Serologic markers of autoimmunity in women with polycystic ovary syndrome

Hefler-Frischmuth, Katrin; Walch, Katharina; Huebl, Wolfgang; Baumuehlner, Konstantin; Tempfer, Clemens B.; Hefler, Lukas

doi:10.1016/j.fertnstert.2009.01.056

Cited by 67 publications

(56 citation statements)

References 29 publications

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“…Besides, they also observed that 42.3% of PCOS subjects had hypoechoic tissue pattern typical of autoimmune thyroiditis on USG in comparison to 6.5% in controls (P!0.001). Familial aggregation and genetic predisposition of these two apparently diverse disorders along with a recent study demonstrating high prevalence of serologic parameters of autoimmunity (anti-histone and anti-dsDNA antibodies) in women with PCOS may suggest the role of autoimmunity in the pathogenesis of PCOS (13)(14)(15)(16)(17)24). Similar findings supporting a potential link between PCOS and autoimmunity have been reported by two other groups (25,26).…”

Section: Discussionsupporting

confidence: 79%

High prevalence of polycystic ovary syndrome characteristics in girls with euthyroid chronic lymphocytic thyroiditis: a case–control study

Ganie

Marwaha

Aggarwal

et al. 2010

European Journal of Endocrinology

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Objective: The aim was to find the prevalence of polycystic ovary syndrome (PCOS) phenotype in adolescent euthyroid girls with chronic lymphocytic thyroiditis (CLT). Design: This was a prospective case-control study as part of an ongoing community-wide thyroid survey in Indian schools. Methods: One hundred and seventy-five girls with euthyroid CLT and 46 age-matched non-CLT girls underwent clinical, biochemical, hormonal, and ultrasonographic evaluation for diagnosis of PCOS by Rotterdam 2003 criteria. All subjects underwent serum sampling for LH, FSH, testosterone, DHEAS, free thyroxine, TSH, and anti-thyroid peroxidase (TPO) antibodies. Oral glucose tolerance test (OGTT) was undertaken for plasma glucose and insulin. Results: Significantly higher prevalence of PCOS was noted in girls with euthyroid CLT when compared to their control counterparts (46.8 vs 4.3%, PZ0.001). The CLT girls had higher body mass index, waist circumference, and systolic blood pressure (PZ0.001). Mean number of menstrual cycles/year was 8.4G3.5 vs 10.1G1.4, and mean Ferriman-Gallwey score was 11.9G3.5 vs 3.0G2.4 (PZ0.001) in cases versus controls respectively. The fasting and postprandial glucose and serum cholesterol were also higher in the cases (PZ0.001). Homeostasis model assessment-insulin resistance was 4.4G4.2 vs 2.3G2.7 in the cases versus controls (PZ0.001). Conclusion: Higher prevalence of PCOS characteristics in euthyroid CLT girls when compared to controls suggest possible role of autoimmune phenomenon in the etiopathogenesis of PCOS. Further studies are required to understand the pathogenic link between these two disorders.

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Section: Discussionsupporting

confidence: 79%

High prevalence of polycystic ovary syndrome characteristics in girls with euthyroid chronic lymphocytic thyroiditis: a case–control study

Ganie

Marwaha

Aggarwal

et al. 2010

European Journal of Endocrinology

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“…We found that patients with PCOS have significantly higher levels of anti-dsDNA and anti-histone antibodies compared to those with unexplained infertility and healthy fertile subjects. These findings are consistent with previous studies [8,9] suggestive of an autoimmune etiology in pathogenesis of PCOS. We also found that laparoscopic ovarian electrocauterization results in increased levels of anti-dsDNA and anti-histone antibodies in patients with PCOS.…”

