Patterns, Variability, and Predictors of Urinary Bisphenol A Concentrations during Childhood

Abstract

Dr. Lanphear has served as an expert witness and a consultant to the California Attorney General's Office for the plaintiffs in a public nuisance case related to childhood lead poisoning, but he has not personally received any compensation for these services. Dr. Lanphear has also served as a paid consultant on a US Environmental Protection Agency research study related to childhood lead poisoning. Dr. Braun was financially compensated for conducting a re-analysis of a study of child lead exposure for the plaintiffs in a public nuisance case related to childhood lead poisoning. None of these activities are directly related to the present study. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Conflicts of Interest: The authors have no actual or potential competing financial interests. Supporting Information Includes additional information on equations for calculating creatinine excretion rates, distributions of urinary BPA and creatinine concentrations in the HOME study, and estimated BPA daily intakes

Short-term variability of bisphenols in spot, morning void and 24-hour urine samples

“…0.70 for 24 h timespan, 0.51 for two days, indicating that within-person variability increases as larger timespans are considered (Lassen et al, 2013;Heffernan et al, 2014;Sakhi et al, 2018). Several studies that also compared different dilution correction methods, reported results similar to our study, namely that SG corrected concentrations yielded lower ICCs compared to CRT corrected levels (Philippat et al, 2013;Koch et al, 2014;Stacy et al, 2016;Morgan et al, 2018;Vernet et al, 2018). However, contradictory results, showing that using CRT corrected concentrations lowers the ICCs, have also been reported for BPA (Braun et al, 2011;Ye et al, 2011;Guidry et al, 2015;Vernet et al, 2018).…”

Patterns, Variability, and Predictors of Urinary Triclosan Concentrations during Pregnancy and Childhood

“…Nevertheless, as indicated by the short-term ICCs in our study, triclosan concentrations have better reproducibility compared to other nonpersistent chemicals, such as bisphenol A. 39 Our analysis of short-term ICCs suggests that triclosan exposure may be relatively stable over a period of a few weeks, and, thus, a single sample may be adequate to assess exposure at distinct and defined life-stages. Future epidemiology studies might consider collecting, and possibly pooling, multiple urine samples over a period of weeks or months at each age from pregnant women or children to minimize exposure misclassification for that lifestage.…”

Associations of mid-childhood bisphenol A and bisphenol S exposure with mid-childhood and adolescent obesity

“…We selected covariates potentially associated with BPA/BPS exposure and adiposity using a directed acyclic graph and prior knowledge 28,29 (Figure S3; http://links.lww.com/EE/A170). Though covariates such as child sex, physical activity, and maternal BMI are not associated with urinary BPA and BPS concentrations, we adjusted for them to reduce residual error and improve the precision of estimates.…”