Serological response of commercial dairy cattle to inactivated foot-and-mouth disease vaccine (type-O &amp; A) in Nigeria

Lazarus, ‪David Dazhia; Wungak, Y.S.; Adah, Mohammed I.; Ibu, J. O.; Abenga, J. N.; Ekong, Pius S.; Ularamu, Hussaini

doi:10.3329/ajmbr.v1i2.25606

Cited by 4 publications

(4 citation statements)

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“…This study has demonstrated that FMDV remains endemic among pastoral and sedentary husbandry systems within the study areas with multiple serotypes widely distributed. The four FMDV serotypes detected in the course of these studies along with previous reports in Nigeria establish the facts that these are the most prevalent serotypes circulating among cattle in the country [ 7 , 9 , 18 , 19 ]. However, to the best of our knowledge, this study has provided the first comprehensive spatial distribution of FMDV serotypes in the North-Central Nigeria, indicating only quadravalent vaccine, including the local isolates containing serotypes A, O, SAT 1, and SAT 2, should be used for vaccination campaign against FMD in Nigeria.…”

Section: Discussionsupporting

confidence: 76%

Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria

et al. 2017

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Aim:This study aimed to determine the foot-and-mouth disease virus (FMDV) serotypes circulating, the prevalence of FMDV serotypes, and the spatial distribution of FMDV among sedentary and pastoral cattle herds in the North-Central Nigeria.Materials and Methods:A cross-sectional study was undertaken, during which a total of 155 sera that tested positive for foot-and-mouth disease (FMD) 3ABC non-structural protein antibodies were selected and screened for FMD structural protein serotypes, A, O, SAT 1, and SAT 2 using a solid-phase competitive enzyme-linked immunosorbent assay (ELISA). Epithelial tissue specimens were collected during outbreak investigations which were tested for FMD using an antigen capture ELISA for serotype A, O, SAT 1, and SAT 2.Results:An overall serotype-specific prevalence of 79.35 (95% confidence interval [CI]: 72.4-85.18) was recorded for serotype O, 65.2% (95% CI: 57.41-72.3) for serotype A, 52.9% (95% CI: 45.03-60.67) for SAT 2, and 33.55% (95% CI: 26.45-41.26) for SAT 1. Evidence of exposure to multiple FMDV serotypes showed that 12.26% of the sera samples had antibodies against four serotypes circulating, 30.97% had antibodies against three serotypes circulating, 22.58% had antibodies against two serotypes, and 17% showed exposure to only one serotype. Clinical specimens (epithelial tissue) collected during outbreak investigations showed that serotype O has the highest proportion of 50% with serotype A - 25%; SAT 2 - 20.8%; and SAT 1 - 4.1%.Conclusion:The study detected diffuse and co-circulation of serotypes A, O, SAT 1, and SAT 2 within the study area, and hence the need for the appropriately matched multivalent vaccine is strongly advocated for FMD control in Nigeria.

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Section: Discussionsupporting

confidence: 76%

Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria

et al. 2017

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“…FMD was previously eliminated in certain developed nations such as the USA, Canada, Australia, England, and Japan through vaccination or by combusting infected animals, however, its reemergence poses a severe danger to both domestic and wild wildlife in such countries (Foxell, 2003;Neumann, 2012). As a result, FMD is now regarded as the most dangerous epizootic threatening illness in the globe (Lazarus et al, 2015;Singh et al, 2019). Bangladesh, India, Burma, Nepal, Pakistan, Cambodia, Laos, Vietnam, and Thailand are still affected by FMDV serotypes O, A, and Asia 1, where serotype 'O' has been a prevalent serotype in Southeast Asia for many years, particularly in Bangladesh (Shahiduzzaman et al, 2016;Brito et al, 2017;Blacksell et al, 2019;Arju et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Molecular detection and adaptation of FMD virus serotype type O in BHK-21 cell line by RT-PCR

Ullah

Hoque

Nasiruddin

et al. 2023

Asian J. Med. Biol. Res.

