Associations of mid-childhood bisphenol A and bisphenol S exposure with mid-childhood and adolescent obesity

Gajjar, Priya; Liu, Yun; Li, Nan; Buckley, Jessie P.; Chen, Aimin; Lanphear, Bruce P.; Kalkwarf, Heidi J.; Cecil, Kim M.; Yolton, Kimberly; Braun, Joseph M.

doi:10.1097/ee9.0000000000000187

Cited by 14 publications

(10 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, in a Korean cross-sectional study, including more than 3000 adults aged 19 years or older from the Korean National Environmental Health Survey 2015–2017 [ 34 ], BPS exposure (MUC, 0.03 µg·L −1 ) showed a more significant association with developing obesity in males than females. Although conflicting results were reported by Gajjar et al [ 33 ], increased waist circumference at 8 years due to exposure to BPS mostly emerged in girls but not boys. In another study, elevated BMI levels were only observed in females consuming food highly exposed to total BPs [ 19 ].…”

Section: Urinary Concentrations Of Bps/bpf and The Incidence Of Obesi...mentioning

confidence: 82%

“…Interestingly, BPA exposure in this sample did not show such results. In another US sample, including only children from the Health Outcomes and Measures of the Environment (HOME) follow-up cohort [ 33 ], exposure to BPS (MUC, 0.4 µg·L −1 ) at the age of 8 years had no significant relation to developing general obesity at the age of 8 and 12 years. However, results showed that exposure to BPS was positively associated with an increase in waist circumference at age 8.…”

Section: Urinary Concentrations Of Bps/bpf and The Incidence Of Obesi...mentioning

confidence: 99%

See 1 more Smart Citation

Exposure to Bisphenol A Substitutes, Bisphenol S and Bisphenol F, and Its Association with Developing Obesity and Diabetes Mellitus: A Narrative Review

Alharbi

Algonaiman

Alduwayghiri

et al. 2022

IJERPH

View full text Add to dashboard Cite

Bisphenol A, a well-known endocrine-disrupting chemical, has been replaced with its analogs bisphenol S (BPS) and bisphenol F (BPF) over the last decade due to health concerns. BPS and BPF are present in relatively high concentrations in different products, such as food products, personal care products, and sales receipts. Both BPS and BPF have similar structural and chemical properties to BPA; therefore, considerable scientific efforts have investigated the safety of their exposure. In this review, we summarize the findings of relevant epidemiological studies investigating the association between urinary concentrations of BPS and/or BPF with the incidence of obesity or diabetes. The results showed that BPS and BPF were detected in many urinary samples at median concentrations ranging from 0.03 to 0.4 µg·L−1. At this exposure level, BPS median urinary concentrations (0.4 µg·L−1) were associated with the development of obesity. At a lower exposure level (0.1–0.03 µg·L−1), two studies showed an association with developing diabetes. For BPF exposure, only one study showed an association with obesity. However, most of the reported studies only assessed BPS exposure levels. Furthermore, we also summarize the findings of experimental studies in vivo and in vitro regarding our aim; results support the possible obesogenic effects/metabolic disorders mediated by BPS and/or BPF exposure. Unexpectedly, BPS may promote worse obesogenic effects than BPA. In addition, the possible mode of action underlying the obesogenic effects of BPS might be attributed to various pathophysiological mechanisms, including estrogenic or androgenic activities, alterations in the gene expression of critical adipogenesis-related markers, and induction of oxidative stress and an inflammatory state. Furthermore, susceptibility to the adverse effects of BPS may be altered by sex differences according to the results of both epidemiological and experimental studies. However, the possible mode of action underlying these sex differences is still unclear. In conclusion, exposure to BPS or BPF may promote the development of obesity and diabetes. Future approaches are highly needed to assess the safety of BPS and BPF regarding their potential effects in promoting metabolic disturbances. Other studies in different populations and settings are highly suggested.

show abstract

Section: Urinary Concentrations Of Bps/bpf and The Incidence Of Obesi...mentioning

confidence: 82%

Section: Urinary Concentrations Of Bps/bpf and The Incidence Of Obesi...mentioning

confidence: 99%

Exposure to Bisphenol A Substitutes, Bisphenol S and Bisphenol F, and Its Association with Developing Obesity and Diabetes Mellitus: A Narrative Review

Alharbi

Algonaiman

Alduwayghiri

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…However, Gajjar et al. reported conflicting results, did not find compelling evidence that child sex modified the association between urinary BPA concentrations and adiposity outcomes at 8 years of age ( 36 ). Additionally, a longitudinal cohort study conducted in California reported that prenatal urinary BPA concentrations were associated with reduced BMI in females at 9 years of age, but not in males ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

