Serial Free Bisphenol A and Bisphenol A Glucuronide Concentrations in Neonates

Nachman, Rebecca; Fox, Stephen D.; Golden, William; Sibinga, Erica; Groopman, John D.; Lees, Peter S.J.

doi:10.1016/j.jpeds.2015.03.036

Cited by 18 publications

(12 citation statements)

References 38 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Analysis of urine samples from a cohort of healthy full term (≥37 weeks' gestation) neonates at two intervals of age (3-6 and 7-27 days) shows that only the inactive BPA glucuronide (BPAG), but not the free BPA form, is detected with concentrations ranging from <0.1 µg/L to 11.21 µg/L (median: 0.27 µg/L). These results confirm widespread BPA exposure in healthy full-term neonates, and efficient conjugation of BPA to its readily excretable and biologically inactive BPAG as early as 3 days of age (81). However, some studies suggest that cycling of conjugation/deconjugation maintains low but sustained basal levels of free BPA in the fetus (82).…”

Section: Human Environmental Exposuressupporting

confidence: 52%

Bisphenols and Risk of Breast Cancer: A Narrative Review of the Impact of Diet and Bioactive Food Components

et al. 2020

View full text Add to dashboard Cite

Data from preclinical studies suggest a link between increased risk of breast cancer and exposure to bisphenols at doses below what the United States Food and Drug Administration (FDA) considers as safe for consumption. Bisphenols exert estrogenic effects and are found in canned and plastic wrapped foods, food packaging, and plasticware. Mechanistically, bisphenols bind to the estrogen receptor (ER) and activate the expression of genes associated with cell proliferation and breast cancer. In this paper, we present a narrative literature review addressing bisphenol A and chemical analogs including bisphenol AF, bisphenol F, and bisphenol S selected as prototype xenoestrogens; then, we discuss biological mechanisms of action of these bisphenols in breast cells and potential impact of exposure at different stages of development (i.e., perinatal, peripubertal, and adult). Finally, we summarize studies detailing interactions, both preventative and promoting, of bisphenols with food components on breast cancer risk. We conclude the review with a discussion of current controversies in interpretation of the above research and future areas for investigation, including the impact of bisphenols and food components on breast tumor risk.

show abstract

Section: Human Environmental Exposuressupporting

confidence: 52%

Bisphenols and Risk of Breast Cancer: A Narrative Review of the Impact of Diet and Bioactive Food Components

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Human exposure is nearly universal in developed countries and occurs mainly through contaminated beverages and food 3 . Several studies indicate widespread contamination of fetuses and neonates, leading to the questions as to whether such an EDC can affect development [4][5][6] and whether there is a limit for a safe exposure. Currently, the US Environmental Protection Agency (EPA) "safety level" of BPA is set at 50 μg/kg/d i.e.…”

Section: Introductionmentioning

confidence: 99%

Persistent vs transient alteration of folliculogenesis and estrous cycle after neonatal vs adult exposure to Bisphenol A

et al. 2019

View full text Add to dashboard Cite

Exposure to Bisphenol A (BPA), a ubiquitous endocrine disrupting chemical (EDC) is known to produce variable effects on female puberty and ovulation. This variability of effects is possibly due to differences in dose and period of exposure. Little is known about the effects of adult exposure to environmentally relevant doses of this EDC and the differences in effect after neonatal exposure. This study aims at comparing the effects of neonatal versus adult exposure to a very low or a high dose of BPA for two weeks on ovulation and folliculogenesis and exploring the hypothalamic mechanisms involved in such disruption by BPA. One day-old and 90 day-old female rats received daily subcutaneous injections of corn oil (vehicle) or BPA (25 ng/kg/d or 5 mg/kg/d) for 15 days. Neonatal exposure to both BPA doses significantly disrupted the estrous cycle and induced a decrease in primordial follicles. Effects on estrous cyclicity and folliculogenesis persisted into adulthood, consistent with a disruption of organizational mechanisms. During adult exposure, both doses caused a reversible decrease in antral follicles and corpora lutea. A reversible disruption of the estrous cycle associated with a delay and a decrease in the amplitude of the LH surge was also observed. Alterations of the hypothalamic expression of the clock gene Per1 and the novel reproductive peptide Phoenixin indicated a disruption of the hypothalamic control of the preovulatory LH surge by BPA.

show abstract

“…15 A growing number of studies have reported urinary concentrations of BPA in children worldwide, ranging in ages from infancy to early adolescence (Table S1, Supplement). [3][4][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Many of these studies have considered the effects of sociodemographic factors, such as parental education and household income, on childhood urinary BPA concentrations, while only a few have explored associations with dietary sources of BPA exposure. 20,21,25 Additional studies are needed to identify other potentially modifiable sources of BPA exposure.…”

Section: Introductionmentioning

confidence: 99%

Patterns, Variability, and Predictors of Urinary Bisphenol A Concentrations during Childhood

Stacy¹,

Eliot²,

Calafat³

et al. 2016

ISEE Conference Abstracts

View full text Add to dashboard Cite

Dr. Lanphear has served as an expert witness and a consultant to the California Attorney General's Office for the plaintiffs in a public nuisance case related to childhood lead poisoning, but he has not personally received any compensation for these services. Dr. Lanphear has also served as a paid consultant on a US Environmental Protection Agency research study related to childhood lead poisoning. Dr. Braun was financially compensated for conducting a re-analysis of a study of child lead exposure for the plaintiffs in a public nuisance case related to childhood lead poisoning. None of these activities are directly related to the present study. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Conflicts of Interest: The authors have no actual or potential competing financial interests. Supporting Information Includes additional information on equations for calculating creatinine excretion rates, distributions of urinary BPA and creatinine concentrations in the HOME study, and estimated BPA daily intakes

show abstract

Serial Free Bisphenol A and Bisphenol A Glucuronide Concentrations in Neonates

Cited by 18 publications

References 38 publications

Bisphenols and Risk of Breast Cancer: A Narrative Review of the Impact of Diet and Bioactive Food Components

Bisphenols and Risk of Breast Cancer: A Narrative Review of the Impact of Diet and Bioactive Food Components

Persistent vs transient alteration of folliculogenesis and estrous cycle after neonatal vs adult exposure to Bisphenol A

Patterns, Variability, and Predictors of Urinary Bisphenol A Concentrations during Childhood

Contact Info

Product

Resources

About