Elevated levels of total and dengue virus‐specific immunoglobulin E in patients with varying disease severity

Koraka, Penelope; Murgue, Bernadette; Deparis, Xavier; Setiati, Tatty E.; Suharti, Catharina; Gorp, Eric C. M. Van; Hack, C. E.; Osterhaus, Albert D. M. E.; Groen, Jan

doi:10.1002/jmv.10358

Cited by 72 publications

(58 citation statements)

References 25 publications

(23 reference statements)

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“…Additionally, levels of vascular endothelial growth factor were significantly elevated in patients with DHF compared with those in DF patients or control patients (185). Levels of soluble vascular cell adhesion molecule 1, evidence of endothelial cell activation, were found to be significantly elevated in DSS patients compared to those in DF patients, and levels among DSS patients were higher than in DHF patients, although the latter did not reach statistical significance (104). Finally, levels of plasminogen activator inhibitor type 1 at admission were associated with a fatal outcome (124).…”

Section: Prognostic Indicators Of Severe Dengue Infectionmentioning

confidence: 84%

Recent Advances in Deciphering Viral and Host Determinants of Dengue Virus Replication and Pathogenesis

Clyde

Kyle

Harris

2006

J Virol

328

301

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2Dengue virus (DENV) is a member of the Flavivirus genus of the Flaviviridae family of enveloped, positive-strand RNA viruses. The Flavivirus genus includes viruses transmitted by mosquitoes and ticks, as well as zoonotic agents with no known arthropod vector. In addition to DENV, flaviviruses that are significant threats to human health include yellow fever virus, West Nile virus (WNV), Japanese encephalitis virus, and tickborne encephalitis virus. The dengue viruses are comprised of four distinct serotypes, DENV1 through DENV4, which are transmitted to humans through the bites of two mosquito species: Aedes aegypti and A. albopictus.DENV causes a wide range of diseases in humans, from the acute febrile illness dengue fever (DF) to life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). DF is a self-limited though debilitating illness characterized by fever, headache, retro-orbital pain, myalgia, arthralgia, and rash. DHF is marked by increased vascular permeability ("plasma leakage"), thrombocytopenia, and hemorrhagic manifestations; DSS occurs when fluid leakage into the interstitial spaces results in shock, which without appropriate treatment may lead to death. Dengue has spread throughout tropical and subtropical regions worldwide over the past several decades, with an estimated 100 million infections and tens of millions of cases occurring annually. DHF/DSS is one of the leading causes of pediatric hospitalization in Southeast Asia, where the syndrome first emerged 50 years ago, and has become endemic to many Latin American countries over the last 25 years (reviewed in references 64 and 184). DENGUE VIRUS REPLICATIONThe intracellular life cycles of the flaviviruses are very similar (Fig. 1). Infection with one of the arthropod-borne flaviviruses begins when the vector takes a blood meal and the virus is introduced into the host. The virus binds to and enters a permissive host cell via receptor-mediated endocytosis. Upon internalization and acidification of the endosome, fusion of viral and vesicular membranes allows entry of the nucleocapsid into the cytoplasm and genome uncoating. Translation of the input strand takes place; then the virus switches from translation to synthesis of a negative-strand intermediate, which serves as a template for the production of multiple copies of positive-strand viral RNA (vRNA). Successive rounds of translation produce high levels of viral proteins; the structural protein capsid or core (C), premembrane (prM), and envelope (E) proteins, along with vRNA, are assembled into progeny virions, which are transported through the Golgi compartment and secreted (reviewed in reference 56). While much that is assumed about DENV has been characterized for related flaviviruses such as yellow fever virus, WNV, Japanese encephalitis virus, and tick-borne encephalitis virus, for the purposes of this review we will focus on recent research that has concentrated specifically on the four serotypes of DENV. CELLULAR TROPISM, BINDING, AND ENTRYThe replication cycle of DENV ...