Section: Discussionsupporting

confidence: 94%

“…Some recent studies have shown that patients with PCOS have significantly higher levels of autoantibodies including antihistone and anti-dsDNA suggestive of autoimmune process in PCOS [8,9]. It has been also shown that PCOS is associated with some other autoimmune disorders including autoimmune thyroiditis [10].…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of Anti-histone and Anti-double-Strand DNA Antibodies Before and After Laparoscopic Ovarian Drilling in Women with Polycystic Ovarian Syndrome

Samsami

Razmjoei

Parsanezhad

2013

J Obstet Gynecol India

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Objectives To determine the serum levels of anti-dsDNA, anti-histone, and anti-nucleosome antibodies after laparoscopic ovarian electrocauterization in patients with polycystic ovarian syndrome (PCOS). Methods Our study was performed on 35 patients with PCOS resistant to medical therapy, 35 patients with unexplained infertility, and 35 healthy fertile individuals. Patients with PCOS underwent laparoscopic electrocauterization while those with unexplained infertility underwent diagnostic laparoscopy. Serum levels of anti-dsDNA, anti-histone, and anti-nucleosome antibodies were measured at baseline and 1 month after operation and were compared between groups.

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“…In two register-based studies, the relative risks of asthma were 1.5 (7) and 2.5 (10) in PCOS; these results underline the need for studies on pulmonary disease susceptibility in PCOS (7). Furthermore, the levels of various autoantibodies were higher in PCOS versus controls (6) and the risk of rheumatologic or other autoimmune diseases may also be increased in PCOS (6). Increased levels of islet autoantibodies causes destruction of the pancreatic beta cells and lead to type 1 diabetes.…”

Section: Autoimmune Inflammatory and Infectious Diseases In Pcosmentioning

confidence: 99%

“…These two factors are associated with subclinical inflammation, the metabolic syndrome, increased risk of type 2 diabetes (T2D) and may be associated with increased risk of cardiovascular disease (5). Hyperinflammation in PCOS could also affect autoimmune function (6) and thereby increase the risk of thyroid and respiratory disease (7). Furthermore, the presence of insulin resistance, obesity and hyperinflammation in PCOS theoretically increase the risk of gallstones, cancer disease and overall mortality (7).…”

Section: Introductionmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Glintborg

Andersen

2017

European Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) is the most prevalent endocrine condition in premenopausal women. The syndrome is characterized by hyperandrogenism, irregular menses and polycystic ovaries when other etiologies are excluded. Obesity, insulin resistance and low vitamin D levels are present in more than 50% patients with PCOS, these factors along with hyperandrogenism could have adverse effects on long-term health. Hyperinflammation and impaired epithelial function were reported to a larger extent in women with PCOS and could particularly be associated with hyperandrogenism, obesity and insulin resistance. Available data from register-based and data linkage studies support that metabolic-vascular and thyroid diseases, asthma, migraine, depression and cancer are diagnosed more frequently in PCOS, whereas fracture risk is decreased. Drug prescriptions are significantly more common in PCOS than controls within all diagnose categories including antibiotics. The causal relationship between PCOS and autoimmune disease represents an interesting new area of research. PCOS is a lifelong condition and long-term morbidity could be worsened by obesity, sedentary way of life, Western-style diet and smoking, whereas lifestyle intervention including weight loss may partly or fully resolve the symptoms of PCOS and could improve the long-term prognosis. In this review, the possible implications of increased morbidity for the clinical and biochemical evaluation of patients with PCOS at diagnosis and follow-up is further discussed along with possible modifying effects of medical treatment.

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Serologic markers of autoimmunity in women with polycystic ovary syndrome

Cited by 67 publications

References 29 publications

High prevalence of polycystic ovary syndrome characteristics in girls with euthyroid chronic lymphocytic thyroiditis: a case–control study

High prevalence of polycystic ovary syndrome characteristics in girls with euthyroid chronic lymphocytic thyroiditis: a case–control study

Serum Levels of Anti-histone and Anti-double-Strand DNA Antibodies Before and After Laparoscopic Ovarian Drilling in Women with Polycystic Ovarian Syndrome

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

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