Sero epidemiological Study on Human Toxocariasis in the Rural Sector Around Recife, Northeast Brazil.

Iwanaga, Yuzuru; Gonçalves, José Felipe; Tanabe, M.; Tateno, Seiki; Tsuji, Moriyasu; Takeuchi, Tsutomu

doi:10.2149/tmh1973.21.255

Cited by 3 publications

(5 citation statements)

References 7 publications

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“…mately 40% in different study areas. [21][22][23][24]27 However, when compared with results obtained in the present study, this seems to be extremely high. The high prevalence rates could be due to the cross-reactivity of antigens used.…”

Section: Prevalence Of Toxocariasis In Northeastern Brazilcontrasting

confidence: 56%

“…7,12,[15][16][17][18] Therefore, to overcome such problems, a recombinant T. canis antigen has been developed 18 and its high specificity and usefulness have been demonstrated. 19,20 In Brazil, seroepidemiologic studies on human toxocariasis have been carried out in Recife, Pernambuco, 21,22 Butantã, São Paulo, 23,24 Vitória, Espírito Santo, 25 Campinas, Sã o Paulo, 26 and Brasilia, Distrito Federal, 27 and it has been reported that the prevalence rates of toxocariasis reached approximately 40% in some studies. [21][22][23] Here we report the prevalence rate of toxocariasis based on serologic analysis using the recombinant T. canis antigen in children in the suburb of Recife in northeastern Brazil.…”

Section: Introductionmentioning

confidence: 99%

“…19,20 In Brazil, seroepidemiologic studies on human toxocariasis have been carried out in Recife, Pernambuco, 21,22 Butantã, São Paulo, 23,24 Vitória, Espírito Santo, 25 Campinas, Sã o Paulo, 26 and Brasilia, Distrito Federal, 27 and it has been reported that the prevalence rates of toxocariasis reached approximately 40% in some studies. [21][22][23] Here we report the prevalence rate of toxocariasis based on serologic analysis using the recombinant T. canis antigen in children in the suburb of Recife in northeastern Brazil. In addition, the specificity of recombinant T. canis antigen was also evaluated using serum samples from individuals infected with Ascaris lumbricoides, which occurs commonly in subtropical and tropical areas.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Toxocariasis in Northeastern Brazil Based on Serology Using Recombinant Toxocara Canis Antigen

Coêlho¹,

Carvalho²,

Perez³

et al. 2005

The American Journal of Tropical Medicine and Hygiene

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To evaluate the prevalence of toxocariasis in children in Jaboatão dos Guararapes, Pernambuco in northeastern Brazil, 215 serum samples were examined by an enzyme-linked immunosorbent assay (ELISA) using a recombinant Toxocara canis antigen. In the ELISA, 26 (12.1%) of 215 subjects were positive. In a dot-blot assay using 53 of 215 serum samples, the diagnostic results correlated with those obtained by the ELISA. Moreover, it has been confirmed that the recombinant T. canis antigen was highly specific for toxocariasis by ELISA using serum samples positive for antibody to Ascaris lumbricoides. Considering the specificity of the recombinant antigen to toxocariasis, the ELISA or dot-blot assay using the recombinant T. canis antigen is recommended in tropical and sub-tropical regions where various parasitic infections are commonly endemic.

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Section: Prevalence Of Toxocariasis In Northeastern Brazilcontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Toxocariasis in Northeastern Brazil Based on Serology Using Recombinant Toxocara Canis Antigen

Coêlho¹,

Carvalho²,

Perez³

et al. 2005

The American Journal of Tropical Medicine and Hygiene

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“…Toxocariasis is an important helminth pathogen in developing countries 20,21 including Brazil, where the prevalence rates reach ∼40%. 22,23 Tuberculosis remains one of the leading causes of morbidity and mortality in many settings, particularly in the world's poorest countries. It is estimated that nearly 1.7 million people die each year from tuberculosis, and in 2004 approximately 8.9 million people developed the disease.…”

