Serial Measurements of Higher-Order Aberrations after Blinking in Patients with Dry Eye

Abstract

Increased HOAs in dry eye at least partially result from SPK above the optical zone. The low tear volume in dry eye may not cause sequential increases in HOAs after blinking. Sequential measurement of HOAs may be useful for evaluating the sequential changes in optical quality in patients with dry eye.

Dynamic changes in the air–tear film interface modulation transfer function

“…This correlates with previous research computing corneal [2,3] and ocular [4] wavefront aberrations, and ocular MTF [14]. This also happens in dry-eye patients with a different dynamic pattern [5][6][7][8]. Tear film dynamics has an important impact on the higher-order aberrations of the anterior cornea [2,3] and hence on those of the whole eye [3].…”

“…Montés-Micó et al [7] have found differences in the dynamic of the tear film between normal and dry eyes, measuring the change in corneal aberrations after a blink. Ocular aberrations analysis, recently performed by Koh et al [4,8], also showed dynamic variability. These changes may be attributed to the increasingly irregular tear film [5].…”

“…Since the front surface of the pre-corneal tear film is the most anterior optical surface of the eye, and the most powerful, as it is associated with the largest change in refractive index, any local change in tear film thickness and regularity will introduce additional aberrations into the eye's optical system (i.e. dry eye syndrome [5][6][7][8]). Several authors using different techniques have evaluated the dynamic of the tear film [2][3][4][5][6][7][8][9][10][11][12][13][14].…”

“…dry eye syndrome [5][6][7][8]). Several authors using different techniques have evaluated the dynamic of the tear film [2][3][4][5][6][7][8][9][10][11][12][13][14]. Montés-Micó et al [7] have found differences in the dynamic of the tear film between normal and dry eyes, measuring the change in corneal aberrations after a blink.…”

Effects of Oxidative Stress on the Conjunctiva in Cu, Zn-Superoxide Dismutase-1 (Sod1)–Knockout Mice

“…5 Tear film instability can lead to irregular astigmatism and increased higher-order aberrations, resulting in decreased visual functions. 2,6 Aging has been reported to result from deleterious damage to cells and tissues by free radicals. An imbalance between cell damage by free radicals and radical-scavenging antioxidant systems results in a condition that is called oxidative stress, which is associated with many age-related diseases and is also considered as a major factor in the process of senescence.…”