Serial MR Findings and Comprehensive Review of Bilateral Lupus Mastitis with an Additional Case Report

Mosier, Andrew; Boldt, Brian M.; Keylock, Joren; Smith, D.L.; Graham, James H.

doi:10.3941/jrcr.v7i1.1242

Cited by 12 publications

(32 citation statements)

References 11 publications

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“…Responses to corticosteroids, chloroquine, azathioprine, thalidomide, cyclophosphamide, methotrexate tetracycline, cyclosporin A, and a host of nonsteroidal medications like ibuprofen and indomethacin have been reported in some patients. [1][2][3][4]9,[14][15][16] Good results have also been reported with dapsone therapy, the mechanism being commonly attributed to a combination of antibacterial, anti-inflammatory, and immunomodulatory effects from targeting various pathways such as the bacterial synthesis of dihydrofolic acid, the migration of neutrophils, and their myeloperoxidase activity. The drug has been especially useful in patients who do not respond to other medication, including in those with associated alpha-1-antitrypsin deficiency.…”

Section: Discussionmentioning

confidence: 94%

“…However, as the calcifications increase in size and become increasingly coarse or dystrophic, they acquire a more benign appearance, and are also more easily visualized on ultrasound and MRI. [9][10][11] Our patient presented at a relatively early stage, and demonstrated no distinct course of dystrophic calcifications and a breast MRI was performed for further evaluation. Benign MRI features include high signal intensity on T1-weighted images and low signal intensity on fat-suppressed images suggesting fat, local cutaneous involvement, and continuous rim enhancement on MRI kinetic analysis instead of a wash-out curve.…”

Section: Discussionmentioning

confidence: 99%

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Nonsuppurative Nodular Panniculitis of the Breast

Rotaru

Punga

Codreanu

et al. 2015

Clinical Breast Cancer

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Nonsuppurative Nodular Panniculitis of the Breast

Rotaru

Punga

Codreanu

et al. 2015

Clinical Breast Cancer

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“…There are reports of some unusual presentation like involvement of breast, parotid gland, submandibular gland, periocular tissue and scalp as alopecia [13][14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Lupus Erythematosus Profundus: A Case Series and Review of Literature

Thapa¹,

Kubba²,

Kubba³

2018

Lupus Open Access

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Objective: Lupus Erythematosus Profundus (LEP) is a rare subset of Lupus erythematosus and clinically presents as indurated subcutaneous painful nodules and plaques. The objective of the study was to evaluate clinical, histopathological and supplementary laboratory parameters to diagnose Lupus erythematous profundus. Methods and materials:This was a retrospective study, a clinical series of histo-pathologically proven cases of 11 patients. Data were collected from clinic records from 1996 to 2010. A detailed history including onset of disease, age, sex, residence, hospital ID number and clinical examination, association with Discoid lupus erythematosus (DLE) or Systemic lupus erythematosus (SLE), laboratory workup, histopathological evaluation and Direct Immunofluorescence data was taken from the records.Result: There were total of 11 patients, with mean years of presentation of 26 years. Male to female ratio was 3:8. Face was the commonest site of distribution. Exclusively LEP presentation was seen in 83% and in 18% associated with DLE and 9% with SLE. Clinically lesions varied from nodules, indurated plaques, atrophy and ulcer. In laboratory work up ANA was positive in 9% of the cases, others baseline investigations were within normal limits. On histopathological evaluation, lobular panniculitis and hyaline fat necrosis was seen in all patients. The infiltrates were predominantly lymphohistiocytic. Direct immunofluorescence (DIF) could be done in 3 out of 11 cases. Lupus band at basement membrane zone was seen in all the 3 cases. Deposition of predominantly IgG followed by IgM, IgA and C3 were seen. Two of the three cases with positive DIF findings had no interface pathology. Conclusion:Diagnosis of LEP is based on clinico-pathological correlation. An early diagnosis and prompt treatment may help prevent disfigurement.

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“…So far, 27 cases have been reported in the literature: Kinonen and coll. reviewed 22 cases and 6 additional cases have since been reported [38][39][40][41][42][43][44].…”

Section: Lupusmentioning

confidence: 99%

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

Goulabchand

Hafidi

Perre

et al. 2020

JCM

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Mastitis frequently affects women of childbearing age. Of all the pathological breast conditions requiring specific management, autoimmune mastitis is in the third position after infection and breast cancer. The aim of this literature review was to make a comprehensive description of autoimmune diseases targeting the mammary gland. Four main histological patterns of autoimmune mastitis are described: (i) lymphocytic infiltrates; (ii) ductal ectasia; (iii) granulomatous mastitis; and (iv) vasculitis. Our literature search found that all types of autoimmune disease may target the mammary gland: organ-specific diseases (diabetes, thyroiditis); connective tissue diseases (such as systemic erythematosus lupus or Sjögren’s syndrome); vasculitides (granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, giant cell arteritis, polyarteritis nodosa, Behçet’s disease); granulomatous diseases (sarcoidosis, Crohn’s disease); and IgG4-related disease. Cases of breast-specific autoimmune diseases have also been reported, including idiopathic granulomatous mastitis. These breast-limited inflammatory diseases are sometimes the first symptom of a systemic autoimmune disease. Although autoimmune mastitis is rare, it is probably underdiagnosed or misdiagnosed. Early diagnosis may allow us to detect systemic diseases at an earlier stage, which could help to initiate a prompt, appropriate therapeutic strategy. In case of suspected autoimmune mastitis, we hereby propose a diagnostic pathway and discuss the potential pathophysiological pathways leading to autoimmune breast damage.

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Serial MR Findings and Comprehensive Review of Bilateral Lupus Mastitis with an Additional Case Report

Cited by 12 publications

References 11 publications

Nonsuppurative Nodular Panniculitis of the Breast

Nonsuppurative Nodular Panniculitis of the Breast

Lupus Erythematosus Profundus: A Case Series and Review of Literature

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

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