Section: Discussionmentioning

confidence: 99%

The Immune Response to Toxocariasis Does Not Modify Susceptibility to Mycobacterium tuberculosis Infection in BALB/c Mice

et al. 2007

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Mycobacterium tuberculosis and helminth infections coincide geographically and are classically described as TH1 and TH2 pathologies. There is much interest in exploring how concurrent worm infections might alter immune responses to mycobacterial infection. To explore this issue, mice were infected with Toxocara canis and co-infected with M. tuberculosis. Mice infected with M. tuberculosis had high numbers of neutrophils and mononuclear cells within the alveolar spaces, with increased parenchymal interferon (IFN)-gamma levels. However, in Toxocara-infected mice we detected increased eosinophil numbers in bronchoalveolar lavage fluid (BALF) and increased parenchymal levels of interleukin (IL)-5. In co-infected mice the BALF demonstrated enhanced eosinophil influx with decreased neutrophil and mononuclear cell accumulation. However, co-infected mice had similar mycobacterial proliferation in their lungs accompanied by similar histopathological changes and similar cytokine/nitric oxide production compared with Mycobacterium-only-infected mice. Our results suggest that T. canis infection does not necessarily lead to increased susceptibility to pulmonary tuberculosis.

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“…, interferon (IFN)-γ] [3] . Toxocariasis is an underestimated soil-transmitted helminthiasis that primarily affects people in developing countries [4] , [5] , including Brazil, where prevalence rates reach ∼40% [6] , [7] , while Schistosomiasis causes 14000 deaths per year, with 200–300 million infected people and 10% at risk of infection worldwide, according to the Global Burden of Disease Study [8] . Additionally, tuberculosis remains one of the leading causes of morbidity and mortality in many settings, particularly in the world's poorest countries.…”

Section: Introductionmentioning

confidence: 99%

Helminth Coinfection Does Not Affect Therapeutic Effect of a DNA Vaccine in Mice Harboring Tuberculosis

et al. 2010

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BackgroundHelminthiasis and tuberculosis (TB) coincide geographically and there is much interest in exploring how concurrent worm infections might alter immune responses against bacilli and might necessitate altered therapeutic approaches. A DNA vaccine that codifies heat shock protein Hsp65 from M. leprae (DNAhsp65) has been used in therapy during experimental tuberculosis. This study focused on the impact of the co-existence of worms and TB on the therapeutic effects of DNAhsp65.Methodology/Principal FindingsMice were infected with Toxocara canis or with Schistosoma mansoni, followed by coinfection with M. tuberculosis and treatment with DNAhsp65. While T. canis infection did not increase vulnerability to pulmonary TB, S. mansoni enhanced susceptibility to TB as shown by higher numbers of bacteria in the lungs and spleen, which was associated with an increase in Th2 and regulatory cytokines. However, in coinfected mice, the therapeutic effect of DNAhsp65 was not abrogated, as indicated by colony forming units and analysis of histopathological changes. In vitro studies indicated that Hsp65-specific IFN-γ production was correlated with vaccine-induced protection in coinfected mice. Moreover, in S. mansoni-coinfected mice, DNA treatment inhibited in vivo TGF-β and IL-10 production, which could be associated with long-term protection.Conclusions/SignificanceWe have demonstrated that the therapeutic effects of DNAhsp65 in experimental TB infection are persistent in the presence of an unrelated Th2 immune response induced by helminth infections.

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Sero epidemiological Study on Human Toxocariasis in the Rural Sector Around Recife, Northeast Brazil.

Cited by 3 publications

References 7 publications

Prevalence of Toxocariasis in Northeastern Brazil Based on Serology Using Recombinant Toxocara Canis Antigen

Prevalence of Toxocariasis in Northeastern Brazil Based on Serology Using Recombinant Toxocara Canis Antigen

The Immune Response to Toxocariasis Does Not Modify Susceptibility to Mycobacterium tuberculosis Infection in BALB/c Mice

Helminth Coinfection Does Not Affect Therapeutic Effect of a DNA Vaccine in Mice Harboring Tuberculosis

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