1991
DOI: 10.1046/j.1537-2995.1991.31791368345.x
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Serial immunoreactive erythropoietin levels in autologous blood donors

Abstract: The variations in plasma erythropoietin (EPO) concentration during preoperative deposit of autologous blood were studied in 12 patients (8 men, 4 women). Four donations were scheduled at weekly intervals. A predonation hemoglobin concentration of 11 g per dL (110 g/L) was required. Hemoglobin concentration decreased from 14.3 ± 1.1 g per dL (143 ± 11 g/L) (mean ± SD) before the first donation to 11.7 ± 0.7 g per dL (117 ± 7 g/L) on Day 22 (p<0.0001). Reticulocyte counts increased from a median of 31,800 (range… Show more

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Cited by 48 publications
(18 citation statements)
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“…Erythropoiesis yields approximately 2.5 blood units during the first 5 weeks (group WB) and only 1/3 of a unit during weeks 6 and 7 (group PRC/FFP). The amount of erythropoiesis during the first 5 weeks is in congruence with the results of other studies [35,36,[39][40][41][42]. Autologous predeposit as whole blood is an efficacious method to prevent homologous transfusion in hip arthroplasty [19,43].…”
Section: Discussionsupporting
confidence: 82%
See 1 more Smart Citation
“…Erythropoiesis yields approximately 2.5 blood units during the first 5 weeks (group WB) and only 1/3 of a unit during weeks 6 and 7 (group PRC/FFP). The amount of erythropoiesis during the first 5 weeks is in congruence with the results of other studies [35,36,[39][40][41][42]. Autologous predeposit as whole blood is an efficacious method to prevent homologous transfusion in hip arthroplasty [19,43].…”
Section: Discussionsupporting
confidence: 82%
“…However, the difference in decrease of the erythrocyte mass during autologous deposit is only small: on the average the decrease amounted to 109 ml in group WB and to 39 ml in group PRC/FFP. Previous studies in which 3 or 4 donations were scheduled within 3 weeks had demonstrated that reticulocyte counts reached a peak between weeks 3 and 4 and decreased thereafter [35,36], indicating that erythropoiesis is at a maximum soon after the last donation. This reflects the time course of the erythropoietin (EPO) plasma concentration after blood donation (a peak 24 h after donation, followed by a plateau at a lower level [35,36]), and the inverse exponential relation between hemotocrit and EPO [37].…”
Section: Discussionmentioning
confidence: 93%
“…40,41 Increased plasma erythropoietin levels in response to blood donation could also potentially alter endothelium-dependent vasodilation. 42,43 Finally, it is possible that some unidentified confounder associated with the altruistic behavior of frequent voluntary blood donation may account for our findings. We attempted to minimize this…”
Section: Discussionmentioning
confidence: 87%
“…Peritubular fibroblasts in the renal cortex express the EPO gene, and the number of cells in which the gene is active is inversely related to renal oxygen supply. Even moderate changes in the hemoglobin concentration, within the range of normal values, lead to a detectable increase in serum EPO levels [5].…”
mentioning
confidence: 99%