Serologic Screening of Pregnant Korean Women for Primary Human Cytomegalovirus Infection Using IgG Avidity Test

Seo, Soyeon; Cho, Young-Sook; Park, Joonseok

doi:10.3343/kjlm.2009.29.6.557

Cited by 52 publications

(44 citation statements)

References 14 publications

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“…This is in agreement with studies in other region; 4 % in Nigeria [41], 8.1 % in Kenya [19], 6 % in Sudan [40]. However, our finding is in contrast with other studies in similar setting [39] and 2.5 % in Iran [43], 1.7 % in Korea [44]. This might be because of high numbers of immune compromised participants and toddlers, socio-economic and geographical distribution difference.…”

Section: Discussionsupporting

confidence: 91%

Maternal and Congenital cytomegalovirus infection and zero rubella IgM prevalence in newborns in St.Paul’s Hospital Millennium Medical College

et al. 2016

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BackgroundMaternal cytomegalovirus (CMV) and Rubella infections result in adverse neonatal outcomes. Both CMV and Rubella are more widespread in developing countries and in communities with lower socioeconomic status. Thus, the aim of this study was to determine IgM specific to CMV and Rubella among newborns and Maternal CMV-seroprevalence and to identify risk factors.Method and findingUsing cross sectional study design a total of 312 (156 newborns and 156 mothers) study participants were recruited by simple random sampling technique from gynecology outpatient department (OPD) and ward, starting from April 1, 2015 to June 30, 2015. Cord and venous blood samples were collected from all participants and structured questionnaire was introduced to gather risk factor related data. ELISA was used to detect CMV and Rubella-IgM. SPSS version 20 was used to analyze the data, and regression analysis was also performed. Out of 156 newborns, 2 [1.3 %; 95 % CI: 0.0–3.8] were positive for CMV—IgM and no single rubella was detected. Association was not computed between risk related variables and cytomegalovirus infected newborns due to the low positivity rate. Multiple independent predictors were found between maternal CMV-IgM and Obstetrical characteristics. Cytomegalovirus—IgM was significantly isolated from mothers with history of transfusion (25.0 %, OR 0.09, 95 % CI 0.0–0.3, P = 0.006), history of abortion (OR 0.02, 95 % CI 0.0–0.6, P = 0.023), HIV sero-status (OR 5.0, 95 % CI 1.5–15.8, P = 0.034), and multi parity (OR 0.08, 95 % CI 0.01–0.7, P = 0.022).ConclusionAlthough low congenital CMV and no Rubella are reported among newborns, more effort is needed to screen for congenital infectious viral disease as well as usage of advanced techniques should be taken into consideration.Electronic supplementary materialThe online version of this article (doi:10.1186/s13104-016-2274-1) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 91%

Maternal and Congenital cytomegalovirus infection and zero rubella IgM prevalence in newborns in St.Paul’s Hospital Millennium Medical College

et al. 2016

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“…This finding was 4–7 times higher than those in other different developing countries; 4% in Nigeria (16), 6% in Sudan (14), 2.5% in Iran (21), 1.7% in Korea (22) and/or even developed world studies from Belgium, Brazil, Taiwan, Cuba and Finland (23–27). This might be due to low socio-economic status, the number of toddlers and poor hygienic practice.…”

Section: Discussionmentioning

confidence: 67%

Seroepidemiology study of cytomegalovirus and rubella among pregnant women at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

Mamuye

Nigatu

Bekele

et al. 2016

Ethiop J Health Sci

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“…In this population, CMV acquisition occurs at a rate of 1 to 7% per year (31) and usually follows frequent and prolonged contact with young children (less than 3 years of age) (31)(32)(33)(34). By comparison, in resource-poor communities in industrialized countries and in developing countries, CMV is usually acquired very early in life owing to breast milk transmission and crowded living conditions, and far fewer adult women are seronegative (7,(35)(36)(37)(38)(39)(40)(41).…”

Section: Epidemiology and Clinical Outcomesmentioning

confidence: 99%

The “Silent” Global Burden of Congenital Cytomegalovirus

et al. 2013

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SUMMARYHuman cytomegalovirus (CMV) is a leading cause of congenital infections worldwide. In the developed world, following the virtual elimination of circulating rubella, it is the commonest nongenetic cause of childhood hearing loss and an important cause of neurodevelopmental delay. The seroprevalence of CMV in adults and the incidence of congenital CMV infection are highest in developing countries (1 to 5% of births) and are most likely driven by nonprimary maternal infections. However, reliable estimates of prevalence and outcome from developing countries are not available. This is largely due to the dogma that maternal preexisting seroimmunity virtually eliminates the risk for sequelae. However, recent data demonstrating similar rates of sequelae, especially hearing loss, following primary and nonprimary maternal infection have underscored the importance of congenital CMV infection in resource-poor settings. Although a significant proportion of congenital CMV infections are attributable to maternal primary infection in well-resourced settings, the absence of specific interventions for seronegative mothers and uncertainty about fetal prognosis have discouraged routine maternal antibody screening. Despite these challenges, encouraging results from prototype vaccines have been reported, and the first randomized phase III trials of prenatal interventions and prolonged postnatal antiviral therapy are under way. Successful implementation of strategies to prevent or reduce the burden of congenital CMV infection will require heightened global awareness among clinicians and the general population. In this review, we highlight the global epidemiology of congenital CMV and the implications of growing knowledge in areas of prevention, diagnosis, prognosis, and management for both low (50 to 70%)- and high (>70%)-seroprevalence settings.

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Serologic Screening of Pregnant Korean Women for Primary Human Cytomegalovirus Infection Using IgG Avidity Test

Cited by 52 publications

References 14 publications

Maternal and Congenital cytomegalovirus infection and zero rubella IgM prevalence in newborns in St.Paul’s Hospital Millennium Medical College

Maternal and Congenital cytomegalovirus infection and zero rubella IgM prevalence in newborns in St.Paul’s Hospital Millennium Medical College

Seroepidemiology study of cytomegalovirus and rubella among pregnant women at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

The “Silent” Global Burden of Congenital Cytomegalovirus

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