Serological Evidence of Recent Dengue Virus Infection Among Febrile Children in a Semi Arid Zone

Faneye, Adedayo Omotayo; Nioma, Idika; Motayo, Babatunde Olanrewaju; Adesanmi, Adeyinka; Ebele, Afocha

doi:10.3844/ajidsp.2013.7.10

Cited by 25 publications

(14 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Incidentally, a positive IgM result on plasma sample suggests the infection occurs in the previous one to two months before sample collection [19] . Although, higher prevalence was recently reported in some studies in Nigeria [20,21] , the testing method used for these studies predisposes to cross-reactivity to other flavivirus infections or yellow fever vaccination, as IgG screening technique was adopted by most of these researchers who worked on symptomatic patients.…”

Section: Discussionmentioning

confidence: 99%

Dengue Virus Infection among Voluntary Blood Donors in Osogbo, Southwestern Nigeria

Muhibi¹,

Adeleke²,

Shittu³

et al. 2017

Am. J. Biomed. Sci.

View full text Add to dashboard Cite

Dengue virus is one of the causative agents of viral haemorrhagic fever, which is transmitted primarily through Aedes mosquitoes. Transmission of the virus through non-vector sources had been proven, although, it is the most common arthropod-borne viral infection in human. This study was carried out to determine the prevalence of Dengue Virus amongst voluntary blood donors in Osogbo, southwest Nigeria. Ninety one voluntary non-remunerated donors that satisfied donor suitability criteria in Nigeria; having been considered fit based on physical assessment, responses provided to Blood Donors' questionnaire, and tested negative by both rapid diagnostic and ELISA techniques to HIV 1 & 2, HBV, HCV and syphilis were screened for antiDengue IgM antibody using Enzyme Linked Immuno-Sorbent Assay (ELISA). It was observed that most of the donors (56.04%) fall within age group 28-37 years, while none of the participant was older than 47. In terms of gender distribution, men (86.81%) were in the majority. Marital profile showed that most of the participants were unmarried (72.53%); while literates account for 58.24%. The seroprevalence of IgM antibodies showed that only two (2.2%) participants were positive for Dengue virus. Result showed that there is low prevalence of Dengue virus among voluntary blood donors in Osogbo. Monitoring the trends in prevalence of transmissible infectious agents in blood donors will provide a mechanism to evaluate the safety of the blood supply. It is hereby recommended that surveillance be sustained on all emerging and reemerging infectious diseases that have potentials of being transmitted through blood transfusion, dengue virus inclusive.

show abstract

Section: Discussionmentioning

confidence: 99%

Dengue Virus Infection among Voluntary Blood Donors in Osogbo, Southwestern Nigeria

Muhibi¹,

Adeleke²,

Shittu³

et al. 2017

Am. J. Biomed. Sci.

View full text Add to dashboard Cite

show abstract

“…To highlight the growing importance of dengue in Nigeria, recent seroprevalence surveys conducted in Maiduguri (Northern Nigeria)21 and in Ilorin (Western Nigeria)9 showed that 10.1% and 30.8% of participants respectively, were seropositive for dengue subtype-3 virus (DENV-3). Additionally, dengue IgM sero-prevalence among febrile Nigerian children in South-Western Nigeria has been reported to be 17.2% and 30.8% respectively 22,23. These high prevalence figures of symptomatic dengue virus infections and of dengue IgM antibodies are indicative of potential endemicity of dengue and of the plausibility of many missed infections by frontline health workers.…”

Section: Dengue In West Africa and Nigeriamentioning

confidence: 99%

Dengue fever – an update review and implications for Nigeria, and similar countries

Otu¹,

Ebenso²,

Etokidem³

et al. 2019

Afr H. Sci.

View full text Add to dashboard Cite

BackgroundIn the last five decades, dengue has emerged as one of the most important infectious diseases, following a 30-fold increase in global incidence throughout tropical and sub-tropical regions of the world. The actual numbers of dengue cases are under-reported and many cases are misclassified.ObjectivesThis article describes the epidemiology, pathophysiology, clinical features and management of dengue. It also explores the implications of infection with this flavivirus for Nigeria, and similar countries.MethodsThe literature search for publications on dengue in West Africa was performed using PubMed, African Journals Online (AJOL), Google Scholar, Web of Science, databases and grey literature to identify all published papers regarding the topic. A snowballing strategy was adopted to identify additional publications.ResultsRecent reports suggest that dengue is a growing public health problem in Nigeria, the magnitude of which needs to be more clearly defined. Nigeria, the most populous country in Africa has an abundance of the Aedes aegypti mosquito which is known to transmit dengue, Zika, as well as chikungunya (CHIKV) and West Nile viruses.ConclusionThis article provides practical suggestions for strengthening the dengue virus control programme in Nigeria. The Nigerian health system shares similarities with health systems in many other sub-Saharan countries. Therefore, the practical suggestions provided at the end of this review are likely to be applicable to many other African countries.

