found that Asian individuals with HLA-DQ9.3 are also prone to celiac disease.…”

Section: The Intricate Spectrum Of Gluten-/wheat-related Diseasesmentioning

confidence: 99%

Are Gluten-Free Foods Just for Patients with a Gluten-Related Disease?

Barca¹,

Mejía-León²

2017

Celiac Disease and Non-Celiac Gluten Sensitivity

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Gluten, the set of wheat proteins that gives properties for food processing, is the cause of celiac disease (CD), and patients require a gluten-free diet lifelong. There are other bad-called gluten-related diseases as non-celiac gluten sensitivity and irritable bowel syndrome, for which triggering compounds are unknown, while wheat allergies and carbohydrate intolerances are associated with other wheat proteins and fructans, respectively. The boundaries of each disease are not clear, inducing confusion for diagnosis and dilemma about the right diet. Nowadays, the people who are currently in a gluten-free diet exceed several times the expected number of those requiring dietary gluten exclusion. It is because people consider themselves as afected and dangerously decide to selfdiagnose as gluten intolerant and adopt a gluten-free diet. The alternative compounds used in gluten-free foods to obtain the technological properties given by gluten could induce problems in some disease conditions or lead to undernutrition especially in children and adolescents. It is because some gluten-free foodstufs are limited in vitamins and minerals and contain more fat and sodium than their conventional wheat analogues. Therefore, gluten-free is not a good option for persons without diagnosis; it should be understood as a therapy, prescribed and followed by specialists.

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“…Based on the increased exposure to gluten and the predisposing HLA allele frequencies in the Chinese population, CD might be more common in China than currently reported (10). Moreover, previous studies about screening CD in at-risk groups in China found that the prevalence of CD was 6.5%-11.9% in patients with chronic diarrhea and 1.77%-8.2% in patients with diarrhea-predominant irritable bowel syndrome (11)(12)(13)(14). However, there are no related data from China on the occurrence of CD in patients with elevated transaminases.…”

Section: Introductionmentioning

confidence: 96%

Serologic testing for celiac disease in young people with elevated transaminases

Yuan¹,

Gao²,

Yao

et al. 2015

Turk J Med Sci

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Background/aim: A cryptogenic elevation of transaminases is the most common hepatic manifestation in celiac disease (CD). In adult patients and pediatric patients with cryptogenic hypertransaminasemia, the prevalence of CD was 4% and 12%, respectively. However, there are no related data from China in this regard. We aimed to investigate the status of CD in young Chinese patients with elevated transaminases.Materials and methods: A total of 125 patients with elevated transaminases and 125 healthy individuals as controls with matched age and sex were involved in the study. Serum markers of hepatitis B were determined in patients with elevated transaminases. All subjects were screened for CD by testing serum IgA antitissue transglutaminase antibodies (anti-tTG IgA), and total serum IgA was determined in order to rule out IgA deficiency.Results: None of the subjects were seropositive to IgA anti-tTG antibodies. No association between CD and elevated transaminases was found. Hepatitis B viral infections were one of the main causes of raised transaminases. Conclusion:Before the exclusion of every known cause of raised transaminase levels, routine serological screening for CD should not be recommended for patients who only present elevated transaminases.

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Serological Screening for Celiac Disease in Adult Chinese Patients With Diarrhea Predominant Irritable Bowel Syndrome

Abstract: Supplemental Digital Content is available in the text

Cited by 34 publications

References 44 publications

Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis

Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis

Are Gluten-Free Foods Just for Patients with a Gluten-Related Disease?

Serologic testing for celiac disease in young people with elevated transaminases

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