Serial analysis of regional left ventricular wall motion by two-dimensional echocardiography in patients with coronary artery enlargement after Kawasaki disease

Vogel, Michael; Smallhorn, Jeffrey F.; Freedom, Robert M.

doi:10.1016/0735-1097(92)90193-q

Cited by 6 publications

(2 citation statements)

References 18 publications

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“…Myocarditis is a well-recognized component of KD, with left ventricular systolic dysfunction occurring in 50-70% of patients during the acute stage [1][2][3][4][5][6][7][8][9][10]. Abnormalities of left ventricular contractility and systolic function have been documented to resolve within 12 months of onset of KD, with rapid improvement after the administration of intravenous immunoglobulin (IVIG) [1][2][3].…”

Section: Introductionmentioning

confidence: 97%

Diastolic function in children with Kawasaki Disease

Tierney¹,

Baker²,

Fulton³

et al. 2011

International Journal of Cardiology

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Section: Introductionmentioning

confidence: 97%

Diastolic function in children with Kawasaki Disease

Tierney¹,

Baker²,

Fulton³

et al. 2011

International Journal of Cardiology

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“…KD is now the leading source of acquired heart disease in children [17,28]. Prior studies have clearly identified the presence of myocardial involvement in the acute phase of KD, specifically myocarditis that has been shown to be associated with subclinical and clinical left ventricular dysfunction [2,9,11,12,14,16,18,27]. Standard therapy for patients with acute KD is treatment with intravenous immune globulin (IVIG) which reduces the risk of CAL from 25 to 5 % [19].…”

Section: Introductionmentioning

confidence: 98%

Tissue Doppler Imaging as a Predictor of Immunoglobulin Resistance in Kawasaki Disease

et al. 2015

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Kawasaki disease (KD) is characterized by myocarditis and left ventricular dysfunction during the acute phase of the illness. Despite treatment with intravenous immunoglobulin (IVIG), a significant number of patients are IVIG resistant. We evaluated KD patients in the acute phase of illness using tissue Doppler imaging (TDI) to assess whether myocardial dysfunction may predict IVIG resistance. All patients with acute KD presenting to Children's Hospital Colorado from February 2007 through March 2014 were included in this study and underwent echocardiograms with TDI evaluation at diagnosis. Patients were divided into two groups: IVIG resistant and IVIG responder. Group differences were assessed using Wilcoxon-Mann-Whitney and Chi-square testing. Receiver operating characteristic (ROC) curve analysis was utilized to determine threshold values of TDI measurements associated with IVIG resistance. Fifty-one age-matched IVIG resistant patients were compared to 51 IVIG responder patients [median age, IQR 44.57 (20.13-77.07) vs. 33.49 (17.30-62.89) months, p < 0.44]. There were significant differences in the septal and mitral early diastolic velocities (E') (p < 0.001 and p < 0.01), respectively. ROC analysis demonstrated that tricuspid E' <0.15 cm/s, septal E' <0.12 cm/s, and mitral E' <0.16 cm/s were good predictors of IVIG unresponsiveness (AUC = 0.66, 0.66, and 0.70, respectively). There were no differences between the systolic velocities and late diastolic velocities (A'). IVIG resistant KD patients present with significantly greater diastolic dysfunction compared to responders in patients with KD. TDI may be a useful tool to differentiate KD patients at higher risk of IVIG resistance.

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Imaging and Functional Assessment by Novel Echocardiographic Techniques

Vogel¹

2010

Paediatric Cardiology

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Serial analysis of regional left ventricular wall motion by two-dimensional echocardiography in patients with coronary artery enlargement after Kawasaki disease

Abstract: These early changes are most likely secondary to associated myocarditis rather than coronary artery abnormalities.

Cited by 6 publications

References 18 publications

Diastolic function in children with Kawasaki Disease

Diastolic function in children with Kawasaki Disease

Tissue Doppler Imaging as a Predictor of Immunoglobulin Resistance in Kawasaki Disease

Imaging and Functional Assessment by Novel Echocardiographic Techniques

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