Sequential Changes of the Five Immunoglobulin Classes and Other Responses in Infectious Mononucleosis

Bahna, Sami L.; Heiner, Douglas C.; Horwitz, Charles A.

doi:10.1159/000233507

Cited by 15 publications

(4 citation statements)

References 25 publications

(35 reference statements)

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“…During IM, activation of B lineage cells by EBV results in polyclonal immunoglobulin production and increased serum concentrations of immunoglobulin subclasses [ 12 , 13 ]. We found that IM patients from both cohorts showed higher total serum IgM and IgG levels as compared to controls ( Figure 3 A).…”

Section: Resultsmentioning

confidence: 99%

Infectious Mononucleosis Triggers Generation of IgG Auto-Antibodies against Native Myelin Oligodendrocyte Glycoprotein

Kakalacheva

Regenass

Wiesmayr

et al. 2016

Viruses

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A history of infectious mononucleosis (IM), symptomatic primary infection with the Epstein Barr virus, is associated with the development of autoimmune diseases and increases the risk to develop multiple sclerosis. Here, we hypothesized that immune activation during IM triggers autoreactive immune responses. Antibody responses towards cellular antigens using a HEp-2 based indirect immunofluorescence assay and native myelin oligodendrocyte glycoprotein (MOG) using a flow cytometry-based assay were determined in 35 patients with IM and in 23 control subjects. We detected frequent immunoglobulin M (IgM) reactivity to vimentin, a major constituent of the intermediate filament family of proteins, in IM patients (27/35; 77%) but rarely in control subjects (2/23; 9%). IgG autoantibodies binding to HEp-2 cells were absent in both groups. In contrast, IgG responses to native MOG, present in up to 40% of children with inflammatory demyelinating diseases of the central nervous system (CNS), were detectable in 7/35 (20%) patients with IM but not in control subjects. Normalization of anti-vimentin IgM levels to increased total IgM concentrations during IM resulted in loss of significant differences for anti-vimentin IgM titers. Anti-MOG specific IgG responses were still detectable in a subset of three out of 35 patients with IM (9%), even after normalization to increased total IgG levels. Vimentin-specific IgM and MOG-specific IgG responses decreased following clinical resolution of acute IM symptoms. We conclude from our data that MOG-specific memory B cells are activated in subset of patients with IM.

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Section: Resultsmentioning

confidence: 99%

Infectious Mononucleosis Triggers Generation of IgG Auto-Antibodies against Native Myelin Oligodendrocyte Glycoprotein

Kakalacheva

Regenass

Wiesmayr

et al. 2016

Viruses

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“…The findings that total IgE serum antibodies are elevated in patients with primary and secondary dengue virus infections compared to nondengue patients indicates that dengue virus infections exert a strong stimulatory effect on IgE synthesis. The non-dengue group of patients included patients with acute Epstein Barr virus and cytomegalovirus infections, which also cause elevation of the levels of total IgE in the serum [Bahna et al, 1984;van Loon et al, 1987], resulting in a non-significant difference between the non-dengue patients and patients with a primary dengue virus infection. Increased levels of total IgE serum antibodies in the acute phase of disease of both primary and secondary infections may indicate that dengue virus infections also stimulate a non-antigen-specific activation pathway for IgE production.…”

Section: Discussionmentioning

confidence: 99%

Elevated levels of total and dengue virus‐specific immunoglobulin E in patients with varying disease severity

