Sero-Prevalence and Molecular Detection of Brucellosis among Febrile Patients in West Darfur State, Sudan

Badri, Ali M; Mohamed, Sameer Ghorashi

doi:10.4172/2168-9547.1000204

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…countries. The RBT is an affordable, simple, sensitive and easiest methods to apply and the most globally used for recognizing antibodies of human brucellosis [29,30] In the work at hand, two hundred and eighty 280 (146 males and 134 female) blood samples were collected among Erbil Governorate, during the period from July 2017 to December 2017. The overall prevalence of brucella antibodies in blood from all collected human samples were 24 / 280 (8.6%), as shown in (Table 1), which is approach or slightly lower percentage with [31] in Pakistan whom found that the prevalence of Brucella infection was (9.33%) according to RBT, while [32] in Egypt reported that the prevalence of Brucella infection was (11.1%) according to RBT.…”

Section: Prevalence Of Human Brucellosis In Erbil Governorate Accordimentioning

confidence: 99%

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2018

RJLBPCS

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ABSTRACT:This study was conducted to monitoring human brucellosis among Erbil Governorate.A total of 280 blood samples were collected from male (146) and female (134). Information about persons was recorded, including sex, age, and place of habitation. These samples comprised 155 and 125 blood samples from rural and urban area respectively. The overall prevalence of brucella antibodies was (8.6%).The highest rate was found in female (9.7%), while the lowest rate was from the male (7.5 %). The prevalence rate among male was high (10.3 %) in age group 31-40 years, while in females were high (19.2%) in age group 21-30 years. Out of 280 blood samples, only (5.7%) brucella isolates were found. The isolation of Brucella abortus were (57.1%) and (66.7 %), while (42.9%) and (33.3%) were Brucella melitensis from male and female respectively. The relation between result of RBT and isolation of Brucella species achieved that (7.5 %) and (9.7%) from male and female were positive according to RBT, compared with (4.8%) and (6.7%) gave isolates of Brucella species respectively. According to the habitation of the participants, high prevalence rate (9.7%) among Rural area, whereas (7.2%) among urban area. The highest rate were found in September (12.0%), while the lowest rate were in July (6.7%).This study clarified that brucellosis is still one of a significant public health challenge for Iraqi Kurdistan. We recommend that the RBT play significant role in monitoring of human brucellosis.

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Section: Prevalence Of Human Brucellosis In Erbil Governorate Accordimentioning

confidence: 99%

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2018

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“…Human Brucellosis is a debilitating illness characterized by fever (78%), arthralgia (65%), myalgia (47%),and back pain (45%). Hepatomegaly (23%), spleenomegaly (26%) 11 . Human Brucellosis is often misdiagnosed or under diagnosed due to overlapping clinical manifestations with many other bacterial infections.…”

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confidence: 99%

Serological and Molecular Epidemiology of Human Brucellosis in Mymensingh region Bangladesh

Rasheduzzaman¹,

Hossain²,

Paul³

et al. 2020

Bangladesh J Med Microbiol

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Brucellosis is a major Bacterial Zoonotic disease worldwide. More than 500,000 new cases are reported globally every year with the annual incidence rates varying widely from <2 to >500 per 1000,000 population among different region of the world. This cross sectional descriptive study was carried out in the department of microbiology, Mymensingh medical college, Mymensingh, Bangladesh from 1st January to 31 December 2017, on total 600 patients of PUO with or without occupational exposure. Blood was taken as sample, serum was separated and screening test was done by Brucella specific latex agglutination test from all collected samples. A Titer of ≥ 1:160 was taken as positive. ICT, PCR and real time PCR were done from all screening positive samples. Among the study population 65.83% (395/600) were male and 34.17% (205/600) were female. The sero prevalence of Human Brucellosis was found 13.33% (40/300) and 5% (15/300), respectively in risk and non risk group of population. Out of 55 Brucella specific latex agglutination test positive samples 27.27% (15/55) were ICT positive, 5.45% (3/55) were PCR positive and 3.64% (2/55) were real time PCR positive. No ICT, PCR or Real time PCR cases were found from sero negative samples. Among the ICT positive cases 86.67% (13/15) from risk group and 13.33% (2/15) from non risk group of study population. Among the 3 PCR positive cases 13.33% (2/15) were from ICT positive cases and 2.5 % (1/40) from ICT negative cases. All PCR and Real time PCR positive cases were found in risk group of study population. No reliable data for Human Brucellosis is available in our country. However the present study revealed that a considerable number of Human Brucellosis is present in risk group as well as non risk group of population in both rural and urban area in Mymensingh district of Bangladesh. In our country we use only Brucella specific latex agglutination test for diagnosis of human Brucellosis. It is a non specific test and gives many false positive results. So it is necessary to introduce newer tests with higher sensitivity and specificity which will help to diagnose the disease rapidly and more accurately. Bangladesh J Med Microbiol 2020; 14 (2): 19-24

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Sero-Prevalence and Molecular Detection of Brucellosis among Febrile Patients in West Darfur State, Sudan

Cited by 2 publications

References 18 publications

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Serological and Molecular Epidemiology of Human Brucellosis in Mymensingh region Bangladesh

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