Development and Application of an Advanced Biomedical Material‐Silk Sericin

Abstract

Sericin, a protein derived from silkworm cocoons, was considered as a waste product derived from silk industry for thousands of years due to a lack of understanding of its properties. However, in recent decades, a range of exciting properties of sericin have been studied and uncovered, including cytocompatibility, low‐immunogenicity, photo‐luminescence, antioxidant properties, as well as cell‐function regulating activities. These properties make sericin‐based biomaterials promising candidates for biomedical applications. This review summarizes the properties and bioactivities of silk sericin and highlights the latest developments on sericin in tissue engineering and regenerative medicine. Furthermore, the extended application of sericin in developing flexible electronic devices and 3D bioprinting is also discussed. It is believed that sericin‐based biomaterials have great potential of being developed into novel tissue engineering products and smart implantable devices for various medical applications towards improving clinical outcomes.This article is protected by copyright. All rights reserved

Eco-Friendly Production of Polyvinyl Alcohol/Carboxymethyl Cellulose Wound Healing Dressing Containing Sericin

“…Our results agree with the results reported by Tariq et al [ 44 ], who demonstrated the wound healing effects of sericin in diabetic mice; further studies demonstrated that sericin increased cell attachment and migration, the proliferation of keratinocytes and fibroblasts, and collagen synthesis, thus promoting wound healing in humans without the production of pro-inflammatory cytokines [ 45 , 46 , 47 , 48 , 49 ].…”

“…EpiDermFT TM tissues (EFT-412) were provided from the MatTek Corporation (Ashland, MA, USA); Dulbecco's Modified Eagle (DMEM)-based medium for maintaining cultures was supplied by the manufacturer (EFT-400-MM). Anti-Cytokeratin 14 antibody, Our results agree with the results reported by Tariq et al [44], who demonstrated the wound healing effects of sericin in diabetic mice; further studies demonstrated that sericin increased cell attachment and migration, the proliferation of keratinocytes and fibroblasts, and collagen synthesis, thus promoting wound healing in humans without the production of pro-inflammatory cytokines [45][46][47][48][49].…”

“…Therefore, in the EFT models with SER2, which contains sericin, cell migration and proliferation increased compared to the samples incubated with PVA8/CMC3.5 wound dressings and the controls (DMEM). Our results agree with the results reported by Tariq et al [44], who demonstrated the wound healing effects of sericin in diabetic mice; further studies demonstrated that sericin increased cell attachment and migration, the proliferation of keratinocytes and fibroblasts, and collagen synthesis, thus promoting wound healing in humans without the production of pro-inflammatory cytokines [45][46][47][48][49].…”

Silkworm Cocoon: Dual Functions as a Traditional Chinese Medicine and the Raw Material of Promising Biocompatible Carriers

“…Therefore, it is considered not only to be a key component of traditional medicine but also a crucial material in contemporary medical innovation. Presently, its applications primarily manifest in areas such as drug delivery systems [24][25][26], tissue engineering [27][28][29][30], and regenerative medicine [30,31]. These studies leverage the biodegradability and excellent biocompatibility of SC to develop new medical materials and treatment methods, showcasing its potential as a natural resource in the contemporary medical domain.…”