Time course of changes in ocular wavefront aberration after administration of eye ointment

Abstract

Purpose To investigate the influence of an eye ointment on ocular aberration. Design Prospective, comparative study. Methods In 10 normal volunteers, ocular aberration was assessed before and 5, 30 min, 1, 2, 3, 6, and 12 h after administration of ofloxacin eye ointment. Ocular aberration was sequentially measured over a period of 10 s, and the root mean square (RMS) of the second-, third-, fourth-, and total higher-order aberrations (HOAs) were determined. From the sequential changes in total HOAs during 10 s, the fluctuation index (FI) and stability index (SI) were calculated. The obtained data were compared with those of another 17 normal volunteers who received timolol maleate gel-forming ophthalmic solution.Results No significant changes in secondorder RMS were observed after administration of the ointment. HOAs such as third-, fourth-, and total higher-order RMS significantly changed during the study period (Po0.05, repeated-measures analysis of variance). The RMS of each HOA component significantly increased 5 min after administration compared with the baseline values (Po0.05, Dunnett test). FI also increased significantly 5 min after administration (Po0.05), but SI did not change significantly. When compared with the results of the gel-forming solution group, HOAs and FI showed significantly higher values at several time points during 6 h after application (Po0.05, Mann-Whitney U-test). Conclusions Administration of eye ointment significantly degrades optical quality of the eye by increasing and oscillating HOAs. These changes were more pronounced than those after instillation of gel-forming ophthalmic solution for at least several hours.

Development and characterisation of electrospun timolol maleate-loaded polymeric contact lens coatings containing various permeation enhancers

“…Increased viscosity of formulations prolongs product residence time in the conjunctival sac; providing a more sustained release. However, an increase in viscosity can result in blurred vision; causing inconvenience to the patient (Hiraoka, et al 2012). Other approaches for extended-drug delivery involve altering the pH and the tonicity of ocular formulations, resulting in higher drug bioavailability (Gupta, et al 2010;Reddy and Ahmed 2013;Suresh and Abhishek 2016).…”

Measuring Ocular Aberrations Sequentially Using a Digital Micromirror Device

“…However, variations in the measured wavefronts are still present due the continuous involuntary movements of the eye during fixation including tremors, drifts, and microsaccades [ 19 , 20 , 21 ], where further increasing the speed would improve accuracy and repeatability. Changes in the tear film, which is known to be dynamic, may also cause changes in the measurements of ocular aberrations [ 23 ]. Binning larger amounts of pixels in the detection camera, can help improve the signal; however, compromises accuracy above 8 × 8 pixels, as seen in Figure 2 .…”

Eye

“…When the eye is injured the ointment is applied on the eyelid rim, not in the conjunctival sac. Ointments and creams are not well tolerated, because they produce a film over the eye and thereby blur vision [121]. Therefore, application in the evening is preferred.…”