Serum Levels of Anti-histone and Anti-double-Strand DNA Antibodies Before and After Laparoscopic Ovarian Drilling in Women with Polycystic Ovarian Syndrome

Samsami, Dehaghani Alamtaj; Razmjoei, Parisa; Parsanezhad, Mohammad Ebrahim

doi:10.1007/s13224-013-0451-x

Cited by 8 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In PCOS low level of progesterone overstimulates immune system that leads to production of autoantibodies and therefore it can be labeled as an autoimmune disorder [ 61 ]. Summary of the autoantibodies that have been detected so far in PCOS is given in Table 3 .…”

Section: Autoantibodies In Pcosmentioning

confidence: 99%

Polycystic Ovary Syndrome May Be an Autoimmune Disorder

2016

View full text Add to dashboard Cite

Polycystic ovarian syndrome (PCOS) is the most prevalent endocrine disorder affecting females. It is a common cause of menstrual irregularities and infertility during reproductive age. Genetic and hormonal factors play crucial role in the pathogenesis of PCOS. Low level of progesterone in PCOS causes overstimulation of immune system that produces more estrogen which leads to various autoantibodies. Different autoantibodies have been documented in PCOS, for example, anti-nuclear (ANA), anti-thyroid, anti-spermatic, anti-SM, anti-histone, anti-carbonic anhydrase, anti-ovarian, and anti-islet cell antibodies. There is an association between PCOS and autoimmune diseases such as ANA and anti-TPO that have been documented in systemic lupus erythematosus and Hashimoto thyroiditis, respectively, and it is suspected that there are autoantibodies that might affect the long term clinical management of these patients. Therefore fluctuating levels of autoantibodies in different PCOS patients give us the way to open new chapter for future research on molecular level. This may lead to discovery of better treatment options for PCOS in near future.

show abstract

Section: Autoantibodies In Pcosmentioning

confidence: 99%

Polycystic Ovary Syndrome May Be an Autoimmune Disorder

2016

View full text Add to dashboard Cite

show abstract

“…Recent evidence points to the addition of autoimmune causes to the etiopathogenesis of PCOS 4,5 . Anti‐nuclear antibodies (ANA), anti‐double stranded DNA (ds DNA) antibodies, anti‐histone antibodies were found to be high in PCOS 6,7 …”

Section: Introductionmentioning

confidence: 99%

Autoimmune regulator (AIRE): Takes a hypoxia‐inducing factor 1A (HIF1A) route to regulate FOXP3 expression in PCOS

Padmanabhan

Johnson

Dhyani

et al. 2022

American J Rep Immunol

View full text Add to dashboard Cite

Problem Autoimmune polyendocrinopathy‐candidiasis‐ ectodermal dystrophy (APECED) pathology due to autoimmune regulator (AIRE) gene mutations leads to loss of central tolerance triggering immune attack, a factor causing infertility. One of the targets of autoimmune attack is ovary and its repercussion results in polycystic ovarian syndrome (PCOS). Although reduced Tregs have been reported in PCOS, a lacunae exists on the status of AIRE gene expression and its role in treg insufficiency via HIF1A‐FOXP3 axis in PCOS. Method of study This is a case‐control cohort study recruiting 40 normal and 40 PCOS volunteers for peripheral blood sample collection and PCOS diagnoses were based on Rotterdam Consensus criteria. AIRE and HIF1A expression status was analysed by qRT PCR and western blot. FACS analyses was conducted on AIRE silenced peripheral blood mononuclear cells (PBMCs) after Treg induction. Results Our results indicate a reduced AIRE (fold change log2 (RQ) = –2.6, P < .01) and increased HIF1A (fold change log2 (RQ) = 3.6, P < .02) in PBMCs of PCOS subjects compared to age‐matched controls. Western blot of AIRE and HIF1A corroborates with qRT PCR data. Our CHIP data demonstrate AIRE mediated HIF1A promoter regulation. Silencing of AIRE in PBMCs contributes to the upregulation of HIF1A transcripts by two‐fold (P < .0015) and downregulation in FOXP3 expression by three‐fold (P < .0017). FACS analyses revealed that silencing of AIRE reduces Tcell to Treg conversion. Conclusions Our consolidated results derive a new connection among AIRE‐HIF1A‐FOXP3 with AIRE reduction enabling increased HIF1A resulting in reduced FOXP3 in PBMCs of PCOS patients leading to Treg insufficiency.

show abstract

“…Hence, the increased secretion of oestrogen hormone may lead towards the formation of autoantibodies in the body. Recently, there are two commonly recognised investigative criteria of polycystic ovarian syndrome and both suggest the presence of two out of three signs to be characterized as polycystic ovarian syndrome (PCOS) [37].…”

Section: Introductionmentioning

confidence: 99%

Prevalence, Symptomatology and Herbal Management of Polycystic Ovarian Syndrome

Sultana¹,

Akhter²,

Akram³

et al. 2021

Alternative Medicine - Update

View full text Add to dashboard Cite

Polycystic Ovarian Syndrome (PCOS) is multi-organ syndrome that affects 6–25% of females during reproductive age. It disrupts normal hormone levels of females and affects adrenal hormone and sex hormones along with pituitary hormones including adrenocorticotropic, growth hormone and gonadotropins hormones. It results in several secondary characteristics in females such as infertility, hormonal imbalance, oligomenorrhea, amenorrhea, obesity and hirsutism. Polycystic ovarian syndrome is associated with mental and reproductive disorder and almost 4–18% mature female students are affected by polycystic ovarian syndrome. Female affected by polycystic ovarian syndrome have increased risk of infertility, ovarian cancer, skin problems and psychological problems such as anxiety, depression and changes in sleep along with mood swings. This chapter discusses the Prevalence, Symptomatology and Management of Polycystic Ovarian Syndrome. For the management of PCOS, the role of some medicinal plants including Asparagus racemosus, Tinospora cordifolia, Foeniculum vulgare, Ocimum tenuiflorum, Actaea racemosa, and Lepidium meyenii have also been discussed in addition to other treatment modalities. The literature data was searched out and compiled using relevant original research articles and reviews published and indexed in Google Scholar, Scientific Information Database, Elsevier, PubMed and Science Direct.

show abstract

Serum Levels of Anti-histone and Anti-double-Strand DNA Antibodies Before and After Laparoscopic Ovarian Drilling in Women with Polycystic Ovarian Syndrome

Cited by 8 publications

References 14 publications

Polycystic Ovary Syndrome May Be an Autoimmune Disorder

Polycystic Ovary Syndrome May Be an Autoimmune Disorder

Autoimmune regulator (AIRE): Takes a hypoxia‐inducing factor 1A (HIF1A) route to regulate FOXP3 expression in PCOS

Prevalence, Symptomatology and Herbal Management of Polycystic Ovarian Syndrome

Contact Info

Product

Resources

About