Seroconversion for Helicobacter pylori

Kuipers, Ernst J.; Peña, A. S.; Pels, N. F. M.; Kurz-Pohlmann, E; Meuwissen, S. G. M.; Kamp, Günter; Uyterlinde, Anne M.; Pals, Gerard

doi:10.1016/0140-6736(93)91473-y

Cited by 209 publications

(135 citation statements)

References 21 publications

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“…However, until now, there have been few studies that prospectively assessed the acquisition rates in human populations (19,31). Most of the longitudinal studies have been done in populations of developed countries where the annual incidence rate has been estimated to be low: in the neighborhood of 0.3% in both children and adults (1,27). Since acquisition of H. pylori often is asymptomatic, ascertainment of symptoms does not accurately indicate when this occurs (40).…”

Section: Discussionmentioning

confidence: 99%

Transient and PersistentHelicobacter pyloriColonization in Native American Children

et al. 2003

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Helicobacter pylori is chiefly acquired in childhood, but the exact timing of acquisition is not well understood. The main goal of this study was to assess H. pylori acquisition in a pediatric population. We studied two cohorts of Native American children: a birth cohort of 50 children and 58 older children (mean age, 53 months). We measured serum immunoglobulin G (IgG), IgM, and IgA antibodies to H. pylori whole-cell antigen and IgG antibodies to CagA. Among 44 birth cohort children monitored for more than 12 months, 24 (54.5%) had seroconversions, 7 (15.9%) were transient, and 17 (38.6%) were persistent. Among the older children, 49 (84.5%) of the 58 children were monitored for 1 year; 34 (69.4%) had H. pylori antibodies at study entry. During the next year, 7 (20.6%) children seroreverted, and of 15 initially negative children, 5 (33.3%) seroconverted. In both groups, evaluation of CagA antibodies increased the sensitivity of H. pylori detection. Serum pepsinogen I (PGI) levels in H. pylori-negative children rose significantly until age 6 months and remained constant for the next 19 months. At the time of H. pylori seroconversion, PGI peaked to levels significantly higher than in the never-seroconverted (P ‫؍‬ 0.02) and the pre-seroconverted (P ‫؍‬ 0.03) children, but then declined to levels paralleling those of H. pylori-negative children. Thus, H. pylori acquisition, accompanied by a transient PGI increase, was frequent in this population, especially in the second and third years of life, but often was brief.Gastric colonization by Helicobacter pylori is highly prevalent throughout the world (3,15,41), and the organism is predominantly acquired during childhood (19,34). In developing countries, more than 80% of adults are colonized with H. pylori, and more than 50% of children become colonized before the age of 10 years compared to 30% of the adults and 10% of children in developed countries like the United States (15-17, 50, 66). With socioeconomic development, the prevalence of H. pylori has declined (26,48,50). H. pylori colonization generally persists throughout life, except in persons treated with antibiotics or those who develop atrophic gastritis, usually late in life (18,70). Although most adults have no clinical consequences of H. pylori colonization, it is a risk factor for peptic ulcer disease (7, 15, 37) and noncardia gastric adenocarcinoma (22,38). While colonization of adults with H. pylori almost always persists (26,42,48), there has been evidence for both transient and persistent colonization in children (19, 65) and in experimentally challenged nonhuman primates (12). The relative frequency of transient H. pylori acquisition among children in developing countries has been only partially characterized (29,58,65), and there is little information about gastric physiology in children in relation to H. pylori acquisition (58). An important question is whether pepsinogen production, reflecting gastric acidity (71), is affected by the H. pylori status of the child.The Native American Apache people...

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Section: Discussionmentioning

confidence: 99%

Transient and PersistentHelicobacter pyloriColonization in Native American Children

et al. 2003

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“…Esses dados são de altíssima relevância, pois estudos demonstram que o tempo de duração da infecção está diretamente relacionado ao desenvolvimento de patologias associadas, particularmente a doença ulcerativa péptica e o carcinoma gástrico. 2,15,23,31,39,47,68,75,99,104 Em relação à epidemiologia da infecção pelo H. pylori, vários conceitos estão bem estabelecidos, porém outros permanecem completamente obscuros, principalmente os relacionados à via de transmissão da bactéria. Esse fato acarreta extrema dificuldade na elaboração de normas para a prevenção da doença.…”

Section: Introductionunclassified

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

2002

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Descritores ResumoRealizou-se revisão da epidemiologia da infecção pelo Helicobacter pylori, com o objetivo de analisar sua importância na infância e adolescência no que se refere à incidência, à prevalência, às vias de transmissão e aos fatores de risco. Para tanto, realizou-se uma pesquisa nas bases de dados Lilacs (OPS/Bireme) e Medline (National Library of Medicine) e no banco de teses da Universidade de São Paulo dos anos de 1983 a 1999. A análise da literatura levou à conclusão de que a infecção pelo Helicobacter pylori é adquirida principalmente durante a infância, apresenta aumento da prevalência com a idade, os principais fatores de riscos estão relacionados ao baixo nível socioeconômico e o mecanismo de transmissão permanece desconhecido. AbstractThe scope of the review is to study the epidemiological aspects of Helicobacter pylori infection and its importance during childhood and adolescence, focusing on incidence, prevalence, transmission and risk factors. The study's references included the following databases: LILACS (PAHO/ Bireme), MEDLINE, the US's National Library of Medicine and the thesis developed at University of São Paulo for the period 1983 to 1999. It was noted that Helicobacter pylori infection is mainly acquired during childhood, age-related prevalence, main risk factors are associated to low socioeconomic status, and its transmission mechanism remains unclear.

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“…H. pylori infection almost constantly induces a specific systemic immune response which may reflect the antibodies produced at the gastric mucosal level, while only 2% of patients fail to seroconvert (276). This response was used for the diagnosis of this infection immediately following the discovery of H. pylori (236,343).…”

Section: Detection Of H Pylori Antibodiesmentioning

confidence: 99%

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

2007

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SUMMARY The discovery of Helicobacter pylori in 1982 was the starting point of a revolution concerning the concepts and management of gastroduodenal diseases. It is now well accepted that the most common stomach disease, peptic ulcer disease, is an infectious disease, and all consensus conferences agree that the causative agent, H. pylori, must be treated with antibiotics. Furthermore, the concept emerged that this bacterium could be the trigger of various malignant diseases of the stomach, and it is now a model for chronic bacterial infections causing cancer. Most of the many different techniques involved in diagnosis of H. pylori infection are performed in clinical microbiology laboratories. The aim of this article is to review the current status of these methods and their application, highlighting the important progress which has been made in the past decade. Both invasive and noninvasive techniques will be reviewed.

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Seroconversion for Helicobacter pylori

Cited by 209 publications

References 21 publications

Transient and PersistentHelicobacter pyloriColonization in Native American Children

Transient and PersistentHelicobacter pyloriColonization in Native American Children

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

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