Molecular Epidemiology of Simian T-Cell Lymphotropic Virus Type 1 in Wild and Captive Sooty Mangabeys

Traina‐Dorge, Vicki; Lorino, Rebecca; Gormus, Bobby J.; Metzger, Michael J.; Telfer, Paul; Richardson, David; Robertson, David L.; Marx, Preston A.; Apetrei, Cristian

doi:10.1128/jvi.79.4.2541-2548.2005

Cited by 14 publications

(12 citation statements)

References 54 publications

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“…Simian T-lymphotropic viruses (STLVs) are members of the primate T-lymphotropic virus group of related retroviruses (STLV-2, STLV type L, STLV-3) and their human T-celllymphotropic virus counterparts, which share common morphological, antigenic, biological, and genetic features (Traina-Dorge et al, 2005). STLV is endemic in many wild and captive African and Asian monkeys and apes, and is usually asymptomatic, with only a small number of infected animals developing T-cell lymphoma or lymphoproliferative disease (Lerche and Osborn, 2003).…”

Section: Introductionmentioning

confidence: 99%

Overview of known non-human primate pathogens with potential to affect colonies used for toxicity testing

Sasseville

Mansfield

2009

Journal of Immunotoxicology

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Section: Introductionmentioning

confidence: 99%

Overview of known non-human primate pathogens with potential to affect colonies used for toxicity testing

Sasseville

Mansfield

2009

Journal of Immunotoxicology

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“…STLV is endemic in many wild and captive African and Asian monkeys and apes, with seroprevalence ranging from 0% to 80% (Andrade et al 2003;Lerche and Osborn 2003;Sariol et al 2006;Traina-Dorge et al 2005).…”

Section: Retroviruses (Simian Type D Retrovirus Simianmentioning

confidence: 99%

“…Simian T lymphotropic virus 1 (STLV-1) belongs to the primate T lymphotropic virus (PTLV) group of related retroviruses that includes STLV-2, STLV type L, STLV-3, and their human T cell lymphotropic virus counterparts, which share common morphological, antigenic, biologic, and genetic features (Traina-Dorge et al 2005). STLV is endemic in many wild and captive African and Asian monkeys and apes, with seroprevalence ranging from 0% to 80% (Andrade et al 2003;Lerche and Osborn 2003;Sariol et al 2006;Traina-Dorge et al 2005).…”

Section: Retroviruses (Simian Type D Retrovirus Simianmentioning

confidence: 99%

Impact of Infections and Normal Flora in Nonhuman Primates on Drug Development

Sasseville¹,

Diters²

2008

ILAR Journal

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Preclinical safety studies that are required for the marketing approval of a pharmaceutical include single and repeat dose studies in rodent and nonrodent species. The use of nonhuman primates (NHPs), primarily macaques, as the nonrodent species has increased in recent years, in part due to the increase in development of biopharmaceuticals and immunomodulatory agents. Depending on the source of the macaques, they may vary in genetic background, normal flora, and/or the incidence of preexisting pathogens and inflammatory conditions. As the use of alternative sources of macaques rises to meet the increased demand for these animals in biomedical research, the toxicologic pathologist should be well versed in NHP pathology to adequately assess potential drug-related effects in the context of these variations. Such knowledge is particularly important in studies involving immunomodulatory drugs as the toxicologic pathologist should anticipate which type(s) of infections are most likely to arise depending on which arm of the immune system is modulated. The purpose of this review is to discuss the immunosuppressive (e.g., simian type D retrovirus, simian immunodeficiency virus) and opportunistic viruses (e.g., cytomegalovirus, adenovirus, simian virus 40, rhesus rhadinovirus, and lymphocryptovirus), primary and opportunistic bacteria (e.g., Campylobacter spp., Shigella flexneri, Yersinia enterocolitica, Moraxella catarrhalis, Mycobacterium avium complex, enteropathogenic Escherichia coli), and parasites (e.g., Plasmodium spp., Schistosoma spp., Strongyloides fulleborni) that have had the most profound impact on the interpretation of drug safety studies and/or that may reemerge as alternative sources of NHPs are used for drug safety studies.

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“…Although SIV has been found to be relatively nonpathogenic in sooty mangabeys, 35 possibly as a result of the low levels of CCR5 on CD4+ T cells, 37 SIV sm (which gave rise to SIV mac ) induces an acquired immunodeficiency syndrome (AIDS)‐like disease in the rhesus monkey, unlike other SIV experimentally inoculated into the rhesus monkey 34 . Thus, it was discovered that captive sooty mangabey monkeys and, subsequently, wild sooty mangabey monkeys in Sierra Leone 39 carried SIV, and that the rhesus monkey was a valuable model for the study of HIV and AIDS 8,9 …”

Section: Leprosy and The Sooty Mangabey Monkeymentioning

confidence: 99%

The role of the armadillo and sooty mangabey monkey in human leprosy

et al. 2008

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Leprosy in armadillos and sooty mangabeys has been manipulated by human experimentation. In the case of the armadillo, further study, including molecular techniques, is required to elucidate the role of the armadillo as a zoonosis in human leprosy. Experimentation with the sooty mangabey led to the discovery of an interaction between SIV and leprosy in rhesus monkeys, and prompted the continued investigation of the relationship between HIV and leprosy.

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Molecular Epidemiology of Simian T-Cell Lymphotropic Virus Type 1 in Wild and Captive Sooty Mangabeys

Cited by 14 publications

References 54 publications

Overview of known non-human primate pathogens with potential to affect colonies used for toxicity testing

Overview of known non-human primate pathogens with potential to affect colonies used for toxicity testing

Impact of Infections and Normal Flora in Nonhuman Primates on Drug Development

The role of the armadillo and sooty mangabey monkey in human leprosy

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