Koraka

Murgue

Deparis

et al. 2003

Journal of Medical Virology

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The kinetics of total and dengue virus-specific immunoglobulin E (IgE) were studied in serial serum samples obtained from 168 patients, 41 of whom suffered from primary dengue virus infection and 127 suffered from secondary dengue virus infection. Seventy-one patients were classified as dengue fever, 30 as dengue hemorrhagic fever, and 67 as dengue shock syndrome. A control group included single serum samples from patients with a herpes virus infection (n = 14), non-dengue febrile patients (n = 10), and healthy blood donors (n = 10). Patients with dengue virus infection had higher levels of total and dengue virus-specific IgE than non-dengue patients (P < 0.05). Patients with secondary dengue virus infections had not significantly increased levels of both total and dengue virus-specific IgE in the acute phase of disease compared to patients with primary dengue virus infections. Dengue virus-specific IgE was significantly higher in dengue hemorrhagic fever and/or dengue shock syndrome patients compared to dengue fever and non-dengue patients (P < 0.05). In conclusion, this study showed elevated total and dengue virus-specific IgE serum antibody levels in the acute stage of disease. Therefore, measurement of both total and dengue virus-specific IgE serum antibodies can be used as an additional prognostic marker in the development of severe complications in dengue virus infections. In addition, the presence and increase of dengue virus-specific IgE serum antibodies in patients with dengue virus infections is suggestive of the pathogenetic role that IgE may play in the hemostatic disorders observed in dengue hemorrhagic fever and dengue shock syndrome.

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“…In three individuals with low-level anti-HBc in our study, the anti-HBc IgM and anti-HBc IgAl response was secondary to an acute or reactivated Epstein-Barr virus infection. IgA has been shown to be the next most responsible immunoglobulin after IgM for the elevation of total immunoglobulin levels in infectious mononucleosis caused by Epstein-Barr virus (2).…”

Section: Discussionmentioning

confidence: 99%

Enzyme immunoassay for anti-hepatitis B core (HBc) immunoglobulin G1 and significance of low-level results in competitive assays for anti-HBc

Sällberg

Magnius

1989

J Clin Microbiol

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An enzyme immunoassay (EIA) for anti-hepatitis B core (HBc) immunoglobulin Gi (IgGl) was compared with a commercial radioimmunoassay (RIA) for anti-HBc antibody (Corab; Abbott Laboratories, North Chicago, 111.). In parallel tests of 445 consecutive samples, discrepant results were obtained with 2 samples, 1 of which was positive only by the RIA and the other of which was positive only by the EIA for anti-HBc IgG1. In tests of another 192 samples with low blocking activity in the RIA (inhibition range, 90 to 30%), 10 samples gave discrepant results, 5 of which were positive only by the RIA and the other 5 of which were positive only by the EIA for anti-HBc IgGl. Of 12 samples with discrepant results, 11 samples were tested further for anti-HBc IgG3, IgM, and IgAl by the EIA. Of these, seven samples were positive for anti-HBc IgGl, anti-HBc IgG3, or both. All seven samples were also positive for anti-hepatitis B surface (HBs) antigen. Three samples were negative for anti-HBc IgGl, anti-HBc IgG3, or both but were positive for anti-HBc IgM, anti-HBc IgAl, or both; and one sample was reactive only in the RIA. These four samples were all negative for anti-HBs. Thus, low-level results in the RIA caused by anti-HBc IgM, anti-HBc IgA, or both reflect the unspecific activation of immature B lymphocytes that is not related to previous exposure to hepatitis B virus (HBV). In contrast, the presence of anti-HBc IgGl, anti-HBc IgG3, or both indicates differentiated anti-HBc IgG-producing plasma cells and previous exposure to HBV, as was also shown by the presence of anti-HBs. On class and subclass determination for confirmation of positivity for anti-HBc in 19 serum samples, which was identified by screening of blood from 1,343 donors by a competitive EIA (Hepanostika; Organon), 9 samples with positive results, all low level, did not indicate previous exposure to HBV. It was concluded that determination of classes and subclasses of anti-HBc provides a tool for discriminating positive anti-HBc results not caused by HBV exposure.

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Sequential Changes of the Five Immunoglobulin Classes and Other Responses in Infectious Mononucleosis

Cited by 15 publications

References 25 publications

Infectious Mononucleosis Triggers Generation of IgG Auto-Antibodies against Native Myelin Oligodendrocyte Glycoprotein

Infectious Mononucleosis Triggers Generation of IgG Auto-Antibodies against Native Myelin Oligodendrocyte Glycoprotein

Elevated levels of total and dengue virus‐specific immunoglobulin E in patients with varying disease severity

Enzyme immunoassay for anti-hepatitis B core (HBc) immunoglobulin G1 and significance of low-level results in competitive assays for anti-HBc

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