Serial Measurements of Higher-Order Aberrations after Blinking in Normal Subjects

Koh, Shizuka; Maeda, Naoyuki; Hirohara, Yoko; Mihashi, Toshifumi; Ninomiya, Sayuri; Bessho, Kenichiro; Watanabe, Hitoshi; Fujikado, Takashi; Tano, Yasuo

doi:10.1167/iovs.06-0018

Cited by 83 publications

(88 citation statements)

References 36 publications

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“…Several studies have investigated the influence of tear film dynamics on sequential wavefront aberrations in dry eyes and normal eyes. 26,31,32 Nowadays, wavefront sensing has been recognized as a practical objective method for evaluating sequential changes in optical quality of the eye. Thus, in the present study, we examined the sequential changes in ocular aberrations with the wavefront aberrometer to comprehend the detailed influence of eye ointment on ocular optical quality.…”

Section: Discussionmentioning

confidence: 99%

“…This system has been described in detail elsewhere. 26 Ten serial images were obtained at 1-sec intervals from 1 to 10 s following a blink. The subjects were instructed to keep their eyelids open during the image capture.…”

Section: Methodsmentioning

confidence: 99%

“…According to the study of Koh et al, 26 two quantitative indices such as fluctuation index (FI) and stability index (SI) of the total HOAs were calculated from the sequential changes in ocular aberrations over time. The FI was defined as the standard deviation of the total HOAs obtained during the serial measurements for 10 s, which reflects the fluctuations in HOAs during the measurements.…”

Section: Methodsmentioning

confidence: 99%

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Time course of changes in ocular wavefront aberration after administration of eye ointment

Hiraoka

Yamamoto²,

Okamoto

et al. 2012

Eye

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Purpose To investigate the influence of an eye ointment on ocular aberration. Design Prospective, comparative study. Methods In 10 normal volunteers, ocular aberration was assessed before and 5, 30 min, 1, 2, 3, 6, and 12 h after administration of ofloxacin eye ointment. Ocular aberration was sequentially measured over a period of 10 s, and the root mean square (RMS) of the second-, third-, fourth-, and total higher-order aberrations (HOAs) were determined. From the sequential changes in total HOAs during 10 s, the fluctuation index (FI) and stability index (SI) were calculated. The obtained data were compared with those of another 17 normal volunteers who received timolol maleate gel-forming ophthalmic solution.Results No significant changes in secondorder RMS were observed after administration of the ointment. HOAs such as third-, fourth-, and total higher-order RMS significantly changed during the study period (Po0.05, repeated-measures analysis of variance). The RMS of each HOA component significantly increased 5 min after administration compared with the baseline values (Po0.05, Dunnett test). FI also increased significantly 5 min after administration (Po0.05), but SI did not change significantly. When compared with the results of the gel-forming solution group, HOAs and FI showed significantly higher values at several time points during 6 h after application (Po0.05, Mann-Whitney U-test). Conclusions Administration of eye ointment significantly degrades optical quality of the eye by increasing and oscillating HOAs. These changes were more pronounced than those after instillation of gel-forming ophthalmic solution for at least several hours.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Time course of changes in ocular wavefront aberration after administration of eye ointment

Hiraoka

Yamamoto²,

Okamoto

et al. 2012

Eye

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“…Recently, much attention has been paid to the effect of tear film on the optical quality of the eye, and several studies have indicated that tear film break-up degrades optical quality and fluctuations in the tear film causes increased irregular astigmatism [5, 8, 31, 32]. The greater rate of evaporation at the center of palpebral aperture causes the tear film to thin more rapidly at the center than at the periphery [31].…”

Section: Discussionmentioning

confidence: 99%

“…Maintenance of a smooth, intact tear film is essential for achieving high-quality retinal images [3, 4]. Several clinical studies support the hypothesis that increased aberration as a result of a tear film disruption may reduce retinal image quality [5,6,7,8,9,10]. This fact is supported by the finding that instillation of artificial tears in dry eyes reduces the optical aberrations and increases the optical quality of the retinal images [11,12,13].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Lubricating Eye Drop Containing Hydroxypropyl Guar on Perimetry Results of Patients with Glaucoma and Trachomatous Dry Eye

Güzey¹,

Satici²,

Karaman³

et al. 2009

Ophthalmologica

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Purpose: To evaluate the effects of a mid-viscosity mucomimetic lubricant eye drop containing hydroxypropyl guar (HPG) as a gelling agent on computerized perimetry FASTPAC test results of primary open-angle glaucoma (POAG) patients with trachomatous dry eye. Methods: Both eyes of 33 patients with bilateral POAG and trachomatous dry eye were included in the study. They were treated with the same antiglaucomatous eye drop and underwent computerized perimetry. Before and after the treatment with lubricant eye drop (Systane™) for 8 weeks, tear function tests (Schirmer test with topical anesthesia, fluorescein staining and tear film break-up time) and FASTPAC test with computerized perimetry were performed. Pre- and posttreatment tear functions, visual field test global indices, reliability indices, test duration and numbers of depressed points in pattern deviation plots were compared. Results: We found significant improvements in tear function tests results, in computerized perimetry FASTPAC test indices, test duration and the number of depressed points in pattern deviation plots in the posttreatment evaluations. Conclusion: This study indicates that there was a benefit of mid-viscosity lubricant eye drop containing HPG treatment on computerized perimetry FASTPAC test performance in POAG subjects with trachomatous dry eye. We assume that the positive effect of this therapy is probably due to a better tear film stability, resulting in a higher optical quality of the repaired anterior corneal surface.

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Lokalisation und altersabhängige Verteilung von Aberrationen des Auges

2008

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Serial Measurements of Higher-Order Aberrations after Blinking in Normal Subjects

Abstract: Dynamic changes in HOAs after blinking showed variations even in clinically normal subjects. Serial measurements of HOAs may be useful in evaluating the dynamic changes in tear film and the effects on the quality of vision after blinking.

Cited by 83 publications

References 36 publications

Time course of changes in ocular wavefront aberration after administration of eye ointment

Time course of changes in ocular wavefront aberration after administration of eye ointment

The Effect of Lubricating Eye Drop Containing Hydroxypropyl Guar on Perimetry Results of Patients with Glaucoma and Trachomatous Dry Eye

Lokalisation und altersabhängige Verteilung von Aberrationen des Auges

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