Seroepidemiologic, Molecular, and Phylogenetic Analyses of Simian T-Cell Leukemia Viruses (STLV-I) from Various Naturally infected Monkey Species from Central and Western Africa

Saksena, Nitin K.; Hervé, Vincent; Durand, Jean Paul; Leguenno, B.; Diop, Ousmane M.; Digoutte, J. P.; Mathiot, C; Müller, Margaret; Love, Jayne L.; Dube, Syamalima; Sherman, Michael P.; Benz, Patricia; Erensoy, Selda; Galat-Luong, Ann; Galat, Gérard; Paul, Baishali; Dube, Dipak K.; Sinoussi, F. Barre; Poiesz, Bernard J.

doi:10.1006/viro.1994.1033

Cited by 95 publications

(49 citation statements)

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“…Yet among these secluded ethnic populations there is a high prevalence of other blood-borne infections such as hepatitis B virus, hepatitis C virus, and human T-lymphotrophic virus (HTLV)-1 (19,20). The very close relationships among some simian T-lymphotrophic virus-1 strains from chimpanzees and HTLV-1 subtype B strains present in pygmies (23,24) reinforce the possibility of zoonotic transmission of other retroviruses such as SIVcpz from chimpanzees to this ethnic group. Our results indicate that HHA haplotypes are associated with a delay in disease progression in individuals of African descent, although there is no evidence that HHA haplotypes are associated with a reduction in transmission risk.…”

Section: Discussionmentioning

confidence: 99%

Race-specific HIV-1 disease-modifying effects associated with CCR5 haplotypes

González

Bamshad

Sato

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

237

330

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Genetic variation in CC chemokine receptor 5 (CCR5), the major HIV-1 coreceptor, has been shown to influence HIV-1 transmission and disease progression. However, it is generally assumed that the same CCR5 genotype (or haplotype) has similar phenotypic effects in different populations. To test this assumption, we used an evolutionary-based classification of CCR5 haplotypes to determine their associated HIV-1 disease-modifying effects in a large wellcharacterized racially mixed cohort of HIV-1-seropositive individuals. We demonstrate that the spectrum of CCR5 haplotypes associated with disease acceleration or retardation differs between African Americans and Caucasians. Also, we show that there is a strong interactive effect between CCR5 haplotypes with different evolutionary histories. The striking population-specific phenotypic effects associated with CCR5 haplotypes emphasize the importance of understanding the evolutionary context in which disease susceptibility genes are expressed.

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Section: Discussionmentioning

confidence: 99%

Race-specific HIV-1 disease-modifying effects associated with CCR5 haplotypes

González

Bamshad

Sato

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

237

330

View full text Add to dashboard Cite

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“…In STLV-1-infected macaques (Macaca tonkeana) and mandrills (Mandrillus sphinx), investigators have described the clonal proliferation of STLV-1-infected cells and preferential infection of CD4 ϩ T cells (35,36). Interestingly, there is a high frequency of STLV-1 seropositivity in wild and captive baboons (37)(38)(39)(40)(41). Phylogenetic analyses of STLV-1 sequences from wild-caught chacma baboons (Papio ursinus) and olive baboons (Papio anubis) suggest cross-species transmissions of STLV-1 in the wild (30,41,42).…”

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confidence: 99%

Cellular Immune Responses against Simian T-Lymphotropic Virus Type 1 Target Tax in Infected Baboons

Castro

Giret

Magnani

et al. 2016

J Virol

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“…Therefore, characterizing STLV-1 diversity in different species of nonhuman primates and correlating this characterization with HTLV diversity may provide significant information on the mechanism of HTLV emergence. To date, studies of STLV-1 diversity in different species of monkeys and apes in Central Africa have demonstrated the presence of specific STLV-1 variants in several subspecies of baboons (Papio hamadryas, Papio anubis, and Papio doguera) (25,28,43), gelada baboons (Theropithecus gelada) (53), swamp monkeys (Allenopithecus nigroviridis) (28), grivet monkeys (Cercopithecus aethiops aethiops) (18,28), tantalus monkeys (Cercopithecus aethiops tantalus), crested mona monkeys (Cercopithecus mona pogonias) (28), Syke's monkeys (Cercopithecus albogularis) (43), patas monkeys (Erythrocebus patas) (43), mandrills (Mandrillus sphinx) (26,36), SMs (Cercocebus atys) (8,43), agile mangabeys (Cercocebus agilis) (37), chimpanzees (Pan troglodytes) (19,38,39), and gorillas (Gorilla gorilla) (38). Interestingly, although SMs are the documented source of HIV-2 (4), information concerning STLV diversity and prevalence in SMs in their natural habitats has not been reported.…”

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confidence: 99%