Seroepidemiological Study of Toxoplasma , Rubella , Cytomegalovirus and Herpes Simplex in Women with Bad Obstetric History

Aljumaili, Zainab Khalil Mohamed; Alsamarai, Abdulghani Mohamed; Najem, Wesam Suhail

doi:10.5742/mejim.2013.66364

Cited by 9 publications

(15 citation statements)

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“…Identification of the risk factors may help to improve the control measures of HSV infection. Although there is improve in the diagnosis and treatment of TORCH infections, still it represent a problem in developing countries [18]. Clinical diagnosis of TORCH is difficult, since most of the maternal infections with adverse outcomes are initially asymptomatic.…”

Section: Introductionmentioning

confidence: 99%

“…Routine TORCH complex screening during pregnancy is not recommended in Iraq and the extent to which it is performed is unknown. Using healthcare database, seroprevalence of TORCH complex was determined among women with bad obstetric history (BOH) [18,19]. Only four studies reported concerning seroprevalence of HSV 2 in Iraqi women with bad obstetric history [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Association between Herpes Simplex virus type 2 (HSV 2) and bad obstetric outcomes

Hassan¹,

Alsamarai²,

Aljumaili³

et al. 2014

Our Dermatol Online

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Introduction: HSV is a common human pathogen that lead to lifelong latent infection. Maternal infections may be associate with transmission to the fetus. The risk factors associated with HSV 2 seropositivity in pregnant women in Iraq are not well studied. Aim: The present study conducted to verify the prevalence of HSV 2 infections in women with bad obstetric history (BOH) in Kirkuk Governorate. Material and Methods: HSV 2 seropositivity among women aged 14 to 48 years was investigated by determination of HSV 2 IgG and IgM in a prospective, case control descriptive study. Results: The overall HSV 2 seroprevalence was 29.9%, with a non significant difference between women with BOH and women with normal pregnancy. HSV 2 IgM, as an indicator of current infection was demonstrated in 2% of the studied population, and was significantly (P= 0.002) higher in women with BOH compared to women with normal pregnancy. Both HSV 2 IgG and IgM were significantly varied with age groups, with trends of increasing with older ages. HSV 2 IgG was statistically significantly higher in working women (P=0.03) as compared to housewife. Conclusions: Significant association was found between HSV 2 seroprevalence and education levels, residence, smoking and animal exposure. Presence of pregnancy in women with HSV-2 latent infection was a risk factor for development of BOH.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between Herpes Simplex virus type 2 (HSV 2) and bad obstetric outcomes

Hassan¹,

Alsamarai²,

Aljumaili³

et al. 2014

Our Dermatol Online

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“…Four of them are pregnant and thus IgG avidity confirmatory test or estimation of IgM titers to exclude recent infections are warranted [31]. T. gondii acute infections decline with time from 1.05 % to 0.9 %, but IgG seroprevalence was with different pattern [3]. The decline in IgG as a marker of remote infections may take 5 to 10 years to happen in immunocompromised individuals.…”

Section: Discussionmentioning

confidence: 99%

“…Possible reactivation of latent infection in an increasingly immunosuppressed population, however, makes toxoplasmosis an important opportunistic infection. T. gondii infection in pregnant women may lead to vertical transmission from mother to the fetus and subsequent intrauterine deformity [3].…”

Section: Introductionmentioning

confidence: 99%

Association between Toxoplasma Infection and Bad Obstetric Outcomes in Women from Kirkuk

Am¹

2018

VIJ

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Toxoplasmosis gondii infection is one of the predominant chronic infections with global distribution and characterized by regional geographical variations. The disease was with social, economic and health impact because its association with bad obstetric outcomes. To determine the association between Toxoplasma infections and bad obstetric outcomes this study was conducted as a descriptive case control study. The study included 547 women with BOH and 291 women with normal pregnancy outcome. Serological study carried out to determine T. gondii IgG and IgM using ELISA kits. T. gondii IgG overall prevalence was 24.7%. The seroprevalence was not significantly different in BOH women as compared to control, but seroprevalence was significantly lower in pregnant women (18.3%) than in non pregnant (31.5%) women.The current T. gondii infection overall rate was 0.84%, with significantly higher rate in women with BOH (1.3%).Residence influenced T. gondii IgG and IgM seroprevalence. In conclusion, Toxoplasma seropositivity was not significantly different in women with BOH as compared to control and significantly influenced by residence.

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“…Herpesviridae family has been implicated as a cause of breast cancer [1]. Both Human cytomegalovirus [HCMV] and Epstein -Barr virus [EBV] infections in Arab countries including Iraq was with high rate of infection [38][39][40][41]. Previous studies suggest that HCMV and EBV infections are linked with the development of breast cancer [42][43][44][45].…”

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confidence: 99%

Association of Human Cytomegalovirus and Epstein-Barr Virus with Breast Cancer

Alsamarai

2018

IJMS

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Breast cancer forms the most common cancer in women worldwide [1,2] and in Arab countries [3]. Breast cancer accounts for about 1/3 of the registered female cancer in Iraq [4] and with incidence rate of 31.1/ 100 000 in Iraqi women , while it was 18.4 for Iran, 22.4 for Saudi Arabia, 23.0 for Syria, 28.3 for Turkey, 47.0 for Jordan, and 47.7 for Kuwait [5,6]. Recent study in Iraq reported a trend for breast cancer to affect younger age group [7]. This study shows that the highest frequency of breast cancer (32.4%) was in women with age of 21-30 years. Unfortunately, 79.7% of breast cancer cases were in women with age of ≤ 40 years. In addition, 14.9% of breast cancer cases were in women with age of 16-18 years and 52.7% were in those with age of ≤ 30 years. This age shift pattern of breast cancer in Iraqi women was not consistent with previous studies in Iraq [6-12], Arab countries and globally [13,14]. The peak frequency of our study was 21-30 years, while previous studies in Iraq [15-21] indicated that breast cancer frequency peak was in fifth decade of life, in Asian countries in 40-50 years and it was 60-70 years in Western countries [22].

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Seroepidemiological Study of Toxoplasma , Rubella , Cytomegalovirus and Herpes Simplex in Women with Bad Obstetric History

Cited by 9 publications

References 0 publications

Association between Herpes Simplex virus type 2 (HSV 2) and bad obstetric outcomes

Association between Herpes Simplex virus type 2 (HSV 2) and bad obstetric outcomes

Association between Toxoplasma Infection and Bad Obstetric Outcomes in Women from Kirkuk

Association of Human Cytomegalovirus and Epstein-Barr Virus with Breast Cancer

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