Sero-prevalence of Anti- HCV among Yemenis Blood Donors Attending National Blood Transfusion and Research Centre in Sana'a: Yemen

Alzubiery, Tawfique KA; Alharazi, Talal; Alsumairy, Hafez; Jabir, Amar A.; Muckbil, Manal Jamil; Saleh, Majdi Abdullhabeeb; Al-Shibani, Eqtesad Abdu Ali

doi:10.9734/ibrr/2017/34731

Cited by 5 publications

(15 citation statements)

References 18 publications

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“…WHO advocates for developing national blood transfusion services based on VNR regular blood donation to ensure safe and adequate blood supply [19]. Our nding showed only 27% of blood donors are VNR that is similar to previous reported from Sana'a 27.4% [20] but contrasting the 100% VNR reported from Oman, Iran, and Qatar [21]. Such difference may re ects poor awareness and negative attitude among the Yemeni community regarding voluntary donation.…”

Section: Discussionsupporting

confidence: 80%

Prevalence and Associated Factors with Transfusion-Transmitted Infections among Blood Donors at the National Blood Transfusion and Research Center, Sana’a, Yemen

Ghaleb¹,

Alshahari

Ali

et al. 2020

Preprint

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Background: Yemen is facing major challenges in ensuring the safety and availability of blood transfusion to meet the increased demand for blood transfusion due to the protracted conflict. However, Transfusion-transmissible infectious (TTIs) agents such as hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), syphilis and malaria remain the greatest threats for blood transfusion safety in such fragile, conflict-affected and vulnerable settings. This study aimed to determine the magnitude of TTIs among blood donors attending National Blood Transfusion and Research Center (NBTRC) and its associated factors. Methods: Cross- sectional study was conducted on 340 blood donors at the NBTRC during November and December 2017. Data was collected through face-to-face interview using a predesigned questionnaire that covered socio-demographic characteristics and possible TTIs associated factors. Blood samples were drawn and tested for HBV surface antigen (HBsAg), HCV antibodies, HIV1, 2 by using electrochemi-luminescence immunoassay technique and rapid immunochromato-graphic for screened syphilis and malaria antibodies. Result: The overall prevalence of TTIs was 8.8% where 2.5 %, 1.2%, 0.3%, 1.2%, 3.2% have HBV, HCV, HIV, syphilis and malaria respectively. HBV was significantly associated with history of jaundice and cupping. Furthermore, urethero-vaginal excretion was significantly associated with syphilis while malaria was significantly higher among donors from malaria endemic areas. Nearly three-fourth of donations were from replacement donors who had significantly higher TTIs prevalence than the voluntary donors: 10.4% vs. 3.3%, OR 3.4 (CI: 1.1-11.6). Conclusions: Although the prevalence of TTIs is low, it poses a serious risk for blood recipients especially in in fragile, conflict-affected and vulnerable settings where needs for blood transfusion are increasing and resources are limited. Therefore, using more sensitive screening methods and establishment of TTIs surveillance system should be considered. Efforts should be made to improve donor recruitment procedures and increase the proportion of regular and voluntary donation.

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Section: Discussionsupporting

confidence: 80%

Prevalence and Associated Factors with Transfusion-Transmitted Infections among Blood Donors at the National Blood Transfusion and Research Center, Sana’a, Yemen

Ghaleb¹,

Alshahari

Ali

et al. 2020

Preprint

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“… 16 A low prevalence of HBsAg was reported in Iraq (0.24%), 20 Jordan (0.3%), 21 and Malaysia (0.03%). 22 The present study revealed a lower prevalence rate of HBsAg than those reported rates in Saudi Arabia (3.24%), 23 Yemen (4.1%), 14 Sudan (5.8%), 24 Nigeria (5.8%), 25 Ethiopia (3.0%), 26 Cameroon (11.2%), 27 the Central African Republic (16.7%) 28 and Mauritania (11.8%). 29 …”

Section: Discussioncontrasting

confidence: 61%

“…Previous studies revealed different results regarding viral hepatitis and HIV prevalence among blood donors. 14 , 16 It was noted that there was a discrepancy in the results, necessitating more investigation to improve and understand these variations and their impact. Hence, the purpose of this study was to update the prevalence rate of HBsAg and anti-HBc among blood donors and determine the reliability of using chemiluminescence and ELISA techniques as well as identifying the effect of duplicated or repeated blood donations on the results.…”

Section: Introductionmentioning

confidence: 99%

Updated Seroprevalence of Hepatitis B Surface Antigen and Anti-Hepatitis Core Antibody Among Blood Donors in Yemen

