“Serological biopsy” and screening of gastric cancer

Бордин, Д. С.; Бяхов, М. Ю.; Fedulenkova, L.

doi:10.18027/2224-5057-2014-2-30-36

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Консенсусом «Маастрихт-4» рекомендовано определение концентрации маркеров атрофии в сыворотке крови, этими биомаркерами являются -пепсиноген 1 и пепсиноген 2 [58]. Измерение сывороточных пепсиногенов и определение их соотношения считается эффективным методом идентификации пациентов с высоким риском рака желудка.…”

Section: возможности диагностикиunclassified

Modern possibilities and prospects of early diagnosis of stomach cancer

Архипова

Анищенко

2021

Acta biomedica scientifica

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The review includes 70 articles, most of which have been published for the last 5 years. The aim of the review: explore the modern possibilities and prospects of early diagnosis of stomach cancer. In 2018 in Russia, the mortality rate within one year after the diagnosis was 47.4 %. Leading experts in luminal endoscopy from Japan, where more than 60 % cases of stomach cancer are detected at an early stage, recommend using advanced endoscopic equipment for routine diagnostics, which allows enlarging the image, examining the capillaries of the mucosa and taking series of pictures. Artificial intelligence improves accuracy. Gastroscopic study with artificial intelligence compensates errors and limited capabilities of people, and provides greater accuracy. However, this technology is expensive, and esophagogastroduodenoscopy itself is an invasive method and can be used only in a clinical setting. In patients with a detectable lesion, a biopsy should be performed. It is important to obtain a sufficient amount of tissue when collecting material, however, many patients take anticoagulants, and thus sampling of numerous fragments can lead to bleeding. Given the limitations of esophagogastroduodenoscopy with biopsy and the fact that only 12.4 % cases of stomach cancer in 2018 in Russia identified on the stage I, the searching of effective diagnostic tools is still relevant. MicroRNAs have been in the «cancer research arena» for over 10 years and are considered biomarkers that can help to differentiate between the patients with normal range, dysplasia and those with cancer. MicroRNA regulates all vital processes of a cell, moreover, they are stable and easily extracted from various biological materials, including tissues, blood, feces, saliva, ascitic fluid and even paraffin blocks. And although microRNAs are only entering clinical practice, the results obtained are encouraging

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Section: возможности диагностикиunclassified

Modern possibilities and prospects of early diagnosis of stomach cancer

Архипова

Анищенко

2021

Acta biomedica scientifica

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Helicobacter pylori as a risk factor for gastric cancer: the evidence and primary prevention strategy

et al. 2019

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Russia is a country with a high prevalence of Helicobacter pylori (HP) infection, a high incidence of gastric cancer, and its late diagnosis. HР infection has been recognized as the leading manageable risk factor for gastric cancer. Accurate diagnostic tests must be used to identify and control the effectiveness of HP eradication, and effective schemes must be implemented for HP eradication. The aim of this article was to analyze the latest consensus documents, systematic reviews and meta-analyzes that reflected the role of HP as a risk factor for the development of gastric cancer, as well as measures for the risk reduction. We describe in detail the diagnostic methods for HP infection, provide data on their use in the Russian Federation, and analyze the efficacy of eradication regimens. In all HPinfected individuals, HP leads to chronic inflammation in the gastric mucosa and launches a precancerous cascade (Correa's cascade). The risk of gastric cancer increases with severe atrophy, intestinal metaplasia and dysplasia. Primary prevention of gastric cancer is most effective if the eradication is performed before atrophic gastritis develops. The available consensus documents underline the importance of HP infection identification by accurate diagnostics at this stage of chronic gastritis. In Russia, the primary HP diagnosis is based on histology (37.7%), rapid urease test (29.2%), and serology (29.7%). HP stool antigen test (31.3%), 13C-urea breath test (23.4%) and the histological method (23.3%) are most often used to control eradication. Currently, the first line of eradication therapy is recommended as triple therapy with clarithromycin prescribed for 14 days. It is recommended to use double dose of proton pump inhibitors and bismuth to increase the effectiveness of this scheme. A 14-days triple regimen enhanced by bismuth has been recommended as the first-line therapy in the Russian Federation.

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“Serological biopsy” and screening of gastric cancer

Cited by 2 publications

References 23 publications

Modern possibilities and prospects of early diagnosis of stomach cancer

Modern possibilities and prospects of early diagnosis of stomach cancer

Helicobacter pylori as a risk factor for gastric cancer: the evidence and primary prevention strategy

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