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Section: Prognostic Indicators Of Severe Dengue Infectionmentioning

confidence: 84%

Recent Advances in Deciphering Viral and Host Determinants of Dengue Virus Replication and Pathogenesis

Clyde

Kyle

Harris

2006

J Virol

328

301

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“…There have been several studies on this aspect, but most of them have included children. Koraka et al determined the isotype profile in dengue-virus-infected children in Indonesia [15,16]. They reported increased levels of IgA, IgG1, IgG4 and IgE in DHF and DSS cases.…”

Section: Introductionmentioning

confidence: 96%

Higher levels of dengue-virus-specific IgG and IgA during pre-defervescence associated with primary dengue hemorrhagic fever

et al. 2015

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Dengue hemorrhagic fever (DHF), although predominantly associated with secondary infections, has also been reported in primary infections. An enhanced immune response including antibodies and cytokines is implicated in the pathogenesis of secondary DHF. However, the factors operating in primary DHF are poorly understood. To understand the role of the antibody response, the relative levels of different antibody isotypes during the acute phase of infection in primary and secondary dengue infections were determined. Levels of DENV-specific IgM, IgG, IgA and IgE were measured in the serum samples of 200 dengue patients and 20 dengue-naïve individuals. Samples were collected within 15 days of onset of illness. The DENV-specific IgM levels were significantly higher in DF cases compared to DHF, which was more evident in secondary infections and in post-defervescence samples. The levels of IgG, IgA and IgE were higher in DHF cases, with greater significance in primary infections. A higher level of IgG in DHF cases was evident in pre-defervescence samples, whilst the IgE level was higher in pre- and post-defervescence samples. There was a significant correlation of IgG titres with platelet counts, with higher titres associated with lower platelet counts. It is speculated that IgG, IgA and IgE produced in response to primary infections may contribute to pathogenesis, whilst IgM produced in response to secondary infections may protect against progression to severe disease.

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“…Some authors have described IgE antibodies elevation in patients with dengue infections. [46] found both total and specific increased of IgE levels in patients with DHF, [47] observed higher levels of total IgE in dengue patients contrary to control group (subjects with no exposure); [48] observed higher levels of specific IgE in DHF/DSS cases than DF cases and healthy individuals; [13] found significant differences of IgE OD ratios between primary and secondary dengue cases, observing the higher values for the last group. Similar to IgA response, IgE OD ratios were detectable in secondary D and SD infection while in primary was absent.…”

Section: Discussionmentioning

confidence: 99%

Virological and Serological Markers in Dengue Patients from Venezuela and Nicaragua

Ruiz¹,

Vázquez²,

Villegas³

et al. 2017

OALib

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Latest estimates suggest 390 million infections of dengue occur each year, of which 100 million results in symptomatic disease. The new clinical classification proposed by WHO-TRD 2009 simplifies dengue fever (DF) into dengue (D) and severe dengue (SD) with an intermediary group of "dengue with warning signs" (DWS). Early, sensitive and specific diagnosis of dengue is needed for appropriate patient management as well as for early epidemic detection. Virological and serological markers in sera from dengue confirmed patients from Venezuela and Nicaragua were evaluated. A total of 232 sera collected in the acute (days 1 to 5 of fever onset) and convalescent (days 7 to 14) phases of illness were tested by Platelia NS1 antigen ELISA and IgM, IgA and IgE capture ELISA methods. NS1 was detected with highest OD values in the acute phase for primary and secondary cases. IgM was detected in primary and secondary groups but the highest OD figures were observed after defervescence day. IgA and IgE detection were almost absent for primary cases, contrary to secondary cases which showed higher values but after defervescence day. NS1 could be used as effective diagnostic marker in the acute phase of illness for primary and secondary dengue infections. IgM detection is still an invaluable tool for routine dengue diagnosis but delay. IgA detection could define secondary infection in early phase of illness. IgA/IgE could be evaluated as prognostic markers associated to SD cases.

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Elevated levels of total and dengue virus‐specific immunoglobulin E in patients with varying disease severity

Cited by 72 publications

References 25 publications

Recent Advances in Deciphering Viral and Host Determinants of Dengue Virus Replication and Pathogenesis

Recent Advances in Deciphering Viral and Host Determinants of Dengue Virus Replication and Pathogenesis

Higher levels of dengue-virus-specific IgG and IgA during pre-defervescence associated with primary dengue hemorrhagic fever

Virological and Serological Markers in Dengue Patients from Venezuela and Nicaragua

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