Serological Relationships Among Meningococci

Branham, Sara E.

doi:10.1128/mmbr.17.3.175-188.1953

Cited by 43 publications

(19 citation statements)

References 18 publications

(22 reference statements)

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“…Neisseria meningitidis is divided into a number of serogroups on the basis of variation in the capsular polysaccharide (Branham, 1958;Evans etal.. 1968). The organism is further divided into serotypes on the basis of variation in the class 2 or 3 outer membrane protein (OMP) (Frasch et ai, 1985), and may also be sero-subtyped on the basis of variation in the class 1 OMP (Abdillahi and Poolman.…”

Section: Introductionmentioning

confidence: 99%

Identification and characterization of a novel insertion sequence, IS1106, downstream of the porA gene in B15 Neisseria meningitidis

Knight

Cartwright

et al. 1992

Molecular Microbiology

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Examination of Neisseria meningitidis strains associated with endemic meningococcal disease demonstrated differences in the number of copies of a repetitive sequence. Characterization of a copy of this repetitive sequence present in B15 strains has revealed the presence of a novel insertion sequence (IS1106) located within a complex repetitive region downstream of the gene for the major surface antigen (porA). IS1106 has a length of 1137 bp and is flanked by 36bp inverted repeats. Two open reading frames (ORF1 and ORF2) are present in opposite strands in codon-codon register with ORF2 entirely located within ORF1. The predicted protein from ORF1 demonstrates homology with the 5A protein of IS5 (Kroger and Hobom, 1982). Strains from two independent outbreaks of B15 meningococcal disease in the UK were found to contain the same genomic deletion removing a copy of IS1106 downstream of the porA gene.

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Section: Introductionmentioning

confidence: 99%

Identification and characterization of a novel insertion sequence, IS1106, downstream of the porA gene in B15 Neisseria meningitidis

Knight

Cartwright

et al. 1992

Molecular Microbiology

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“…B, C, D, X, Y, Z, W-135, 29E, H, I, K, and L, are recognized (2,4,8,9,19). In addition, there are strains that are nongroupable, i.e.…”

mentioning

confidence: 99%

Early development in healthy children of serum opsonins against nonpathogenic Neisseria meningitidis

Fredlund

Selldén

Danielsson

et al. 1992

APMIS

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development in healthy children of serum opsonins against nonpathogenic Neisseria meningitidis. APMIS 100: 449454, 1992.In an earlier study, with the use of chemiluminescence (CL) and phagocytic killing, we could show that in the presence of serum from healthy adults polymorphonuclear leukocytes (PMNL) efficiently handle nonpathogenic Neisseria meningitidis strains, in sharp contrast to those associated with clinical disease. The major part of this difference was dependent on serum factors. In the present study 84 serum samples from children 1-3, 4-6, 7-9, and 10-14 years old were studied by the CL technique according to their ability to opsonize meningococci. There was a highly significant difference (p < 0.001) in all four age groups when the CL indexes obtained with the pathogenic meningococci of the serogroups A, B and C were compared with those of the nonpathogenic menigococci: serogroup 29E and nongroupable meningococci. These findings imply that the ability to opsonize so-called nonpathogenic meningococci is developed early in life and may explain why they are only occasionally able to cause disease.

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“…The consequences of this variability for meningococcal serotyping cannot be estimated yet, perhaps some immunodeterminants on these proteins may nevertheless be suitable for typing purposes. The variable MOMPs contain many of the type-specific meningococcal immunodeterminants characterised so far: prototype 2a, 6,9,12,14,15,16 strains contain type-specific immunodeterminants on the 43-46000 MOMPs whereas the protype 2a, 2b, 9, 12, 13 strains do so on the 25-32000 MOMPs (see also Fig. 3) [17].…”

Section: Discussionmentioning

confidence: 99%

“…The epidemiological investigations of meningococcal diseases depend mainly upon classification schemes which use differences among meningococci regarding cell wall molecules. Serogrouping (A, B, C, X, Y, Z, Z' ( = 29E), W-135) is based on heterogeneity of the capsular polysaccharides [14][15][16], serotyping depends upon the heterogeneity of lipopolysaccharides (LPS) and major outer membrane proteins (MOMPs) [ 1,17,18].…”

Section: Meningococci ( Neisseria Meningitidis ) Arementioning

confidence: 99%