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One of the viral diseases affecting both domestic and wild animals in many countries around the world is foot and mouth disease (FMD). The livestock sector has been suffering significant financial losses for many years as a result of the disease. The present research work was focused on the isolation, documentation and serotyping of the Foot and Mouth Disease (FMD) virus from different locations. Reverse Transcription Polymerase Chain Reaction (RT-PCR) was used to detect the FMD virus (FMDV) serotype-O that is currently circulating in the BHK-21 cell line. All the tested samples were positive for FMDV and specific for serotype-O was 64.67-52.67% from tongue epithelium tissues and 30.67-16.67% from foot tissues respectively based on locations. In BHK-21 cell lines, the viruses caused cytopathic effects such as rounding, enlargement, intercellular bridge breakdown, and finally, death of cells, which shows the presence of the FMD virus under an inverted microscope. The BHK-21 cell culture fluid was found positive for FMDV in cell culture and also was positive based on CPE. Once more, the resulting inoculum was used to serotype the virus using RT-PCR. Based on the result of the RT-PCR method, the conclusion reached was that the serotype of the FMD virus was ‘Type O’. Asian J. Med. Biol. Res. 2023, 9 (2), 14-22

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“…In spite of the annual FMD burden in Nigeria, seroepidemiology and serotyping studies for FMD infections are inadequate. e current trend of FMD occurrence in Nigeria showed that there are regular outbreaks, poor control measures, and lack of enforcement of legislation guiding disease reporting to veterinary authority [24,25]. e presence of antibodies to FMDV in several wildlife species has been documented in studies conducted in different countries of Africa mainly eastern and southern regions [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Foot and Mouth Disease Virus Infection in Some Wildlife and Cattle in Bauchi State, Nigeria

Atuman

Kudi

Abdu

et al. 2020

Veterinary Medicine International

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Foot and mouth disease (FMD) is an important transboundary viral disease of both domestic and wild cloven-hoofed animals characterized by high morbidity with devastating consequence on the livestock worldwide. Despite the endemic nature of FMD in Nigeria, little is known about the epidemiology of the disease at the wildlife-livestock interface level. To address this gap, blood samples were collected between 2013 and 2015 from some wildlife and cattle, respectively, within and around the Yankari Game Reserve and Sumu Wildlife Park in Bauchi State, Nigeria. Wild animals were immobilized using a combination of etorphine hydrochloride (M99 ® Krüger-Med South Africa) at 0.5-2 mg/kg and azaperone (Stresnil ® , Janssen Pharmaceuticals (Pty.) Ltd., South Africa) at 0.1 mg/kg using a Dan-Inject ® rifle (Dan-Inject APS, Sellerup Skovvej, Denmark) fitted with a 3 ml dart syringe and for reversal, naltrexone (Trexonil ® Kruger-Med South Africa) at 1.5 mg IM was used, and cattle were restrained by the owners for blood collection. Harvested sera from blood were screened for presence of antibodies against the foot and mouth disease virus (FMDV) using the PrioCHECK ® 3ABC NSP ELISA kit, and positive samples were serotyped using solid-phase competitive ELISA, (IZSLER Brescia, Italy). Out of the 353 sera collected from cattle and wildlife 197 (65.7%) and 13 (24.5%) (P < 0.05), respectively, tested positive for antibodies to the highly conserved nonstructural 3ABC protein of FMDV by the FMDV-NS blocking ELISA. Classification of cattle into breed and sex showed that detectable antibodies to FMDV were higher (P < 0.05) in White Fulani 157 (72.8%) than in Red Bororo 23 (39.7%) and Sokoto Gudali 17 (33.3%) breeds of cattle, whereas in females, detectable FMDV antibodies were higher (P < 0.05) 150 (72.8%) than in males 47 (50.0%). In the wildlife species, antibodies to FMDV were detected in the waterbucks 2 (28.6%), elephant 1 (25.0%), wildebeests 4 (33.3%), and elands 6 (25.0%). Four serotypes of FMDV: O, A, SAT 1, and SAT 2 were detected from the 3ABC positive reactors in waterbucks, elephants, wildebeests, and elands. e results showed presence of antibodies to FMDV in some wildlife and cattle and suggested that wildlife could equally play an important role in the overall epidemiology of FMD in Nigeria. FMD surveillance system, control, and prevention program should be intensified in the study area.

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Serological response of commercial dairy cattle to inactivated foot-and-mouth disease vaccine (type-O & A) in Nigeria

Cited by 4 publications

References 16 publications

Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria

Spatial pattern of foot-and-mouth disease virus serotypes in North Central Nigeria

Molecular detection and adaptation of FMD virus serotype type O in BHK-21 cell line by RT-PCR

Seroprevalence of Foot and Mouth Disease Virus Infection in Some Wildlife and Cattle in Bauchi State, Nigeria

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