Sequential extraction, characterization and antioxidant activity of polysaccharides from Fritillaria pallidiflora Schrenk

Rozi, Parhat; Abuduwaili, Aytursun; Mutailifu, Paiheerding; Gao, Yanhua; Rakhmanberdieva, R. K.; Aisa, Haji Akber; Yili, Abulimiti

doi:10.1016/j.ijbiomac.2019.03.029

Cited by 120 publications

(45 citation statements)

References 41 publications

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“…There is no uniform standard for the surface structure of polysaccharides, including spherical, flake, and branched, which are related to the different sources and extraction methods of polysaccharides (Zhao, 2020). Studies have shown that the general structure of polysaccharides at 500 to 1,000 magnification is honeycomb, rough surface, and porous structure, indicating that the intermolecular attraction is weak, and the main shape of polysaccharides is spherical or flake (Rozi et al., 2019). Generally, phosphorylation and acetylation are irregular sheet fiber structures.…”

Section: Structural Characterization Of Plant Polysaccharidesmentioning

confidence: 99%

Extraction, separation, modification, structural characterization, and antioxidant activity of plant polysaccharides

Huang

2020

Chem Biol Drug Des

117

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Polysaccharide is an important macromolecule with biological activity, and its biological activity is closely related to its structure. The extraction methods and modification methods of polysaccharides directly affect the structure of polysaccharides and then affect the biological activities of polysaccharides. In this paper, the extraction, separation, and modification of polysaccharides and their advantages and disadvantages were reviewed, and the research methods of structure characterization and antioxidant activity were discussed. This not only provides ideas for optimizing the extraction, separation, and modification methods of plant polysaccharides, but also provides the basic theoretical basis for the structural analysis and antioxidant activity research of plant polysaccharides.

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Section: Structural Characterization Of Plant Polysaccharidesmentioning

confidence: 99%

Extraction, separation, modification, structural characterization, and antioxidant activity of plant polysaccharides

Huang

2020

Chem Biol Drug Des

117

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“…As shown in Figure , the characteristic absorption peak of GYT‐1, GYT‐2, and GYT‐3 in infrared spectra of about 3100–3500 cm −1 , 1870–1650 cm −1 , and 1400–1200 cm −1 was corresponding to the stretching vibration of O‐H, C=O and the angular vibration of C‐H, respectively (Jahanbin, Abbasian, & Ahang, ; Xu et al, ; Yu et al, ). The signal of 1200–1000 cm −1 was assigned to the stretching vibration of C‐O‐C, indicating the presence of pyranose ring (Rozi et al, ). Infrared spectra proved that there were characteristic absorption peaks of polysaccharides in three fractions.…”

Section: Resultsmentioning

confidence: 99%

“…The signal of 1200-1000 cm −1 was assigned to the stretching vibration of C-O-C, indicating the presence of pyranose ring (Rozi et al, 2019). Infrared spectra proved that there were characteristic absorption peaks of polysaccharides in three fractions.…”

Section: Infrared Spectrum Analysismentioning

confidence: 93%

Extraction, purification, characterization, anticoagulant activity, and anticoagulant mechanism of polysaccharides from the heads of Hypomesus olidus

Zhang

et al. 2019

Food Science & Nutrition

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The aim of this work was to extract, isolate, and purify polysaccharides from the heads of Hypomesus olidus and to evaluate their anticoagulant activities and anticoagulant mechanisms. Response surface methodology was used to optimize the extraction conditions for ultrasonic‐assisted extraction of polysaccharides from the heads of Hypomesus olidus. The optimal extraction conditions consisted of ultrasonic power of 275 W, ultrasonic time of 50 min, and solid–liquid ratio of 5 ml/g, giving the yield of crude polysaccharides (GYT) of 7.73 ± 0.042%. Three polysaccharide fractions, GYT‐1, GYT‐2, and GYT‐3 were purified from GYT by using DEAE‐cellulose‐52 column and Sephadex G‐100 column for anticoagulant activities. The results showed that two doses (2 and 4 mg/ml) of GYT‐1 and GYT‐3 could significantly prolong (p < .01) in partial thromboplastin time (APTT) (2.19 and 2.37 times, 2.22 and 2.44 times, respectively) and thrombin time (TT) (2.39 and 2.46 times, 2.44 and 2.80 times, respectively) compared with normal control. In particular, GYT‐3 had stronger anticoagulant activity than GYT‐1, and it was composed of arabinose, fructose, glucose, and lactose with molar ratios of 0.595:1: 2.026:0.273. However, GYT‐2 had no anticoagulant activity (p > .05). In addition, anticoagulation mechanism of polysaccharides from the heads of Hypomesus olidus (GYT‐3) was evaluated. The results showed that the anticoagulant activity of GYT‐3 was based on their binding with antithrombin AT‐III. And the inhibitory effects of GYT‐3 on factor IIa and Xa were related to the concentration of AT‐III in plasma. This study may provide a new and promising anticoagulant drug.

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“…Three isosteroidal alkaloids (peimisine, peimine, and peiminine) that are abundantly found in Fritillaria bulbs exist as acidic water-soluble heteropolysaccharides (average molecular weight: ~ 7.44 kDa) in F. unibracteata var . wabuensis ; the acidic fraction FPSP-H2-1 from F. pallidiflora process a strong antioxidant effect against 1,1-diphenyl-2-picrylhydrazyl and 2,2ʹ-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) free radicals [ 73 , 121 , 122 ]. The comparison analysis of six isosteroidal alkaloids ( 2 , 11 , 13 , 22 , 44 , and 88 ) with different chemical structures from F. cirrhosa supported the results, showing that five components ( 2 , 13 , 22 , 44 , and 88 ) exhibited more potent effect against cigarette smoke extract-induced oxidative stress than imperialine 11 by activating the Nrf2-mediated antioxidant pathway [ 123 ].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Natural drug sources for respiratory diseases from Fritillaria: chemical and biological analyses

et al. 2021

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Fritillaria naturally grows in the temperate region of Northern Hemisphere and mainly distributes in Central Asia, Mediterranean region, and North America. The dried bulbs from a dozen species of this genus have been usually used as herbal medicine, named Beimu in China. Beimu had rich sources of phytochemicals and have extensively applied to respiratory diseases including coronavirus disease (COVID-19). Fritillaria species have alkaloids that act as the main active components that contribute multiple biological activities, including anti-tussive, expectorant, and anti-asthmatic effects, especially against certain respiratory diseases. Other compounds (terpenoids, steroidal saponins, and phenylpropanoids) have also been identified in species of Fritillaria. In this review, readers will discover a brief summary of traditional uses and a comprehensive description of the chemical profiles, biological properties, and analytical techniques used for quality control. In general, the detailed summary reveals 293 specialized metabolites that have been isolated and analyzed in Fritillaria species. This review may provide a scientific basis for the chemical ecology and metabolomics in which compound identification of certain species remains a limiting step.

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Sequential extraction, characterization and antioxidant activity of polysaccharides from Fritillaria pallidiflora Schrenk

Cited by 120 publications

References 41 publications

Extraction, separation, modification, structural characterization, and antioxidant activity of plant polysaccharides

Extraction, separation, modification, structural characterization, and antioxidant activity of plant polysaccharides

Extraction, purification, characterization, anticoagulant activity, and anticoagulant mechanism of polysaccharides from the heads of Hypomesus olidus

Natural drug sources for respiratory diseases from Fritillaria: chemical and biological analyses

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