Sericin Alleviates Thermal Stress Induced Anxiety-Like Behavior and Cognitive Impairment Through Regulation of Oxidative Stress, Apoptosis, and Heat-Shock Protein-70 in the Hippocampus

Mahmoudi, Javad; Hosseini, Leila; Sadigh‐Eteghad, Saeed; Farajdokht, Fereshteh; Vatandoust, Seyed Mehdi; Ziaee, Mojtaba

doi:10.1007/s11064-021-03370-6

Cited by 23 publications

(9 citation statements)

References 43 publications

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“…10 Moreover, the expression of HSP70 decreased after heat stress in the hippocampus in the presence of antioxidative compounds. 36,56 According to these findings, we suggest the possibility of inhibitory effects of BHBA to the elevated HSP70 levels in the heat stress-treated mice is mediated by inhibiting the process of oxidative stress and the phosphorylation of HSF1.…”

Section: Discussionmentioning

confidence: 74%

“…However, BHBA treatment decreased p‐HSF1 and HSP70 levels in the heat stress‐treated mice. Notably, previous reports have demonstrated that heat stress can induce oxidative stress in the hippocampus 36,56 . Oxidative stress is one of the main causes for the increased expression of HSP70 57,58 .…”

Section: Discussionmentioning

confidence: 97%

“…Notably, previous reports have demonstrated that heat stress can induce oxidative stress in the hippocampus. 36,56 Oxidative stress is one of the main causes for the increased expression of HSP70. 57,58 However, as previous studies showed, BHBA exerts a protective role against oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have proved that heat stress induces impairment of cognitive functions in mice, with more time spent in the center square in OFT, 35 and less time spent in the open arms and fewer arm entries in the EPM. 36 In the OFT (Figure 3A), no differences were found among the four groups in the total distance traveled, suggesting that heat stress has no effects on locomotive activity in mice (p > .05; Figure 3B). However, heat stress-treated mice displayed cognitive dysfunctions with a great increase in the distance in the inner area (p = .0414) and time spent in the inner area (p = .0056).…”

Section: Bhba Alleviated Cognitive Dysfunctions Induced By Heat Stres...mentioning

confidence: 95%

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β‐Hydroxybutyric acid attenuates heat stress‐induced neuroinflammation via inhibiting TLR4/p38 MAPK and NF‐κB pathways in the hippocampus

Huang

Chai

et al. 2022

The FASEB Journal

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Heat stress causes many pathophysiological responses in the brain, including neuroinflammation and cognitive deficits. β‐Hydroxybutyric acid (BHBA) has been shown to have neuroprotective effects against inflammation induced by lipopolysaccharide. The aim of the present study was to evaluate the effects of BHBA on neuroinflammation induced by heat stress, as well as the underlying mechanisms. Mice were pretreated with vehicle, BHBA or minocycline (positive control group) and followed by heat exposure (43°C) for 15 min for 14 days. In mice subjected to heat stress, we found that treatment with BHBA or minocycline significantly decreased the level of serum cortisol, the expressions of heat shock protein 70 (HSP70), and the density of c‐Fos+ cells in the hippocampus. Surprisingly, the ethological tests revealed that heat stress led to cognitive dysfunctions and could be alleviated by BHBA and minocycline administration. Further investigation showed that BHBA and minocycline significantly attenuated the activation of microglia and astrocyte induced by heat stress. Pro‐inflammatory cytokines were attenuated in the hippocampus by BHBA and minocycline treatment. Importantly, compared with the heat stress group, mice in the BHBA treatment group and positive control group experienced a decrease in the expressions of toll‐like receptor 4 (TLR4), phospho‐p38 (p‐p38), and nuclear factor kappa B (NF‐κB). Our results elucidated that BHBA inhibits neuroinflammation induced by heat stress by suppressing the activation of microglia and astrocyte, and modulating TLR4/p38 MAPK and NF‐κB pathways. This study provides new evidence that BHBA is a potential strategy for protecting animals from heat stress.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Bhba Alleviated Cognitive Dysfunctions Induced By Heat Stres...mentioning

confidence: 95%

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β‐Hydroxybutyric acid attenuates heat stress‐induced neuroinflammation via inhibiting TLR4/p38 MAPK and NF‐κB pathways in the hippocampus

Huang

Chai

et al. 2022

The FASEB Journal

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“…Likewise, similar effects in differences of these factors were observed using in vitro cultured mouse neural stem cells. 12–16 These findings identified that these responses were related to the accumulation of oxidative damage and inflammation in cells following heat stress. Similarly, the expression of PKA, CREB and BDNF also changed after heat stress.…”

Section: Introductionmentioning

confidence: 94%

The combination of HT-ac and HBET improves the cognitive and learning abilities of heat-stressed mice by maintaining mitochondrial function through the PKA–CREB–BDNF pathway

Li¹,

Xu²,

Cai³

et al. 2022

Food Funct.

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Development and Application of an Advanced Biomedical Material‐Silk Sericin

Wang,

Liu,

Shi

et al. 2024

Advanced Materials

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Sericin, a protein derived from silkworm cocoons, was considered as a waste product derived from silk industry for thousands of years due to a lack of understanding of its properties. However, in recent decades, a range of exciting properties of sericin have been studied and uncovered, including cytocompatibility, low‐immunogenicity, photo‐luminescence, antioxidant properties, as well as cell‐function regulating activities. These properties make sericin‐based biomaterials promising candidates for biomedical applications. This review summarizes the properties and bioactivities of silk sericin and highlights the latest developments on sericin in tissue engineering and regenerative medicine. Furthermore, the extended application of sericin in developing flexible electronic devices and 3D bioprinting is also discussed. It is believed that sericin‐based biomaterials have great potential of being developed into novel tissue engineering products and smart implantable devices for various medical applications towards improving clinical outcomes.This article is protected by copyright. All rights reserved

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Sericin Alleviates Thermal Stress Induced Anxiety-Like Behavior and Cognitive Impairment Through Regulation of Oxidative Stress, Apoptosis, and Heat-Shock Protein-70 in the Hippocampus

Cited by 23 publications

References 43 publications

β‐Hydroxybutyric acid attenuates heat stress‐induced neuroinflammation via inhibiting TLR4/p38 MAPK and NF‐κB pathways in the hippocampus

β‐Hydroxybutyric acid attenuates heat stress‐induced neuroinflammation via inhibiting TLR4/p38 MAPK and NF‐κB pathways in the hippocampus

The combination of HT-ac and HBET improves the cognitive and learning abilities of heat-stressed mice by maintaining mitochondrial function through the PKA–CREB–BDNF pathway

Development and Application of an Advanced Biomedical Material‐Silk Sericin

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