Serological and molecular survey of zoonotic visceral leishmaniasis in stray dogs (Canis familiaris) from an endemic focus in Meshkin-Shahr district in Ardabil province, Iran

Tabatabaie, Fatemeh; Nasirikaleybar, Yashar; Mohebali, Mehdi; Solgi, Rahmat; Babaei, Vahid; Heidari, Zahra; Orujzadeh, Fariba; Zarei, Zabihollah

doi:10.4103/0972-9062.325636

Cited by 2 publications

(3 citation statements)

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“…infantum . This result aligns with earlier studies conducted in nearby and other Mediterranean areas [ 25 – 27 ]. Detecting L .…”

Section: Discussionsupporting

confidence: 93%

“…The size of amplified bands of the kDNA in all samples, including humans, dogs, and sandflies, was 720 bp, which coordinates with the expected size for L. infantum. This result aligns with earlier studies conducted in nearby and other Mediterranean areas [25][26][27]. Detecting L. infantum parasites in various samples (humans, dogs, and sandflies) in Kaleybar and Khoda-Afarin Counties brings up several important points; 1) It suggests that visceral leishmaniasis caused by L. infantum is a significant health concern, highlighting the need for targeted public health interventions to reduce the disease burden, 2) the tracing of DNA of L. infantum in domestic dog samples confirms their role as reservoir hosts and contributes to the parasite's spread.…”

Section: Plos Onesupporting

confidence: 93%

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Detection and phylogenetic analysis of kinetoplast DNA of Leishmania infantum infected humans, domestic dogs and sandflies in Northwest Iran

Behniafar,

Taghipour,

Spotin

et al. 2024

PLoS ONE

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Leishmaniasis refers to a disease with a wide range of manifestations; and there are three main forms of disease, cutaneous, mucocutaneous, and visceral. Leishmaniasis is one of the diseases with a protozoan agent which is vector-borne. Visceral leishmaniasis (VL) is the most severe form that can be fiercely life-threatening if left untreated. VL can be caused by members of Leishmania donovani complex, in Iran, Leishmania infantum is considered the primary causative agent of VL, resulting in a zoonotic form of VL. The two main goals of our work, which followed our prior sero-epidemiological and entomological survey, were to characterize and conduct a phylogenetic analysis of the Leishmania species that infect people, dogs, and sandflies. The samples were collected throughout 2017, from January to December, so blood samples were collected from humans and dogs, while sandfly samples were collected with sticky traps. DNA extracted from all seropositive samples of humans and dogs, 10% of sero-negative human samples, and all collected sandflies were subjected to kDNA-nested-PCR for tracing parasites. A total of 30 samples, including 20 human samples, 8 dog samples, and 2 sandfly samples, were found positive for the kDNA gene of L. infantum. Sequences were evaluated to study the genetic diversity among the six discovered L. infantum. Based on kDNA, the phylogenetic study of L. infantum demonstrated a high level of genetic variety and a relationship between the host, the parasite’s geographic origin, and its genetic diversity.

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“…infantum . This result aligns with earlier studies conducted in nearby and other Mediterranean areas [ 25 – 27 ]. Detecting L .…”

Section: Discussionsupporting

confidence: 93%

Section: Plos Onesupporting

confidence: 93%

Detection and phylogenetic analysis of kinetoplast DNA of Leishmania infantum infected humans, domestic dogs and sandflies in Northwest Iran

Behniafar,

Taghipour,

Spotin

et al. 2024

PLoS ONE

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“…However, due to being an accidental host, the number of human infections is rare. Infectious rodents with this nematode have been reported by Kia et al 31 and Zarei et al 51 from the northwest, Moradpour et al 17 from the east and west, and Pakdel et al 27 and Kazemi et al 52 from western regions of Iran. Regarding the hosts, almost 80 species of rodents in the family Muridae, as well as about 24 species of mammals, including humans, could be infected with this parasite [53][54] .…”

Section: Discussionmentioning

confidence: 86%

Investigation of Potentially Zoonotic Helminth Parasites of Allactaga elater in Sarakhs, Iran

Shahrokhi,

Moradpour,

Siahsarvie

et al. 2022

J Lab Anim. Res

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Introduction: Rodents are the reservoir of many endoparasites and act as their intermediate or final hosts. This study aimed to assess parasitic helminths of Allactaga elater in Sarakhs, Khorasan Razavi Province, northeastern Iran. Material and methods: From August 2017 to February 2018, 33 Allactaga elater were collected using live traps. All Allactaga elaters were euthanized, and their gastrointestinal tracts were removed and examined to identify parasitic helminths. Finally, parasites were identified using key morphological characteristics. Results: Overall, 91% of Allactaga elaters were infected with helminths, including Syphacia obvelata (86.6%), Aspicularis tetraptera (36.6%), Trichuris spp (13.3%), Heligmosomoides polygyrus (3.3%), Hymenolepis nana (16.6%), Hymenolepis diminuta (16.6%), and Cysticercus fasciolaris (13.3%). Conclusion: Various species of helminths were found in Allactaga elater from the studied area. These findings highlight the importance of this rodent species as a reservoir for zoonotic helminths.

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Serological and molecular survey of zoonotic visceral leishmaniasis in stray dogs (Canis familiaris) from an endemic focus in Meshkin-Shahr district in Ardabil province, Iran

Cited by 2 publications

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Detection and phylogenetic analysis of kinetoplast DNA of Leishmania infantum infected humans, domestic dogs and sandflies in Northwest Iran

Detection and phylogenetic analysis of kinetoplast DNA of Leishmania infantum infected humans, domestic dogs and sandflies in Northwest Iran

Investigation of Potentially Zoonotic Helminth Parasites of Allactaga elater in Sarakhs, Iran

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