Alzubiery¹,

Alharazi²,

Alcantara³

et al. 2022

IDR

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Purpose Hepatitis B virus (HBV) is one of the most common infectious pathogens worldwide. Various studies found a prevalence of HBV infection among blood donors ranging from 2% to 18%. Hence, this study aimed to provide an updated prevalence of HBsAg and anti-HBcAb among blood donors. Patients and Methods This was a cross-sectional study to investigate the donation records of blood donors in Sana’a, Yemen, over one year (January to December 2019). Eligible blood donors were included in the study. The serum samples of blood donors were tested for HBsAg and anti-HBcAb (IgG & IgM) using the electrochemiluminescence (ECL) and enzyme immunoassay (EIA) techniques. Results A total of 16,367 blood donors were recruited in this study, of whom 14,300 (87.4%) donated only once during this study (single, non-duplicated blood donors), while 2067 (12.6%) were repeated or duplicated. The overall prevalence of HBsAg and anti-HBcAb was 2.4% and 10.8%, respectively. Among single non-duplicated blood donors, HBsAg and Anti-HBcAb were 2.3% and 10.6% and 3.0% and 12.5% for repeated blood donors, respectively. There were statistically significant differences between HBsAg and Anti-HBcAb in terms of donor type and testing techniques. Conclusion The seroprevalence of HBsAg and anti-HBcAb among the blood donors was 2.0% and 10.3%, respectively. The ECL technique is more sensitive, has a lower error rate, and shows an advantage over the manual EIA technique. Duplicated blood donors influence the accuracy of the seroprevalence of HBsAg and anti-HBcAb.

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“…In previous study, Al-Zubiery et al reported that, out of total 3606 blood donors, 57 donors were found to be reactive for anti-HCV, giving an overall sero-positivity of 1.6% [9], compared to (1.0%) found to be reactive for anti-HCV in the present study. The difference in the result of recent study could be related to the number of the population and using Electrochemiluminescence (ECL) technique, which is a highly innovative technology that offers distinct advantages over the other detection techniques [25].…”

Section: Discussionmentioning

confidence: 54%

“…The result of this study revealed that, (1.9%), The present study showed that, the prevalence of HBs Ag less than half of a recent study conducted in Sana'a city [10], that could be related to the number of the population selected and the technique used. This study presented that, the prevalence rate of HBs Ag was less than that has been previously reported in Sana'a City [13,14], In addition, the prevalence of HBs Ag in our study is quite similar to that reported by Acar et al [15], and Nazar et al [16] , whereas, slightly less than that reported by Al-Rubaye et al [17] , and Bashawri et al [18], who found that, (2.3%) and (2.58%) of blood donors have shown serological evidence for hepatitis B virus infection in Iraq and Saudi Arabia respectively.…”

Section: Discussionmentioning

confidence: 90%

Sero-Prevalence of HBs Ag, HCV and HIV among Blood Donors in Three Blood Bank Centers in Sana'a city: Yemen

Alzubiery

Alharazi

Alsumairy

et al. 2017

JBBS

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4Internal medicine medical specialist, Abha-Psychiatry hospital, KSA AbstractObjective: To determine the current prevalence of HBs Ag, Anti-HCV Ab and anti-HIV Ab among blood donors. Methods:This descriptive study was conducted in three blood banks centers in Sana'a city. During the study period from January to November 2016, 11374 blood donor specimens were subjected for detection anti-HBs Ag, anti-HCV and anti-HIV, by using Cobas e 411analyzer. Results:The overall prevalence of HBs Ag, HCV and HIV among blood donors was (1.9%), (1.0%) and (0.3%) respectively. Out of 11374 blood donors screened, 11249 (98.9%) were males and 125 (1.1%) were females with mean of age 30 years. While, (1.6%), (0.9) and (0.0%) of females were seropositve for HBs Ag, HCV and HIV respectively. High prevalence rate of HBs Ag and HCV found among the age group more than 55(5.7%, 2.0%) and 26-35 years old (1.9%, 1.1%) respectively. Conclusion:This study revealed less prevalence rate of HBs Ag, HCV and HIV among blood donors.

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Sero-prevalence of Anti- HCV among Yemenis Blood Donors Attending National Blood Transfusion and Research Centre in Sana'a: Yemen

Cited by 5 publications

References 18 publications

Prevalence and Associated Factors with Transfusion-Transmitted Infections among Blood Donors at the National Blood Transfusion and Research Center, Sana’a, Yemen

Prevalence and Associated Factors with Transfusion-Transmitted Infections among Blood Donors at the National Blood Transfusion and Research Center, Sana’a, Yemen

Updated Seroprevalence of Hepatitis B Surface Antigen and Anti-Hepatitis Core Antibody Among Blood Donors in Yemen

Sero-Prevalence of HBs Ag, HCV and HIV among Blood Donors in Three Blood Bank Centers in Sana'a city: Yemen

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