show abstract

“…None of the studies investigated the aetiologies of fever in children under 5 years in sub-Saharan Africa by screening all relevant foci of infection, thus BSI, UTI, RTI and GII together. Patients included in the studies who were selected for our review were outpatients [23][24][25][26], inpatients [20,[27][28][29][30][31][32][33] or the both [18,[34][35][36][37][38]. The mortality rate in the studies that provided this specific information ranged from 1.4 to 22.5% and specifically concerned the inpatient studies [18,20,28,29,33,34].…”

Section: Aetiologies Of Fever In Children Under 5 Yearsmentioning

confidence: 99%

“…Bacteria isolated from UTI were predominately E. coli (six of six) and Klebsiella ssp (six of six), with positive rates of 20.0-72.3% and 10.0-28.5%, followed by Staphylococcus, Proteus and Pseudomonas ( Table 2). Samples were analysed in district hospitals [18,27,28,30,[35][36][37], reference hospitals [32,38], teaching hospitals [20,23,29,35] or reference laboratories [24,26,34].…”

Section: Aetiologies Of Fever In Children Under 5 Yearsmentioning

confidence: 99%

Aetiologies of non‐malaria febrile episodes in children under 5 years in sub‐Saharan Africa

Kiemdé

Spijker

Mens

et al. 2016

Tropical Med Int Health

View full text Add to dashboard Cite

Abstractobjectives To provide an overview of the most frequent aetiologies found in febrile episodes of children under 5 years from sub-Saharan Africa.methods MEDLINE and EMBASE were searched for publications in English and French on nonmalaria fever episodes in African children under 5 years of age, which were published between January 1990 and July 2015. Case reports and conference abstracts were excluded.results In total, 3851 titles and abstracts were reviewed, and 153 were selected for full screening of which 18 were included in the present review. Bloodstream infection (BSI) was most commonly investigated (nine of 18) followed by urinary tract infection (UTI) (four of 18) and respiratory tract infection (RTI) (two of 18). Few studies investigated BSI and UTI in the same children (two of 18), or BSI and gastrointestinal infection (GII) (one of 18). As for BSI, the most frequently isolated bacteria were E. coli (four of 12), Streptococcus pneumonia (four of 12), Salmonella spp (three of 12) and Staphylococcus aureus (two of 12) with a positive identification rate of 19.7-33.3%, 5.2-27.6%, 11.7-65.4% and 23.5-42.0%, respectively. As for UTI, the main bacteria isolated were E. coli (six of six) and Klebsiella spp (six of six) with a positive rate of 20.0-72.3% and 10.0-28.5%, respectively. No bacterium was isolated in RTI group, but Human influenzae A and B were frequently found, with the highest positive identification rate in Tanzania (75.3%). Dengue virus (two of 12) was the most frequently reported viral infection with a positive identification rate of 16.7-30.8%. Finally, only rotavirus/adenovirus (69.2% positive identification rate) was found in GII and no bacterium was isolated in this group.conclusions The high prevalence of treatable causes of non-malaria fever episodes requires a proper diagnosis of the origin of fever followed by an appropriate treatment, thereby reducing the under-5 mortality in sub-Saharan Africa and preventing the overprescription of antibiotics and thus circumventing the rise of antibiotic resistance.

show abstract

Serological Evidence of Recent Dengue Virus Infection Among Febrile Children in a Semi Arid Zone

Cited by 25 publications

References 8 publications

Dengue Virus Infection among Voluntary Blood Donors in Osogbo, Southwestern Nigeria

Dengue Virus Infection among Voluntary Blood Donors in Osogbo, Southwestern Nigeria

Dengue fever – an update review and implications for Nigeria, and similar countries

Aetiologies of non‐malaria febrile episodes in children under 5 years in sub‐Saharan Africa

Contact Info

Product

Resources

About