Sequential Treatment with Triple Combination Cream and Intense Pulsed Light is More Efficacious than Sequential Treatment with an Inactive (Control) Cream and Intense Pulsed Light in Patients with Moderate to Severe Melasma

Goldman, Mitchel P.; Gold, Michael H.; Palm, Melanie D.; Colón, Luz E; Preston, Norman; Johnson, Lori A.; Gottschalk, Ronald W

doi:10.1111/j.1524-4725.2010.01849.x

Cited by 46 publications

(50 citation statements)

References 31 publications

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“…The TCC contained 4% hydroquinone, 0.05% tretinoin, and 0.01% fluocinolone acetonide. At week 10, 57% of patients in the IPL with TCC group were clear or almost clear in contrast to 23% of patients in the IPL with PC group (Goldman et al, 2011). A similar finding was reported by Figueiredo and Trancoso (2012) who compared outcomes of patients treated with IPL and TCC versus TCC therapy alone.…”

Section: Overview Of Laser- and Light-based Treatment Optionsmentioning

confidence: 86%

A review of laser and light therapy in melasma

Trivedi

Yang

Cho³

2017

International Journal of Women's Dermatology

133

135

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Melasma is a dysregulation of the homeostatic mechanisms that control skin pigmentation and excess pigment is produced. Traditional treatment approaches with topical medications and chemical peels are commonly used but due to the refractory and recurrent nature of melasma, patients often seek alternative treatment strategies such as laser and light therapy. Several types of laser and light therapy have been studied in the treatment of melasma. Intense pulsed light, low fluence Q-switched lasers, and non-ablative fractionated lasers are the most common lasers and light treatments that are currently performed. They all appear effective but there is a high level of recurrence with time and some techniques are associated with an increased risk for postinflammatory hyper- or hypopigmentation. The number and frequency of treatments varies by device type but overall, Q-switched lasers require the greatest number of treatment applications to see a benefit. Vascular-specific lasers do not appear to be effective for the treatment of melasma. Ablative fractionated lasers should be used with caution because they have a very high risk for postinflammatory hypo- and hyperpigmentation. The use of nonablative fractionated laser treatments compared with other laser and light options may result in slightly longer remission intervals. Picosecond lasers, fractional radiofrequency, and laser-assisted drug delivery are promising future approaches to treat melasma. The goal of this review is to summarize the efficacy and safety of the most commonly used laser and light therapies to treat melasma, briefly present future laser-based treatment options for patients with melasma, and provide recommendations for treatment on the basis of the reviewed information.

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Section: Overview Of Laser- and Light-based Treatment Optionsmentioning

confidence: 86%

A review of laser and light therapy in melasma

Trivedi

Yang

Cho³

2017

International Journal of Women's Dermatology

133

135

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“…IPL uses high fluence of pulsed light and this high fluence of light carries higher risk of rebound hyperpigmentation after treatments (2,3). Patients on oral TNA experienced better results with IPL than patients with only IPL treatment (reduction of modified MASI score: 30.1% ± 21.1% vs.…”

Section: Discussionmentioning

confidence: 97%

“…No single treatment has been proven to be the most effective (2). Therefore, combination treatment using several possible modalities has been preferred and topical bleaching or whitening agents and/or chemical peelings along with laser-or light-based treatments have been generally adopted (3,4,5).…”

Section: Introductionmentioning

confidence: 99%

Role of oral tranexamic acid in melasma patients treated with IPL and low fluence QS Nd:YAG laser

Cho

Choi

Cho

et al. 2011

Journal of Dermatological Treatment

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“…Thus logically a TC cream would have superior results to the chemical peel! This is highlighted by the studies where TC have been combined and compared with lasers and have been found to have superior results,[101112] which probably puts a question mark on the unnecessary use of lasers in melasma.…”

mentioning

confidence: 99%

“…The use of lasers for the treatment of melasma cannot be recommended as a first line treatment of melasma due to their unpredictable efficacy and safety. [101112131415161718192021222324] They can be considered as third line treatment when all other modalities have failed and patient wishes to try alternative treatment. Such treatments are not curative and should be made clear to patients when such treatments are offered to the patient.…”

mentioning

confidence: 99%