Sequential use of photodynamic therapy and imiquimod 5% cream for the treatment of actinic cheilitis: a 12‐month follow‐up study

Sotiriou, Eleni; Lallas, Aimilios; Goussi, C.; Apalla, Zoe; Trigoni, Anastasia; Chovarda, E.; Ioannides, Demetris

doi:10.1111/j.1365-2133.2011.10478.x

Cited by 39 publications

(53 citation statements)

References 23 publications

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“…42 A number of studies noted that subjects received no treatments in the 2 to 3 months before their baseline evaluation. A number of studies reported subjects with no previous treatments, 40-43 but most subjects had attempted 1 or more of the following: lubricants, emollients, topical 5-FU, imiquimod, diclofenac, retinoids, electrodessication, cryosurgery, and erbium-doped yttrium aluminum garnet laser.…”

Section: Previous Treatmentsmentioning

confidence: 99%

“…42 Imiquimod was applied over the entire lower lip once a day, 3 days a week over 4 weeks. 42 Imiquimod was applied over the entire lower lip once a day, 3 days a week over 4 weeks.…”

Section: Treatment Protocolsmentioning

confidence: 99%

“…46,48,49 Most studies reported an incubation period of 2 to 4 hours under occlusion, with 3 hours most commonly reported. 14,41,42,48,50 Studies using MAL and red light most commonly reported a treatment dose of 37 J/cm 2 with a range of 37 to 80 J/cm 2 , irradiances ranging from 70 to 192 100 mW/cm 2 for treatment periods of 7 to 12 minutes at a distance of 5 to 7 cm (Table 1). 37 Several studies examined lesions under fluorescent light to ensure absorption of the photosensitizing cream before irradiation.…”

Section: Treatment Techniquesmentioning

confidence: 99%

“…The study of ALA and blue light reported incubation periods of 1 to 1.5 hours, 45 whereas the study of MAL and daylight reported no incubation at all. 40,42,43,[46][47][48][49] When MAL was used with daylight, subjects were simply exposed to daylight for 2.5 hours after application of MAL. 14,41,42,48,50 Studies using MAL and red light most commonly reported a treatment dose of 37 J/cm 2 with a range of 37 to 80 J/cm 2 , irradiances ranging from 70 to 192 100 mW/cm 2 for treatment periods of 7 to 12 minutes at a distance of 5 to 7 cm (Table 1).…”

Section: Treatment Techniquesmentioning

confidence: 99%

“…In studies with 10 or more subjects, the mean CR rate was 60.25% (62.5% and 58% with MAL and ALA, respectively). 41,42 In 1 study of 16 subjects treated with blue light-activated ALA-PDT, the CR rate was 19% at 3 months, but all subjects were reported to have more than 75% clearance of lesions. 41,42 In 1 study of 16 subjects treated with blue light-activated ALA-PDT, the CR rate was 19% at 3 months, but all subjects were reported to have more than 75% clearance of lesions.…”

Section: Clinical Histological and Cosmetic Outcomesmentioning

confidence: 99%

See 4 more Smart Citations

Photodynamic Therapy for Actinic Cheilitis

Abyaneh

Falto‐Aizpurua

Griffith

et al. 2015

Dermatologic Surgery

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Section: Previous Treatmentsmentioning

confidence: 99%

“…42 Imiquimod was applied over the entire lower lip once a day, 3 days a week over 4 weeks. 42 Imiquimod was applied over the entire lower lip once a day, 3 days a week over 4 weeks.…”

Section: Treatment Protocolsmentioning

confidence: 99%

Section: Treatment Techniquesmentioning

confidence: 99%

Section: Treatment Techniquesmentioning

confidence: 99%

Section: Clinical Histological and Cosmetic Outcomesmentioning

confidence: 99%

See 3 more Smart Citations

Photodynamic Therapy for Actinic Cheilitis

Abyaneh

Falto‐Aizpurua

Griffith

et al. 2015

Dermatologic Surgery

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Principles of Photodynamic Therapy

Ibbotson

McKenna

2016

Rook's Textbook of Dermatology, Ninth Edition

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Topical photodynamic therapy is widely used for the treatment of superficial non‐melanoma skin cancer and dysplasia and has been shown to be at least as effective as non‐surgical standard comparators such as topical fluorouracil and cryotherapy. British and European guidelines are available for its use, and treatment is undertaken on an out‐patient basis and is generally well tolerated, with the exception of pain during irradiation in a significant proportion of patients. Optimization of treatment regimens to improve efficacy and reduce side effects have included refinements in pro‐drug development and delivery and in the methods of light delivery, in particular using reduced irradiance regimens. The use of topical photodynamic therapy (PDT) has also been applied to a wide range of other diverse skin diseases including acne vulgaris and recalcitrant viral warts and it may have a role in some of these conditions, although further studies are required. It is important that topical PDT services are widely available in dermatology, particularly to those involved in skin cancer management, through the multidisciplinary team, and that standards and clinical governance for PDT are established.

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Dermatoses of the Oral Cavity and Lips

Scully¹

2016

Rook's Textbook of Dermatology, Ninth Edition

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Oral and labial lesions are usually the result of local disease but may be the early signs of systemic disease, including dermatological disorders, and in some instances may cause the main symptoms. This chapter mainly discusses disorders of the periodontal and mucosal tissues that may be related to skin disease and that may present at a dermatology clinic. It should be borne in mind that the professionals most competent in diagnosing and treating oral diseases are those with formal dental training and who are therefore in a position to understand the full complexities of the region. This chapter is divided into a brief discussion of the biology of the mouth, an overview of the more common signs and symptoms affecting specific oral tissues, discussion of the disorders of the oral mucosa of most relevance to dermatology and a tabulated review of oral manifestations of systemic diseases. Only the more classic oral lesions are illustrated. For reasons of space restrictions, diseases affecting the teeth, salivary glands, jaws or temporomandibular joints are not discussed in any depth.

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Sequential use of photodynamic therapy and imiquimod 5% cream for the treatment of actinic cheilitis: a 12‐month follow‐up study

Abstract: Sequential use of PDT and imiquimod cream is of significant benefit for the treatment of AC. Further studies are needed in order to confirm the improved outcome using the combination treatment, to clarify the involved mechanisms and to optimize the therapeutic protocol.

Cited by 39 publications

References 23 publications

Photodynamic Therapy for Actinic Cheilitis

Photodynamic Therapy for Actinic Cheilitis

Principles of Photodynamic Therapy

Dermatoses of the Oral Cavity and Lips

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