The Type of Storage of Autologous Blood Does Not Influence Homologous Transfusion Requirements in Hip Arthroplasty

Lorentz, A.; Klever, M.; Dempfle, Carl Erik; Segiet, W.

doi:10.1159/000050259

Cited by 5 publications

(4 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a randomized study on 94 patients, the storage of autologous blood as whole blood, as leukocyte-depleted whole blood or as blood components (after removal of the buffy coat) was compared [5]. In the respective groups surgery was carried out in weeks 5, 6 and 7 after first autologous donation.…”

Section: Hip Arthroplasty: the Allogenic Transfusion Ratementioning

confidence: 99%

Autologous Predeposit: To Leukocyte Deplete Or Not to Leukocyte Deplete?

Weiler-Lorentz¹,

Frietsch²

2006

Transfus Med Hemother

View full text Add to dashboard Cite

In five studies comparing different forms of storage of autologous blood the allogenic transfusion rate, humoral and cellular immune parameters and the postoperative infection rate were investigated. In a prospective, randomized study 21 volunteers donated one unit of blood. Retransfusion of stored autologous whole blood, but not of autologous packed red cells and fresh frozen plasma, induced a limited response of the immune system. Four prospective, randomized, partially or totally blinded studies investigating autologous donation in primary hip arthroplasty were carried out: In the first study including 94 patients, in which autologous blood was stored as whole blood, leukocyte-depleted whole blood or as blood components, the allogenic transfusion rates were compared. The type of storage of autologous blood did not influence homologous transfusion requirements. In a second study dealing with humoral immune factors, 97 patients were allocated at random to two groups. In one group, the autologous donation was stored as whole blood, in the other group the donation was separated into blood components before storage. With respect to the parameters studied, there were no significant differences between patients transfused with whole blood and those transfused with blood components. Moreover, these values also did not differ from those of patients not transfused. In a third study, the phagocytosis and respiratory burst activity of neutrophil granulocytes and of monocytes was measured in 58 patients who were randomly allocated to two groups as in the previous study. Neither the time course of phagocytosis nor that of respiratory burst activity showed a significant difference between both groups. In a fourth multicenter study, 953 patients were allocated to either of two groups. The first group of patients received autologous blood stored as whole blood, in the second group leukocyte depletion was done before storage. When comparing the outcomes of both groups, it could be shown that leukocyte depletion of autologous whole blood did not reduce the number of postoperative infections in primary hip surgery. It is therefore concluded that neither leukocyte depletion nor blood component separation is mandatory when using autologous predeposit in primary hip arthroplasty.

show abstract

Section: Hip Arthroplasty: the Allogenic Transfusion Ratementioning

confidence: 99%

Autologous Predeposit: To Leukocyte Deplete Or Not to Leukocyte Deplete?

Weiler-Lorentz¹,

Frietsch²

2006

Transfus Med Hemother

View full text Add to dashboard Cite

show abstract

“…The collected autologous whole blood is plasma-and leukocyte-depleted and stored as packed red blood cells (PRBC). There seems to be evidence that autologous blood, stored and re-transfused as leukocytedepleted whole blood (LD WB) has no negative impact on the patients' postoperative course [2]. In compliance with the warranted quality measures [3,4] preparation of autologous LD WB is a time-and cost-sparing procedure.…”

mentioning

confidence: 99%

Collection and Storage of Leukocyte-Depleted Whole Blood in Autologous Blood Predeposit in Elective Surgery Programs

Leitner

Rach

Horvath

et al. 2005

Transfus Med Hemother

View full text Add to dashboard Cite

“…For the majority of autologous donors no fresh frozen plasma is required during surgery or during the recovery period. The longer permissible storage period of autologous packed red cells with additive solutions does not reduce the allogenic transfusion rate in hip arthroplasty when compared with whole blood [7]. A meta-analysis comparing storage of blood as buffy coat poor packed red cells and as whole blood demonstrated little difference in terms of quality at the end of the permissible storage period; in particular, no difference in the 24-h survival rate of the erythrocytes [8].…”

mentioning

confidence: 99%