Association between Bisphenol A exposure and body composition parameters in children

et al. 2023

View full text Add to dashboard Cite

BackgroundAlthough there is evidence linking Bisphenol A (BPA) exposure to obesity, research examining its relationship with body composition parameters in young children is limited.MethodsA cross-sectional investigation was conducted on 200 preschool children aged between 4 and 6 years in Guangzhou, China. BPA exposure was assessed through urine samples using ultra-high performance liquid chromatography- tandem mass spectrometry, and body composition parameters were measured through bioelectrical impedance analysis (InBody770).ResultsThe median urinary BPA concentration was 0.556 μg/L (IQR: 0.301 - 1.031 μg/L) and creatinine-adjusted BPA concentration was 0.930 μg/g (IQR: 0.551 - 1.586 μg/g). BPA levels were significantly associated with body mass index (β= 1.15; 95%CI: 0.47, 1.83), body fat mass (β= 1.14; 95%CI: 0.39, 1.89), fat free mass (β= 0.92; 95%CI: 0.26, 1.58), and percent body fat (β= 3.44; 95%CI: 1.17, 5.71) after adjusting for potential confounding factors. Similarly, adjusted models with log10-transformed creatinine-adjusted BPA concentrations as a continuous variable showed similar trends. Positive linear associations were observed between quartiles of BPA concentrations and body composition parameters, with the highest coefficients in the fourth quartile.ConclusionOur study provides further evidence of positive correlations between BPA exposure and body composition parameters in children aged 4 to 6 years. These findings highlight the potential health risks associated with obesity-related body composition parameters in young children. Further investigations are needed to confirm this association and explore the underlying mechanisms.

show abstract

“…This observation is further strengthened by the findings of longitudinal studies [ 190 , 192 ] demonstrating accelerated weight gain and higher incidence of central obesity among individuals with higher urinary or serum BPA concentrations [ 181 ]. The findings regarding this relationship are not equivocal, since other studies with similar methodologies have failed to demonstrate any substantial associations [ 183 , 187 ]; however, existing meta-analyses of the available clinical studies point towards a consistent association of higher BPA measurements with the prevalence of overweight and generalized or central obesity [ 178 , 185 , 186 ], while one study has demonstrated the presence of an inverse U-shaped dose–effect relationship between serum BPA and incident overweight/obesity in individuals with normal weight [ 181 ]. Similar associations have also been found between BPA and childhood/adolescent obesity [ 179 , 184 , 187 , 188 , 193 , 195 ] and are additionally supported by relevant meta-analyses [ 215 ] despite the presence of studies with neutral results [ 183 ].…”

Section: Evidence From Human Studies Linking Bpa and Phthalates To Ob...mentioning

confidence: 98%

The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity: Current Evidence, Perspectives and Controversies

Dalamaga,

Kounatidis,

Tsilingiris

et al. 2024

IJMS

View full text Add to dashboard Cite

Excess body weight constitutes one of the major health challenges for societies and healthcare systems worldwide. Besides the type of diet, calorie intake and the lack of physical exercise, recent data have highlighted a possible association between endocrine-disrupting chemicals (EDCs), such as bisphenol A, phthalates and their analogs, and obesity. EDCs represent a heterogeneous group of chemicals that may influence the hormonal regulation of body mass and adipose tissue morphology. Based on the available data from mechanistic, animal and epidemiological studies including meta-analyses, the weight of evidence points towards the contribution of EDCs to the development of obesity, associated disorders and obesity-related adipose tissue dysfunction by (1) impacting adipogenesis; (2) modulating epigenetic pathways during development, enhancing susceptibility to obesity; (3) influencing neuroendocrine signals responsible for appetite and satiety; (4) promoting a proinflammatory milieu in adipose tissue and inducing a state of chronic subclinical inflammation; (5) dysregulating gut microbiome and immune homeostasis; and (6) inducing dysfunction in thermogenic adipose tissue. Critical periods of exposure to obesogenic EDCs are the prenatal, neonatal, pubertal and reproductive periods. Interestingly, EDCs even at low doses may promote epigenetic transgenerational inheritance of adult obesity in subsequent generations. The aim of this review is to summarize the available evidence on the role of obesogenic EDCs, specifically BPA and phthalate plasticizers, in the development of obesity, taking into account in vitro, animal and epidemiologic studies; discuss mechanisms linking EDCs to obesity; analyze the effects of EDCs on obesity in critical chronic periods of exposure; and present interesting perspectives, challenges and preventive measures in this research area.

show abstract

Associations of mid-childhood bisphenol A and bisphenol S exposure with mid-childhood and adolescent obesity

Abstract: J.M.B. served as an expert witness in litigation related to perfluorooctanoic acid contamination in drinking water in New Hampshire. Any funds he received from this arrangement were/are paid to Brown University and cannot be used for his direct benefit (e.g., salary/fringe, travel, etc.

Cited by 14 publications

References 47 publications

Exposure to Bisphenol A Substitutes, Bisphenol S and Bisphenol F, and Its Association with Developing Obesity and Diabetes Mellitus: A Narrative Review

Exposure to Bisphenol A Substitutes, Bisphenol S and Bisphenol F, and Its Association with Developing Obesity and Diabetes Mellitus: A Narrative Review

Association between Bisphenol A exposure and body composition parameters in children

The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity: Current Evidence, Perspectives and Controversies

Contact Info

Product

Resources

About